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This is a highly misleading presentation of the study. The study compared the following doses: — 400 mg ibuprofen and 1,000 mg acetaminophen — 5 mg oxycodone

This is a highly misleading presentation of the study. The study compared the following doses: — 400 mg ibuprofen and 1,000 mg acetaminophen — 5 mg oxycodone and 325 mg acetaminophen — 5 mg hydrocodone and 300 mg acetaminophen; or — 30 mg codeine and 300 mg acetaminophen https://media.jamanetwork.com/news-item/no-significant-difference-pain-relief-opioids-vs-non-opioid-analgesics-treating-arm-leg-pain/ https://media.jamanetwork.com/news-item/no-significant-diffe... So, the study is comparing high doses of ibuprofen/acetaminophen to low doses on opiates/acetaminophen. It is an interesting outcome for mild pain and suggest that for mild pain it might be better to pass on low dose opiates but in no way does this show that opiates are not needed for severe pain.

pilsetnieks 9y ago
400 mg ibuprofen and 1000 mg acetaminophen aren't high doses, at least when taken separately, they're pretty standard adult doses (I think those are also the most common pill dosages.)
- iliketosleep 9y ago
  Maximum single does of standard release acetaminophen is 1000 mg. Make no mistake, that is a high dose and it's terrible for your liver. That's why in recent years, there are more and more 325 mg preparations (where an adult takes 2 x 325) rather than the traditional 2 x 500 mg.
copperx 9y ago
I dare them to repeat the study with metastatic cancer patients. I'll give them three days before the IRB cancels everything.