9 ms·

Thinning in brain regions important for memory linked to sedentary habits

152 points by neverminder 9y ago

banachtarski 9y ago
Nothing about what people were actually doing while they were sitting? Watching TV? Staring into space? I don't know how to take something like this seriously (after reading this article in its entirety, not the linked paper)
- comboy 9y ago
  Seems like a critical piece of information. You could say that people who take frequent brakes from their work to go outdoor and stand there for a while are likely to die younger. That's smokers behavior. If it was random sample from general population then I'm betting on watching TV. Studies seem to suggest that if you are doing a lot of cognitive work it is good for your brain and memory. Apart from the somewhat new trend of standing desks, most jobs that are about thinking are done in a sitting position.
hownottowrite 9y ago
“UCLA researchers recruited 35 people ages 45 to 75 and asked about their physical activity levels and the average number of hours per day they spent sitting over the previous week.“
- rambojazz 9y ago
  Isn't UCLA among the top universities in the world? How can they publish a research like this (asking a few questions to 35 people) and draw such formidable conclusions? The title sounds like they've discovered something new that applies to all humans...
  - true_religion 9y ago
    That's actually how statistics works. You don't need 100,000+ people to make a readily generalizable conclusion. If the differences are significant, they'll appear with as few as 35 people, carefully selected, and give you a confidence level of X that it applies to a population size of Y. Whilst I don't know the details of this particular study, I do recall doing homework problems about correlation confidence. In layman's terms, maybe this example will help: Imagine a study where they found that 100% of people who were "sitting" had bent knees. Essentially no one could bring their hips and ankles closer together without bending their knees. With such a significant correlation, you could generalize from a population of 10 to one of trillions so long as the ten was randomly chosen, and there were no other correlative factors.
    - pbhjpbhj 9y ago
      Aside from things like false legs and injury bringing your hips and ankles together like that is a physical impossibility; that doesn't provide a good analogue. People sit with straight legs too, but if you test by asking people to sit on a chair it will show everyone sits with bent knees, where in fact lots of people sit on the floor, beach, or bed (say) with straight legs. FWIW I sit on a chair with straight legs, on top of my computer tower. If you take a sample of 35 people in China you can with a reasonable confidence level say all people are Chinese, or perhaps a very small proportion aren't, depends how lucky you get. It's wrong of course, despite Chinese being the majority (17% according to Wikipedia). It's fine as a preliminary, but it doesn't show anything useful yet other than the need to perform further study IMO. A report on this should say something like "viability study suggests sitting and brain changes are related but doesn't provide enough confidence as yet". Which it sorta does, from this section on: >"This study does not prove that too much sitting causes thinner brain structures, but instead that more hours spent sitting are associated with thinner regions, researchers said." But either ScienceDaily or UCLA have not lead with that information, matching the current style.
  - TangoTrotFox 9y ago
    It becomes quite evident in studies like this, but nearly all social science related studies are based on the exact same pattern. For instance the emotional intelligence study, which has been repeatedly cited and been reasonably influential, was based on putting people into groups, having them do tasks such as [literally] writing a shopping list, and then showing that the groups that did the tasks most efficiently were not strictly composed of those that had the highest IQ. So therefore it was implied that individual merit alone does not determine results of groups, but rather some 'emotional intelligence' does. It's absolutely atrocious logic since B is in no way implied from A. For instance to show this then you would need to, at the minimum, put the people that all individually do the best at e.g. writing a shopping list, into a group, and then compare them against people that individually do worse but score well on the [again literally] 'Reading the Eyes in the Mind' test that was used to measure 'emotional intelligence'. Of course that was not done, and I don't think it's unreasonable to speculate because we know what the result would be - and that's not publishable. Yet bad science paired with an astounding headline and you are suddenly good to go. Yeah, a bit of a rant but it's incredibly disappointing how awful the social sciences have become. And that decline pairs ironically with a massive increase in the reporting of their results, which become ever more grand and increasingly clickbaity, in the media.
    - oldmancoyote 9y ago
      Are you equating IQ with merit? If so, you need to broaden your perspective.
      - TangoTrotFox 9y ago
        My opinion is not relevant one way or the other. I am describing the study.
  - nontechdude1 9y ago
    Sampling is studied as a way to save time without running a census for every experiment. Many universities use this technique. An intro to stats course could probably be found on Coursera that will go into this.
- tmalsburg2 9y ago
  In other words, tiny sample, results likely don't generalize, may also be false positive.
- chiefalchemist 9y ago
  Self-reported data? That isn't verified? That's nearly always a red flag. How about using a set of long haul truckers? In a before vs after sort of why? Their hours behind the wheel is documented (or should be). I would presume they're sitting behind the wheel :)
