4 ms·

The 207 page Supplementary Material is here: https://static-content.springer.com/esm/art%3A10.1038%2Fs41588-018-0147-3/MediaObjects/41588_2018_147_MOESM1_ESM.pd

The 207 page Supplementary Material is here: https://static-content.springer.com/esm/art%3A10.1038%2Fs41588-018-0147-3/MediaObjects/41588_2018_147_MOESM1_ESM.pdf https://static-content.springer.com/esm/art%3A10.1038%2Fs415... (probably pay walled). Interesting discussion of genes and pathways involved around page 84. "Results: Causal Genes and Enriched Gene Sets" I'll just type in the pathways. ( Supplementary Figure 22.) "Brain Specific Expression of Significantly Enriched Gene Sets across Development. (page 196)": Chromatic modification, protein binding transcription factor activity, npBAF complex, Central nervous system neuron differentiation, forebrain development, partial posttnatal lethality, abnormal cerebral cortext morphology, endometrial cancer , GAB1 signalosome, regulation of nervous system development, telencephaol cell migration, protein tyrosine kinase activity , neuron recognition, axon guidance, small cerebellum protein phosphatase regulator activity, signaling by eGFR, dendrite morphogenesis, signaling by NGF, regulation of neuron projection development, behavioral fear response, DAG and IP signaling, associative learning , voltage-gate calcium channel activity , ataxia, extracellular-glutamte-gate ion channel activity, post NMDA receptor activation events, regulation of neurotransmitter levels, regulation of synaptic transmission, synapse part ,gate channel activity. Single Nucleotide Polymorphisms (snps) discussed in supplement are:rs10189857 rs1167898 rs11678980 rs18235539 rs182355396 rs186456786 rs186456786 rs186456786 rs5951458 rs61734410 Links to dbsnp for snps discussed in supplement: https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=10189857 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=101... https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=1167898 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=116... https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=11678980 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=116... https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=18235539 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=182... https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=182355396 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=182... https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=186456786 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=186... https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=5951458 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=595... https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=61734410 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=617... https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=62422687 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=624...

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Top 20 snps sorted by pval (top best) for Cognitive Performance ( from excel spreadsheet from https://www.nature.com/articles/s41588-018-0147-3#Sec34 https://www.nature.com/articles/s41588-018-0147-3#Sec34 ) dbSNP Frequency Allele 1 Effect size https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=2352974 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=235... rs2352974 0.4875 -0.0319 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=1906252 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=190... rs1906252 0.4873 0.0307 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=13107325 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=131... rs13107325 0.0750 -0.0543 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=9384679 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=938... rs9384679 0.3717 -0.0282 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=3128341 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=312... rs3128341 0.2052 -0.0334 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=2426132 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=242... rs2426132 0.4576 0.0270 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=12128707 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=121... rs12128707 0.7333 -0.0303 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=11793831 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=117... rs11793831 0.4158 0.0269 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=148696809 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=148... rs148696809 0.8828 -0.0406 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=2726513 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=272... rs2726513 0.4069 -0.0261 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=12448902 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=124... rs12448902 0.6061 0.0260 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=3740422 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=374... rs3740422 0.3506 -0.0255 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=8054299 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=805... rs8054299 0.6834 -0.0256 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=11123820 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=111... rs11123820 0.6057 -0.0243 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=10874938 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=108... rs10874938 0.5103 0.0236 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=10875914 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=108... rs10875914 0.5993 -0.0237 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=1892419 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=189... rs1892419 0.7699 0.0276 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=6550835 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=655... rs6550835 0.3249 -0.0248 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=11662271 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=116... rs11662271 0.4733 0.0232

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Top 20 snps sorted by pval (top best) for Cognitive Performance ( from excel spreadsheet from https://www.nature.com/articles/s41588-018-0147-3#Sec34 https://www.nature.com/articles/s41588-018-0147-3#Sec34 ) dbSNP Frequency Allele 1 Effect size https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=2352974 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=235... rs2352974 0.4875 -0.0319 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=1906252 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=190... rs1906252 0.4873 0.0307 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=13107325 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=131... rs13107325 0.0750 -0.0543 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=9384679 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=938... rs9384679 0.3717 -0.0282 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=3128341 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=312... rs3128341 0.2052 -0.0334 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=2426132 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=242... rs2426132 0.4576 0.0270 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=12128707 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=121... rs12128707 0.7333 -0.0303 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=11793831 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=117... rs11793831 0.4158 0.0269 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=148696809 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=148... rs148696809 0.8828 -0.0406 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=2726513 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=272... rs2726513 0.4069 -0.0261 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=12448902 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=124... rs12448902 0.6061 0.0260 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=3740422 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=374... rs3740422 0.3506 -0.0255 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=8054299 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=805... rs8054299 0.6834 -0.0256 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=11123820 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=111... rs11123820 0.6057 -0.0243 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=10874938 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=108... rs10874938 0.5103 0.0236 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=10875914 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=108... rs10875914 0.5993 -0.0237 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=1892419 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=189... rs1892419 0.7699 0.0276 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=6550835 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=655... rs6550835 0.3249 -0.0248 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=11662271 https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=116... rs11662271 0.4733 0.0232