6 ms·

Does anyone know where to get it in bulk form? The commercial stuff I've seen seems way overpriced. Also, I'm happy for the disclosure but be wary of potential

Does anyone know where to get it in bulk form? The commercial stuff I've seen seems way overpriced. Also, I'm happy for the disclosure but be wary of potential bias... > The study was partially funded by grants from the National Institutes of Health and the American Federation for Aging Research. ChromaDex, the maker of NIAGEN provided supplements and some financial support.

p0wn 9y ago
As far as I know it's fairly hard to synthesize, and isn't produced in large quantities yet.
- delbel 9y ago
  Smoking cigarettes would do it. Nicotine + Oxygen right? Who knew the movie Sleeper had it right, keto diet and tabacco. https://www.youtube.com/watch?v=D2fYguIX17Q https://www.youtube.com/watch?v=D2fYguIX17Q
  - klipt 9y ago
    Smoking certainly reduces your chance of dying of old age. Mostly by increasing your chance of dying of lung cancer.
    - jackhack 9y ago
      Perhaps an argument for "vaping," then? (Nicotine without the smoke and tar and other nasty compounds in tobacco.) I never thought I would say that.
e9 9y ago
Just use high quality niacin/nicotinic acid/vitamin-b3. "niacin supplementation increases cellular nicotinamide adenine dinucleotide (NAD+) levels" reference: https://examine.com/supplements/vitamin-b3/ https://examine.com/supplements/vitamin-b3/
- truculation 9y ago
  Yes and be prepared for that 'niacin flush' if you take a 500mg capsule the first time. Phew. I had to lie down for half an hour. https://niacinreviews.com/niacin-max-flush/ https://niacinreviews.com/niacin-max-flush/
  - VoiceOfWisdom 9y ago
    Beware the niacin flush. Once I took 500mg, after having already been accustomed to the flush. It hit hard that day though. 15 minutes after taking the pill, while driving, my vision started to narrow and go black. It felt like being chocked out. I was rapidly losing consciousness, but was able to safely pull over to the side of the road. Before completely passing out I was able to vomit up what was left of the pill. I was able to return home, and sleep for the rest of the day. This was with a single 500mg pill, after already being used to the flush.
    - mistermann 9y ago
      FWIW, and not sure if this only helps the itching part of the side effect.... https://www.leaf.tv/articles/how-to-relieve-an-itch-from-niacin https://www.leaf.tv/articles/how-to-relieve-an-itch-from-nia... Drink plenty of water. According to Dr. William Davis, a cardiologist from Wisconsin, ingest 2 8-oz. glasses of water immediately after the itching sensation begins. According to Dr. Davis, this quick task relieves the flush and itching symptoms in more than 90 percent of instances. Take a 325mg table of uncoated aspirin; according to Dr. Davis, this can also alleviate the itching and burning.
  - eljimmy 9y ago
    I had no idea about this before taking it. I popped some before going to the store. Thought I was about to crap myself then started getting super itchy. Had to rush home and by then my entire body was lobster red lol Definitely want to use the non flushing version.
- Zigurd 9y ago
  I have read pieces on NR that claim NR is better at "activating" sirtuin production compared with niacin. Is this a load of baloney? Or is NR really different in its effect?
reasonattlm 9y ago
There are any number of suppliers other than the sole sanctioned one. Search Alibaba. Assume you will pay a fraction of what you'd pay the sanctioned suppliers, but you will also have to run a sample via a LC-MS analysis to see that you are in fact getting what you think you are getting. This is all pretty easy to arrange, and works for just about any well known compound, peptide, etc. If you are willing to do that, one would hope that you are also willing to (a) actually assess the results with the more robust quantified self metrics, rather than just hoping and feeling, as so many people do, and (b) take full responsibility for any harms or legal issues you cause yourself in the course of experimenting, as so few people do. The detailed guides section here contains a couple of posts that walk through this process for a couple of other items, but the same general outline applies in exactly the same way: https://www.fightaging.org/self-experimentation/ https://www.fightaging.org/self-experimentation/
- vondur 9y ago
  I don't think the average person has access to a Mass Spec or Liquid Chromatography equipment.
  - reasonattlm 9y ago
    https://www.scienceexchange.com https://www.scienceexchange.com $100-150 to run a sample through LC-MS via any one of dozens of small laboratory groups. Most are willing to explain things to a newcomer who is working his or her way through learning the ropes.
    - TheSpiceIsLife 9y ago
      I'm often either: a) surprised that processes that seemed futuristic or industrial are available to the average person at a reasonable price or b) surprised that others are surprised I operate a 4kW laser cutter set up to cut metal. Once new customers realise how much product the machine can put out in an hour they understand that it isn't an expensive service, and that it is in fact almost always cheaper to have an item laser cut rather than do it themselves using any of the tools they have in their workshop.
dogma1138 9y ago
Thorne has a fairly cheap one but I’m not sure how much more effective any of those are than high dose B3.
adrr 9y ago
You can't get in bulk. Chromadex stopped all licensing of its patent so you can only buy it from them at $40/m. Chromadex is exploring FDA approval for certain medical conditions so it will be interesting to see if they keep it on the retail market or it becomes prescription only.