theprotocol 9y ago
Perhaps people who are either predisposed toward unhealthy outcomes, or are currently experiencing them (whether they realize it or not) are more sedentary. Correlation does not establish causation.
- callesgg 9y ago
  Um yes, the title should be more like: "Sitting correlates to Thinning in certain brain regions"
  - nonbel 9y ago
    Is it bad to have a "thin" brain and good to have a "fat" brain now? Can't this brain region become too large? What if the area is enlarged due to inflammation/swelling and these people with "thinning" are those without that problem? If the brain is too large it is considered a problem: https://en.wikipedia.org/wiki/Megalencephaly https://en.wikipedia.org/wiki/Megalencephaly This guy apparently has the second largest brain ever measured, and he was a serial killer: https://en.wikipedia.org/wiki/Edward_H._Rulloff https://en.wikipedia.org/wiki/Edward_H._Rulloff
    - MikkoFinell 9y ago
      The study was regarding density, not size.
      - nonbel 9y ago
        Where are you seeing that? Also, fine density/volume/mass, does it really change the argument? There is some optimal size for this region when it comes to certain functions, probably relative to the size of other regions. That size is probably suboptimal when it comes to other functions and there are tradeoffs going on. The press release seems to be assuming that thinner is bad automatically.
        MikkoFinell 9y ago
huffmsa 9y ago
Not even 3 months ago it was "standing desk users less focused, less productive". Which might be more about the kind of person a standing desk user is than it's effect.
- Bakary 9y ago
  My anecdotal experience tells me that those who adopt many efficiency boosting methods (standing desks, optimized keyboard layouts, various lifehacks, extreme customization of their work environment…) tend to be less inclined to focus on the actual work.
dombesz 9y ago
I wonder if this is true for physical inactivity in general? I suspect that using a standing desk instead of sitting down wouldn’t change the situation.
jaimex2 9y ago
Anti clickbait tldr: Too much sitting is ASSOCIATED with thinning brain structures.
scotchmi_st 9y ago
> This study does not prove that too much sitting causes thinner brain structures, but instead that more hours spent sitting are associated with thinner regions, researchers said. This is a bit of a non-story. The article doesn't go into what measures were taken to eliminate confounding factors, and it seems from the way it's worded that not many were taken. Maybe people who have a more sedentary lifestyle also tend to come from a lower social background, thus are more prone to physical and mental diseases. Or maybe people who sit more tend to be more obese, and it's really obesity that's associated here. It doesn't take a genius to think up more possible confounding variables. Also, a cohort of 35 people is tiny.
- ekianjo 9y ago
  > This is a bit of a non-story. You just summed up Science-daily. Every single day there's a revolution in sciences or understanding if you believe their articles.
- brownbat 9y ago
  > Maybe people who have a more sedentary lifestyle also tend to come from a lower social background My favorite confound is when Pauling convinced many reasonably educated higher SES people that vitamins were a miracle cure-all. Suddenly multivitamins did correlate with higher health outcomes! (Until later studies untangled this and found little broad effect, aside from specific vitamins during pregnancy or specific deficiencies.) Sort of a pop science self fulfilling prophecy. Or when we do things we think are smart, sometimes we pollute the evidence.
  - 0n34n7 9y ago
    Pop Science. Nice...
- fthssht 9y ago
  If this were the first of its kind yes, but given that there are numerous studies suggesting that exercise is good for the brain its reasonable hypothesis. Rather than a non-story I'd say it adds to a body of evidence for a strong hypothesis.
agumonkey 9y ago
what about the dual? moving, either walking, driving or longer always stimulates my brain. To the point that not moving I find myself very silent and believed I had a problem.
z28w 9y ago
Conclusion drawn from experiment on 35 samples? Must be kidding...
- always_good 9y ago
  Taking issue with small sample sizes is a popular way for the layperson to chime in with criticism, but it is rather empty and uneducated criticism. In statistics, sample size does not tell you if correlations are significant or not. Which is why it's amusing when someone thinks they are being a statistics pedant by pointing out a small sample size.
  - projektir 9y ago
    I think this is worth challenging. A small sample means there's a higher likelihood that the sample is not very random. It's often pulled from some easily available source, like a group of college students. An idealized perfect random small sample might be just fine for statistics, but there's little reason to believe that's the sample we're getting. Small samples should be a cause for suspicion.
ourmandave 9y ago
A "sitting is killing you" article based on a study of 35 people. Is this going to launch another wave of conflicting articles published every-other-week saying how to minimize it? "Eat fish 5 times a day while standing!" "New study: fish 10 times while doing squats!" "Latest: the fish does nothing! You need a 'weightless desk' in low earth orbit."
- amarant 9y ago
  Man that last idea sounds sweet! I'm up for that whether it prolongs my life or not!
kartan 9y ago
