5 ms·
NAD+ could regulate aging, may explain rejuvenation
- mkempe 9y agoHere is the description via Harvard: "Critical step found in DNA repair, cellular aging" [1] [1] http://news.harvard.edu/gazette/story/2017/03/harvard-scientists-pinpoint-critical-step-in-dna-repair-cellular-aging/ http://news.harvard.edu/gazette/story/2017/03/harvard-scient...
- mkempe 9y agoThe high-dosage NMN (boosting production of NAD+) fed to mice via drinking water appears to be 300 mg/kg of bodyweight/day. How much would it cost to produce 5 grams per day (adjusted for a couple of humans)? and how could a regular, motivated (software) engineer learn to do it? Edit: adjusted the dose to 1/12th for mice-to-human adjustment, we're looking at 5g NMN/day for a couple (not 50g).
- cwisecarver 9y agoRelated: https://www.elysiumhealth.com https://www.elysiumhealth.com I've been taking this for about 6 months. Haven't noticed much other than better sleep, easier to wake upon time feeling refreshed.
- mkempe 9y agoThat's NR, not NMN. Also, the daily Elysium dose of NR is 500mg, much less in proportion to body weight than what was fed to the mice in this Harvard study. Added: Thanks to jclos below. The human-mouse-equivalent NMN dose would be 1/12th, 25mg/kg of bodyweight/day.
- cwisecarver 9y agoIt does boost production of NDA+ though, right?
- mkempe 9y agoYes, but the dose must be important. Brenner [1] took 1g NR/day for 7 days during his self-study. [1] https://medcom.uiowa.edu/theloop/news/first-human-clinical-trial-for-nicotinamide-riboside https://medcom.uiowa.edu/theloop/news/first-human-clinical-t...
- jclos 9y agoKeep in mind that there is no 1:1 mapping between mg/kg/day for mice and for humans due to difference in metabolism. http://www.ergo-log.com/calculatethehumandosage.html http://www.ergo-log.com/calculatethehumandosage.html gives a couple of useful formulas to calculate the actual dosage for humans and it's much more reasonable.
- TrainedMonkey 9y agoHaving done some ECLSS stuff it takes about 13 mice to equal metabolic load of a human. This does not add up if you use mass alone, but comes out pretty close using volume/surface area metric.
- caycep 9y agothat being said, NAD is so ubiquitous that I can't imagine it is the only factor. It's may be more akin to saying if you use Chevron gas with techron vs. Arco gas, that your engine may last another 5,000 miles or something. But it doesn't address primary causes of engine failure based on design, engineering, etc.
- fiter 9y agoI don't think a car analogy is apt because a car isn't self-repairing like many biological processes.