p0wn 9y ago

As far as I know it's fairly hard to synthesize, and isn't produced in large quantities yet.

delbel 9y ago
Smoking cigarettes would do it. Nicotine + Oxygen right? Who knew the movie Sleeper had it right, keto diet and tabacco. https://www.youtube.com/watch?v=D2fYguIX17Q https://www.youtube.com/watch?v=D2fYguIX17Q
- klipt 9y ago
  Smoking certainly reduces your chance of dying of old age. Mostly by increasing your chance of dying of lung cancer.
  - jackhack 9y ago
    Perhaps an argument for "vaping," then? (Nicotine without the smoke and tar and other nasty compounds in tobacco.) I never thought I would say that.

e9 9y ago

Just use high quality niacin/nicotinic acid/vitamin-b3. "niacin supplementation increases cellular nicotinamide adenine dinucleotide (NAD+) levels" reference: https://examine.com/supplements/vitamin-b3/ https://examine.com/supplements/vitamin-b3/

truculation 9y ago
Yes and be prepared for that 'niacin flush' if you take a 500mg capsule the first time. Phew. I had to lie down for half an hour. https://niacinreviews.com/niacin-max-flush/ https://niacinreviews.com/niacin-max-flush/
- VoiceOfWisdom 9y ago
  Beware the niacin flush. Once I took 500mg, after having already been accustomed to the flush. It hit hard that day though. 15 minutes after taking the pill, while driving, my vision started to narrow and go black. It felt like being chocked out. I was rapidly losing consciousness, but was able to safely pull over to the side of the road. Before completely passing out I was able to vomit up what was left of the pill. I was able to return home, and sleep for the rest of the day. This was with a single 500mg pill, after already being used to the flush.
  - mistermann 9y ago
    FWIW, and not sure if this only helps the itching part of the side effect.... https://www.leaf.tv/articles/how-to-relieve-an-itch-from-niacin https://www.leaf.tv/articles/how-to-relieve-an-itch-from-nia... Drink plenty of water. According to Dr. William Davis, a cardiologist from Wisconsin, ingest 2 8-oz. glasses of water immediately after the itching sensation begins. According to Dr. Davis, this quick task relieves the flush and itching symptoms in more than 90 percent of instances. Take a 325mg table of uncoated aspirin; according to Dr. Davis, this can also alleviate the itching and burning.
- eljimmy 9y ago
  I had no idea about this before taking it. I popped some before going to the store. Thought I was about to crap myself then started getting super itchy. Had to rush home and by then my entire body was lobster red lol Definitely want to use the non flushing version.
Zigurd 9y ago
I have read pieces on NR that claim NR is better at "activating" sirtuin production compared with niacin. Is this a load of baloney? Or is NR really different in its effect?

reasonattlm 9y ago

There are any number of suppliers other than the sole sanctioned one. Search Alibaba. Assume you will pay a fraction of what you'd pay the sanctioned suppliers, but you will also have to run a sample via a LC-MS analysis to see that you are in fact getting what you think you are getting. This is all pretty easy to arrange, and works for just about any well known compound, peptide, etc. If you are willing to do that, one would hope that you are also willing to (a) actually assess the results with the more robust quantified self metrics, rather than just hoping and feeling, as so many people do, and (b) take full responsibility for any harms or legal issues you cause yourself in the course of experimenting, as so few people do. The detailed guides section here contains a couple of posts that walk through this process for a couple of other items, but the same general outline applies in exactly the same way: https://www.fightaging.org/self-experimentation/ https://www.fightaging.org/self-experimentation/

vondur 9y ago
I don't think the average person has access to a Mass Spec or Liquid Chromatography equipment.
- reasonattlm 9y ago
  https://www.scienceexchange.com https://www.scienceexchange.com $100-150 to run a sample through LC-MS via any one of dozens of small laboratory groups. Most are willing to explain things to a newcomer who is working his or her way through learning the ropes.
  - TheSpiceIsLife 9y ago
    I'm often either: a) surprised that processes that seemed futuristic or industrial are available to the average person at a reasonable price or b) surprised that others are surprised I operate a 4kW laser cutter set up to cut metal. Once new customers realise how much product the machine can put out in an hour they understand that it isn't an expensive service, and that it is in fact almost always cheaper to have an item laser cut rather than do it themselves using any of the tools they have in their workshop.

dogma1138 9y ago

Thorne has a fairly cheap one but I’m not sure how much more effective any of those are than high dose B3.

adrr 9y ago

You can't get in bulk. Chromadex stopped all licensing of its patent so you can only buy it from them at $40/m. Chromadex is exploring FDA approval for certain medical conditions so it will be interesting to see if they keep it on the retail market or it becomes prescription only.