"The researchers next hope to follow a group of people for a longer duration to determine if sitting causes the thinning and what role gender, race, and weight might play in brain health related to sitting." This is just a preliminary study. It´s too soon to get any conclusions. But, it´s a good starting point for a hypothesis. I will like to see the results of the final study, even that is going to take a long time. I have seen many times links between sedentary life and illness. But this one looks promising as tries to find a mechanism on why this happens at the brain level that may affect cognition. And yes, before doing a more expensive study, they asked 35 people for a preliminary study. You don´t spend a lot of money to try to prove something without first trying to disprove it on the cheap. Translation for developers: before spending a lot of time to test something you first do a smoke test. If it passes you invest the time to test it fully. Otherwise, you go back to writing code.
netman21 9y ago
In my early career I was a car seat engineer which gave me a life long interest in seats. If you look at historical chairs it is amazing how recently the comfortable chair was introduced. I peg it at around 1920, about 30 years after the Morris chair, which was the beginning. Think of the colonial era Windsor chairs. You can imagine great thinkers sitting in them pulled up to their desks creating and thinking. But no way could you sit for the 10-12 hours a day most HN readers do. Go back further to images of classic times. Sitting devices were definitely not capable of being used for extended periods. So yes, it is worth thinking about the impact of comfortable furniture on how much we sit. But later. I am getting up to get a cup of coffee.
- w_t_payne 9y ago
  What can we do to support healthy physical posture and movement whilst also maximising productivity when working with with electronic representations of textual and numeric data? There are some obvious avenues to explore -- but it is not clear if anything is going to be available to consumers in the near future.
  - jgoodhcg 9y ago
    I'm really hoping VR headsets can provide a workspace where people can lay down or stand. The keyboard replacement in those positions might be hard to figure out.
    - ianai 9y ago
      That’s one of the easier problems. I just bought a split wireless keyboard. It actually feels alright just laying it in my thighs to typ.
  - arca_vorago 9y ago
    There are quite a few things that can be done. 1. Get management in on the importance of ergonomics in modern work-life. Like needs to be a large portion of budget and discussed with the board important. 2. Culturally teach the importance of ergonomics in computing. Make it a part of prereq college basic IT courses. 3. Interface types will change this equation. VR, wireless-VR, AR, advances in motion capture, and in brain-computer interfaces will offer alternatives that will have to be adapted and evolved into (I'm rooting for a foss future myself, as it will be more agile in the evolutionary process which is ony one of many reasons foss software is superior to proprietary.) 4. Change the outlook on the desk space and it's function. I was in really good shape in the Marine Corps but I still found time to play pc games, which all know can suck hours away, so I designed a workout program for at the desk in my barracks room. I turned what was a sedentary area into an active area just by changing my approach. For example, during CS matches, the rule was every death is max set of dips (using chair arms) squats (by pushing chair back out of the way) pushups, curls, or pullups, etc. Then rotate every time. I've also used balance balls as chairs in order to force me to focus on my core and ab static strength. There are many examples and each person is different, but the desk doesn't have to be a lazy place. (If you are interested in this I would start with horse stances to work with leg strength first and get the bloodflow to the gluteus maximus which is what excessive sitting restricts.) Ultimately, I've been saying for a while that VR with room sensing seems really promising to me because I envision a future of VR workout sessions, which could be really fun by gamification and get people in shape! It wouldn't be that hard to ship a kettlebell with a motion tracker in it. I have a game project (planned GPLclient/CC?contentbysub model) with a long goal of getting into that territory, but had to narrow scope away from recently. I'm mostly waiting for VR on gnu/linux to get better, hoping the Vive Pro has made progress in that area.
FLUX-YOU 9y ago
I just want a study that tells me the intensity and frequency of exercise that counter-acts the sitting plague. By now, all sitting studies sound like they're stating the obvious.
- rtehfm 9y ago
  Apparently, there's no _true_ offset for extended hours of sitting[1]. There might be some science/studies behind smart watches urging you to stand for a couple of minutes every hour, however. [1] https://www.theatlantic.com/health/archive/2016/08/the-new-exercise-mantra/495908/ https://www.theatlantic.com/health/archive/2016/08/the-new-e...
  - wwayer 9y ago
    A lot of people make a living sitting in a chair all day. What are we all supposed to do instead? The implications of this are pretty far-reaching.
    - always_good 9y ago
      > What are we all supposed to do instead? Depends on how much you care and how able you are to compel yourself into action. Almost every one of us reading this is in a position to abbreviate our work with physical activity at the very least. I just wager that most of us are too addicted to comfort to actually do anything about it in the face of the evidence. For example, we already know that a sedentary lifestyle is bad yet most people don't exercise.
oblib 9y ago
I don't know if my brain has "thinned" but I do know that after sitting for years coding I started experiencing a pinched nerve in my back, and that ain't no fun. I thought I was having a stroke the first time it happened about six months ago. I realized it was a pinched nerve after looking into it but it took several months to figure out exactly what stretches I needed to do to relieve and prevent them.
- ianai 9y ago
  Where’d you track that info down?
  - SuoDuanDao 9y ago
    Not OP, but I actually went to a physiotherapist. Well worth the investment if they know what they're doing.
    - ianai 9y ago
      Very very true. They’ve helped me immensely in the past.
  - oblib 9y ago
    Sorry for the slow reply. I read up on the symptoms and since I didn't feel any "pain" it indicated it was a pinched nerve. I started doing some stretches lying on my back and sometimes that stopped the "zinging" immediately but not every time. When it did I could feel my spine in the middle of my back "pop". And if I laid flat on my back I could feel my spine had hump in it. I could also feel some tingling in my feet and legs before it would start zinging me out, so I got to know when they were coming. One day when I felt the tingling I stood up and raised my arms straight up and arched my back backwards as far as I could and slowly lowered my arms by bringing them down while pulling them behind me as far as I could in a half circle motion. All kinds of "popping" noises happened and the tingling went away instantly. Over the next few weeks I had just a few full on zingers and when I did that stretch they went away almost instantly. Since then I've made a point to do those stretches several times a day and I've not had a full blown zinger in over a month. It was bad though. Damn near paralyzing on my left side and I could barely walk when it was happening.
epmaybe 9y ago
Here is the actual paper, for your reference. I'm appalled that ScienceDaily did not link this in their article. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195549 http://journals.plos.org/plosone/article?id=10.1371/journal....
- epmaybe 9y ago
  Note that in the paper, they mentioned controlling for age. Also mentioned is that this data is preliminary, hence the low sample size.
- nonbel 9y ago
  Here is the activity survey: http://www.sdp.univ.fvg.it/sites/default/files/IPAQ_English_self-admin_long.pdf http://www.sdp.univ.fvg.it/sites/default/files/IPAQ_English_... The paper was confusing because they reported an average of 7 hours sitting each day and 1500 minutes per week of "physical activity" (3.5 hrs a day). So basically anything besides sitting and sleeping seems to be counted as physical activity. It does sound like almost anything is counted as physical activity: "on how many days did you do moderate activities like carrying light loads, washing windows, scrubbing floors and sweeping inside your home"
HankB99 9y ago
Yes. And television is bad for your eyes. https://www.youtube.com/watch?v=JXCpYgd338U https://www.youtube.com/watch?v=JXCpYgd338U
eruci 9y ago
That's why I'm laying down.
whb07 9y ago
Time and time again more evidence is propping up stating the benefits of exercise. I think Patio11 summed it up well, roughly stating that as we are all working with the same hardware(the body) then we should work to maintain it in top shape. If you maintain your body in a weak state, it would seem that your body would have to maximize its output with a lesser performing system. Imagine trying to perform well when you have a heart that’s got 1/4 the performance of a well maintained one. Imagine the downstream effects of all this!
EGreg 9y ago
This seems to contradict another article posted on HN I read recently, which says memories are lost due to brain cell growth after physical activity! https://www.vox.com/2014/5/8/5695500/why-cant-you-remember-being-a-baby-science-explains https://www.vox.com/2014/5/8/5695500/why-cant-you-remember-b... http://www.sciencemag.org/news/2014/05/how-brain-deletes-old-memories http://www.sciencemag.org/news/2014/05/how-brain-deletes-old... Which contradicts yet another article which says that growing new brain cells can improve memory: http://www.dailymail.co.uk/health/article-1244332/How-running-jog-memory-creating-new-brain-cells.html http://www.dailymail.co.uk/health/article-1244332/How-runnin... So which is it? I think we need scientists to take two contradicting studies and try to find out the root cause of a discrepancy, instead of making a third study. To do that, they need to record as much as they can, and a meta-study needs to look at the actual discrepancies that can account for a change. https://slate.com/health-and-science/2017/06/daryl-bem-proved-esp-is-real-showed-science-is-broken.html https://slate.com/health-and-science/2017/06/daryl-bem-prove...
- jaclaz 9y ago
  > I think we need scientists to take two contradicting studies and try to find out the root cause of a discrepancy, instead of making a third study. Yes, the shorter form being ;-) : I think we need scientists.
pessimizer 9y ago
Maybe people ages 45 through 75 are going through the period of life which we traditionally associate with both a lowering of physical activity and increasing difficulties in memory. Sure would be nice if they linked the study or seriously cared about critiquing it. The real question should be whether both are also strongly associated with grey hair, number of grandchildren, and taste in film.
pbhjpbhj 9y ago
Interesting they do manual segmenting, who's working on image recognition to automate measuring of the various areas - presumably then all past scans [with patient acceptance] could be fed in to a system and the brain regions could be measured and classified. The correlation graphs are awesome! http://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0195549.g002 http://journals.plos.org/plosone/article/figure?id=10.1371/j... Not sure you could get a better randomisation if you tried with just 35 points??!
nadohs 9y ago
Maybe people with thinning in brain region associate with memory overestimate the amount of time sitting because they can’t recall as accurately what they were doing in between sitting sessions...

152 points by neverminder 9y ago

Nothing about what people were actually doing while they were sitting? Watching TV? Staring into space? I don't know how to take something like this seriously (after reading this article in its entirety, not the linked paper)

comboy 9y ago
Seems like a critical piece of information. You could say that people who take frequent brakes from their work to go outdoor and stand there for a while are likely to die younger. That's smokers behavior. If it was random sample from general population then I'm betting on watching TV. Studies seem to suggest that if you are doing a lot of cognitive work it is good for your brain and memory. Apart from the somewhat new trend of standing desks, most jobs that are about thinking are done in a sitting position.

hownottowrite 9y ago

“UCLA researchers recruited 35 people ages 45 to 75 and asked about their physical activity levels and the average number of hours per day they spent sitting over the previous week.“

rambojazz 9y ago
Isn't UCLA among the top universities in the world? How can they publish a research like this (asking a few questions to 35 people) and draw such formidable conclusions? The title sounds like they've discovered something new that applies to all humans...
- true_religion 9y ago
  That's actually how statistics works. You don't need 100,000+ people to make a readily generalizable conclusion. If the differences are significant, they'll appear with as few as 35 people, carefully selected, and give you a confidence level of X that it applies to a population size of Y. Whilst I don't know the details of this particular study, I do recall doing homework problems about correlation confidence. In layman's terms, maybe this example will help: Imagine a study where they found that 100% of people who were "sitting" had bent knees. Essentially no one could bring their hips and ankles closer together without bending their knees. With such a significant correlation, you could generalize from a population of 10 to one of trillions so long as the ten was randomly chosen, and there were no other correlative factors.
  - pbhjpbhj 9y ago
    Aside from things like false legs and injury bringing your hips and ankles together like that is a physical impossibility; that doesn't provide a good analogue. People sit with straight legs too, but if you test by asking people to sit on a chair it will show everyone sits with bent knees, where in fact lots of people sit on the floor, beach, or bed (say) with straight legs. FWIW I sit on a chair with straight legs, on top of my computer tower. If you take a sample of 35 people in China you can with a reasonable confidence level say all people are Chinese, or perhaps a very small proportion aren't, depends how lucky you get. It's wrong of course, despite Chinese being the majority (17% according to Wikipedia). It's fine as a preliminary, but it doesn't show anything useful yet other than the need to perform further study IMO. A report on this should say something like "viability study suggests sitting and brain changes are related but doesn't provide enough confidence as yet". Which it sorta does, from this section on: >"This study does not prove that too much sitting causes thinner brain structures, but instead that more hours spent sitting are associated with thinner regions, researchers said." But either ScienceDaily or UCLA have not lead with that information, matching the current style.
- TangoTrotFox 9y ago
  It becomes quite evident in studies like this, but nearly all social science related studies are based on the exact same pattern. For instance the emotional intelligence study, which has been repeatedly cited and been reasonably influential, was based on putting people into groups, having them do tasks such as [literally] writing a shopping list, and then showing that the groups that did the tasks most efficiently were not strictly composed of those that had the highest IQ. So therefore it was implied that individual merit alone does not determine results of groups, but rather some 'emotional intelligence' does. It's absolutely atrocious logic since B is in no way implied from A. For instance to show this then you would need to, at the minimum, put the people that all individually do the best at e.g. writing a shopping list, into a group, and then compare them against people that individually do worse but score well on the [again literally] 'Reading the Eyes in the Mind' test that was used to measure 'emotional intelligence'. Of course that was not done, and I don't think it's unreasonable to speculate because we know what the result would be - and that's not publishable. Yet bad science paired with an astounding headline and you are suddenly good to go. Yeah, a bit of a rant but it's incredibly disappointing how awful the social sciences have become. And that decline pairs ironically with a massive increase in the reporting of their results, which become ever more grand and increasingly clickbaity, in the media.
  - oldmancoyote 9y ago
    Are you equating IQ with merit? If so, you need to broaden your perspective.
    - TangoTrotFox 9y ago
      My opinion is not relevant one way or the other. I am describing the study.
- nontechdude1 9y ago
  Sampling is studied as a way to save time without running a census for every experiment. Many universities use this technique. An intro to stats course could probably be found on Coursera that will go into this.
tmalsburg2 9y ago
In other words, tiny sample, results likely don't generalize, may also be false positive.
chiefalchemist 9y ago
Self-reported data? That isn't verified? That's nearly always a red flag. How about using a set of long haul truckers? In a before vs after sort of why? Their hours behind the wheel is documented (or should be). I would presume they're sitting behind the wheel :)

theprotocol 9y ago

Perhaps people who are either predisposed toward unhealthy outcomes, or are currently experiencing them (whether they realize it or not) are more sedentary. Correlation does not establish causation.

callesgg 9y ago
Um yes, the title should be more like: "Sitting correlates to Thinning in certain brain regions"
- nonbel 9y ago
  Is it bad to have a "thin" brain and good to have a "fat" brain now? Can't this brain region become too large? What if the area is enlarged due to inflammation/swelling and these people with "thinning" are those without that problem? If the brain is too large it is considered a problem: https://en.wikipedia.org/wiki/Megalencephaly https://en.wikipedia.org/wiki/Megalencephaly This guy apparently has the second largest brain ever measured, and he was a serial killer: https://en.wikipedia.org/wiki/Edward_H._Rulloff https://en.wikipedia.org/wiki/Edward_H._Rulloff
  - MikkoFinell 9y ago
    The study was regarding density, not size.
    - nonbel 9y ago
      Where are you seeing that? Also, fine density/volume/mass, does it really change the argument? There is some optimal size for this region when it comes to certain functions, probably relative to the size of other regions. That size is probably suboptimal when it comes to other functions and there are tradeoffs going on. The press release seems to be assuming that thinner is bad automatically.
      - MikkoFinell 9y ago

huffmsa 9y ago

Not even 3 months ago it was "standing desk users less focused, less productive". Which might be more about the kind of person a standing desk user is than it's effect.

Bakary 9y ago
My anecdotal experience tells me that those who adopt many efficiency boosting methods (standing desks, optimized keyboard layouts, various lifehacks, extreme customization of their work environment…) tend to be less inclined to focus on the actual work.

dombesz 9y ago

I wonder if this is true for physical inactivity in general? I suspect that using a standing desk instead of sitting down wouldn’t change the situation.

jaimex2 9y ago

Anti clickbait tldr: Too much sitting is ASSOCIATED with thinning brain structures.

scotchmi_st 9y ago

> This study does not prove that too much sitting causes thinner brain structures, but instead that more hours spent sitting are associated with thinner regions, researchers said. This is a bit of a non-story. The article doesn't go into what measures were taken to eliminate confounding factors, and it seems from the way it's worded that not many were taken. Maybe people who have a more sedentary lifestyle also tend to come from a lower social background, thus are more prone to physical and mental diseases. Or maybe people who sit more tend to be more obese, and it's really obesity that's associated here. It doesn't take a genius to think up more possible confounding variables. Also, a cohort of 35 people is tiny.

ekianjo 9y ago
> This is a bit of a non-story. You just summed up Science-daily. Every single day there's a revolution in sciences or understanding if you believe their articles.
brownbat 9y ago
> Maybe people who have a more sedentary lifestyle also tend to come from a lower social background My favorite confound is when Pauling convinced many reasonably educated higher SES people that vitamins were a miracle cure-all. Suddenly multivitamins did correlate with higher health outcomes! (Until later studies untangled this and found little broad effect, aside from specific vitamins during pregnancy or specific deficiencies.) Sort of a pop science self fulfilling prophecy. Or when we do things we think are smart, sometimes we pollute the evidence.
- 0n34n7 9y ago
  Pop Science. Nice...
fthssht 9y ago
If this were the first of its kind yes, but given that there are numerous studies suggesting that exercise is good for the brain its reasonable hypothesis. Rather than a non-story I'd say it adds to a body of evidence for a strong hypothesis.

agumonkey 9y ago

what about the dual? moving, either walking, driving or longer always stimulates my brain. To the point that not moving I find myself very silent and believed I had a problem.

z28w 9y ago

Conclusion drawn from experiment on 35 samples? Must be kidding...

always_good 9y ago
Taking issue with small sample sizes is a popular way for the layperson to chime in with criticism, but it is rather empty and uneducated criticism. In statistics, sample size does not tell you if correlations are significant or not. Which is why it's amusing when someone thinks they are being a statistics pedant by pointing out a small sample size.
- projektir 9y ago
  I think this is worth challenging. A small sample means there's a higher likelihood that the sample is not very random. It's often pulled from some easily available source, like a group of college students. An idealized perfect random small sample might be just fine for statistics, but there's little reason to believe that's the sample we're getting. Small samples should be a cause for suspicion.

ourmandave 9y ago

A "sitting is killing you" article based on a study of 35 people. Is this going to launch another wave of conflicting articles published every-other-week saying how to minimize it? "Eat fish 5 times a day while standing!" "New study: fish 10 times while doing squats!" "Latest: the fish does nothing! You need a 'weightless desk' in low earth orbit."

amarant 9y ago
Man that last idea sounds sweet! I'm up for that whether it prolongs my life or not!

kartan 9y ago

"The researchers next hope to follow a group of people for a longer duration to determine if sitting causes the thinning and what role gender, race, and weight might play in brain health related to sitting." This is just a preliminary study. It´s too soon to get any conclusions. But, it´s a good starting point for a hypothesis. I will like to see the results of the final study, even that is going to take a long time. I have seen many times links between sedentary life and illness. But this one looks promising as tries to find a mechanism on why this happens at the brain level that may affect cognition. And yes, before doing a more expensive study, they asked 35 people for a preliminary study. You don´t spend a lot of money to try to prove something without first trying to disprove it on the cheap. Translation for developers: before spending a lot of time to test something you first do a smoke test. If it passes you invest the time to test it fully. Otherwise, you go back to writing code.

netman21 9y ago

In my early career I was a car seat engineer which gave me a life long interest in seats. If you look at historical chairs it is amazing how recently the comfortable chair was introduced. I peg it at around 1920, about 30 years after the Morris chair, which was the beginning. Think of the colonial era Windsor chairs. You can imagine great thinkers sitting in them pulled up to their desks creating and thinking. But no way could you sit for the 10-12 hours a day most HN readers do. Go back further to images of classic times. Sitting devices were definitely not capable of being used for extended periods. So yes, it is worth thinking about the impact of comfortable furniture on how much we sit. But later. I am getting up to get a cup of coffee.

w_t_payne 9y ago
What can we do to support healthy physical posture and movement whilst also maximising productivity when working with with electronic representations of textual and numeric data? There are some obvious avenues to explore -- but it is not clear if anything is going to be available to consumers in the near future.
- jgoodhcg 9y ago
  I'm really hoping VR headsets can provide a workspace where people can lay down or stand. The keyboard replacement in those positions might be hard to figure out.
  - ianai 9y ago
    That’s one of the easier problems. I just bought a split wireless keyboard. It actually feels alright just laying it in my thighs to typ.
- arca_vorago 9y ago
  There are quite a few things that can be done. 1. Get management in on the importance of ergonomics in modern work-life. Like needs to be a large portion of budget and discussed with the board important. 2. Culturally teach the importance of ergonomics in computing. Make it a part of prereq college basic IT courses. 3. Interface types will change this equation. VR, wireless-VR, AR, advances in motion capture, and in brain-computer interfaces will offer alternatives that will have to be adapted and evolved into (I'm rooting for a foss future myself, as it will be more agile in the evolutionary process which is ony one of many reasons foss software is superior to proprietary.) 4. Change the outlook on the desk space and it's function. I was in really good shape in the Marine Corps but I still found time to play pc games, which all know can suck hours away, so I designed a workout program for at the desk in my barracks room. I turned what was a sedentary area into an active area just by changing my approach. For example, during CS matches, the rule was every death is max set of dips (using chair arms) squats (by pushing chair back out of the way) pushups, curls, or pullups, etc. Then rotate every time. I've also used balance balls as chairs in order to force me to focus on my core and ab static strength. There are many examples and each person is different, but the desk doesn't have to be a lazy place. (If you are interested in this I would start with horse stances to work with leg strength first and get the bloodflow to the gluteus maximus which is what excessive sitting restricts.) Ultimately, I've been saying for a while that VR with room sensing seems really promising to me because I envision a future of VR workout sessions, which could be really fun by gamification and get people in shape! It wouldn't be that hard to ship a kettlebell with a motion tracker in it. I have a game project (planned GPLclient/CC?contentbysub model) with a long goal of getting into that territory, but had to narrow scope away from recently. I'm mostly waiting for VR on gnu/linux to get better, hoping the Vive Pro has made progress in that area.

FLUX-YOU 9y ago

I just want a study that tells me the intensity and frequency of exercise that counter-acts the sitting plague. By now, all sitting studies sound like they're stating the obvious.

rtehfm 9y ago
Apparently, there's no _true_ offset for extended hours of sitting[1]. There might be some science/studies behind smart watches urging you to stand for a couple of minutes every hour, however. [1] https://www.theatlantic.com/health/archive/2016/08/the-new-exercise-mantra/495908/ https://www.theatlantic.com/health/archive/2016/08/the-new-e...
- wwayer 9y ago
  A lot of people make a living sitting in a chair all day. What are we all supposed to do instead? The implications of this are pretty far-reaching.
  - always_good 9y ago
    > What are we all supposed to do instead? Depends on how much you care and how able you are to compel yourself into action. Almost every one of us reading this is in a position to abbreviate our work with physical activity at the very least. I just wager that most of us are too addicted to comfort to actually do anything about it in the face of the evidence. For example, we already know that a sedentary lifestyle is bad yet most people don't exercise.

oblib 9y ago

I don't know if my brain has "thinned" but I do know that after sitting for years coding I started experiencing a pinched nerve in my back, and that ain't no fun. I thought I was having a stroke the first time it happened about six months ago. I realized it was a pinched nerve after looking into it but it took several months to figure out exactly what stretches I needed to do to relieve and prevent them.

ianai 9y ago
Where’d you track that info down?
- SuoDuanDao 9y ago
  Not OP, but I actually went to a physiotherapist. Well worth the investment if they know what they're doing.
  - ianai 9y ago
    Very very true. They’ve helped me immensely in the past.
- oblib 9y ago
  Sorry for the slow reply. I read up on the symptoms and since I didn't feel any "pain" it indicated it was a pinched nerve. I started doing some stretches lying on my back and sometimes that stopped the "zinging" immediately but not every time. When it did I could feel my spine in the middle of my back "pop". And if I laid flat on my back I could feel my spine had hump in it. I could also feel some tingling in my feet and legs before it would start zinging me out, so I got to know when they were coming. One day when I felt the tingling I stood up and raised my arms straight up and arched my back backwards as far as I could and slowly lowered my arms by bringing them down while pulling them behind me as far as I could in a half circle motion. All kinds of "popping" noises happened and the tingling went away instantly. Over the next few weeks I had just a few full on zingers and when I did that stretch they went away almost instantly. Since then I've made a point to do those stretches several times a day and I've not had a full blown zinger in over a month. It was bad though. Damn near paralyzing on my left side and I could barely walk when it was happening.

epmaybe 9y ago

Here is the actual paper, for your reference. I'm appalled that ScienceDaily did not link this in their article. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195549 http://journals.plos.org/plosone/article?id=10.1371/journal....

epmaybe 9y ago
Note that in the paper, they mentioned controlling for age. Also mentioned is that this data is preliminary, hence the low sample size.
nonbel 9y ago
Here is the activity survey: http://www.sdp.univ.fvg.it/sites/default/files/IPAQ_English_self-admin_long.pdf http://www.sdp.univ.fvg.it/sites/default/files/IPAQ_English_... The paper was confusing because they reported an average of 7 hours sitting each day and 1500 minutes per week of "physical activity" (3.5 hrs a day). So basically anything besides sitting and sleeping seems to be counted as physical activity. It does sound like almost anything is counted as physical activity: "on how many days did you do moderate activities like carrying light loads, washing windows, scrubbing floors and sweeping inside your home"

HankB99 9y ago

Yes. And television is bad for your eyes. https://www.youtube.com/watch?v=JXCpYgd338U https://www.youtube.com/watch?v=JXCpYgd338U

eruci 9y ago

That's why I'm laying down.

whb07 9y ago

Time and time again more evidence is propping up stating the benefits of exercise. I think Patio11 summed it up well, roughly stating that as we are all working with the same hardware(the body) then we should work to maintain it in top shape. If you maintain your body in a weak state, it would seem that your body would have to maximize its output with a lesser performing system. Imagine trying to perform well when you have a heart that’s got 1/4 the performance of a well maintained one. Imagine the downstream effects of all this!

EGreg 9y ago

This seems to contradict another article posted on HN I read recently, which says memories are lost due to brain cell growth after physical activity! https://www.vox.com/2014/5/8/5695500/why-cant-you-remember-being-a-baby-science-explains https://www.vox.com/2014/5/8/5695500/why-cant-you-remember-b... http://www.sciencemag.org/news/2014/05/how-brain-deletes-old-memories http://www.sciencemag.org/news/2014/05/how-brain-deletes-old... Which contradicts yet another article which says that growing new brain cells can improve memory: http://www.dailymail.co.uk/health/article-1244332/How-running-jog-memory-creating-new-brain-cells.html http://www.dailymail.co.uk/health/article-1244332/How-runnin... So which is it? I think we need scientists to take two contradicting studies and try to find out the root cause of a discrepancy, instead of making a third study. To do that, they need to record as much as they can, and a meta-study needs to look at the actual discrepancies that can account for a change. https://slate.com/health-and-science/2017/06/daryl-bem-proved-esp-is-real-showed-science-is-broken.html https://slate.com/health-and-science/2017/06/daryl-bem-prove...

jaclaz 9y ago
> I think we need scientists to take two contradicting studies and try to find out the root cause of a discrepancy, instead of making a third study. Yes, the shorter form being ;-) : I think we need scientists.

pessimizer 9y ago

Maybe people ages 45 through 75 are going through the period of life which we traditionally associate with both a lowering of physical activity and increasing difficulties in memory. Sure would be nice if they linked the study or seriously cared about critiquing it. The real question should be whether both are also strongly associated with grey hair, number of grandchildren, and taste in film.

pbhjpbhj 9y ago

Interesting they do manual segmenting, who's working on image recognition to automate measuring of the various areas - presumably then all past scans [with patient acceptance] could be fed in to a system and the brain regions could be measured and classified. The correlation graphs are awesome! http://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0195549.g002 http://journals.plos.org/plosone/article/figure?id=10.1371/j... Not sure you could get a better randomisation if you tried with just 35 points??!

nadohs 9y ago

Maybe people with thinning in brain region associate with memory overestimate the amount of time sitting because they can’t recall as accurately what they were doing in between sitting sessions...