7 ms·
There are some interesting theories about aspirin. For example that it was Rasputin's secret healing trick to tell people to stop taking it: "Gilliard,[32] the
by nonbel 10y ago
There are some interesting theories about aspirin. For example that it was Rasputin's secret healing trick to tell people to stop taking it:
"Gilliard,[32] the French historian Hélène Carrère d'Encausse[33] and Diarmuid Jeffreys, a journalist, speculated Rasputin's healing practice included halting the administration of aspirin, a pain-relieving analgesic available since 1899.[34] Aspirin is an antiaggregant and has blood-thinning properties; it prevents clotting, and promotes bleeding which could have caused the hemarthrosis. The "wonder drug" would have worsened Alexei's joints' swelling and pain.[35][36]"
https://en.wikipedia.org/wiki/Alexei_Nikolaevich,_Tsarevich_of_Russia https://en.wikipedia.org/wiki/Alexei_Nikolaevich,_Tsarevich_...
It is also claimed to be the real cause of the "Spanish flu":
"The high case-fatality rate—especially among young adults—during the 1918–1919 influenza pandemic is incompletely understood. Although late deaths showed bacterial pneumonia, early deaths exhibited extremely “wet,” sometimes hemorrhagic lungs. The hypothesis presented herein is that aspirin contributed to the incidence and severity of viral pathology, bacterial infection, and death, because physicians of the day were unaware that the regimens (8.0–31.2 g per day) produce levels associated with hyperventilation and pulmonary edema in 33% and 3% of recipients, respectively. Recently, pulmonary edema was found at autopsy in 46% of 26 salicylate-intoxicated adults. Experimentally, salicylates increase lung fluid and protein levels and impair mucociliary clearance. In 1918, the US Surgeon General, the US Navy, and the Journal of the American Medical Association recommended use of aspirin just before the October death spike. If these recommendations were followed, and if pulmonary edema occurred in 3% of persons, a significant proportion of the deaths may be attributable to aspirin."
https://academic.oup.com/cid/article/49/9/1405/301441/Salicylates-and-Pandemic-Influenza-Mortality-1918 https://academic.oup.com/cid/article/49/9/1405/301441/Salicy...
- benji-york 10y ago> 8.0–31.2 g per day That is surprising amount of aspirin.
- jszymborski 10y agoyou know what they say, ten aspirin tablets a-day keeps the emergency room busy.
- Reason077 10y agoEven a small amount of Asprin, if taken regularly, will mess up your stomach in my experience! I guess not everyone is sensitive to it, but for me I've avoided Asprin (and Ibuprofen, another NSAID drug) for years because of this.
- mixmastamyk 10y agoI come from a long line of iron-stomachs who don't bat an eyelash at any of those. ;)
- mod 10y agoWhat's 'regular?' I use ibprufen exclusively, without stomach issues. But not daily. I probably take it once per week on average. Usually when lacking caffeine has caused a headache. Or eyestrain, occasionally. Those are probably the issues I should fix, though.
- oxide 10y ago>But not daily. I probably take it once per week on average. My grandmother shits and pukes blood if she takes NSAIDs of any kind, from long-term, daily misuse. I'm not exaggerating even a little bit, I wish I was. A direct result of being denied access to proper pain relief, mind you, mainly because she lived her entire life without health insurance. Until she turned 65 and qualified for Medicare last year. I had to take every NSAID out of the house, and throw them away, because every time she ran out of opiates for pain relief she'd over-compensate with a handful of NSAIDs which resulted in some scary events, including coffee ground bowel movements which were in fact blood from her stomach. As well as constant vomiting, etc. My grandfather is similarly damaged from being recklessly over-prescribed NSAIDs, namely 800mg ibuprofen up to 8 times per day, resulting in shitting and puking up blood. He can't have more than an 81mg aspirin now. /anecdotal evidence
- taneq 10y agoAfter surgery I was prescribed an NSAID called Naproxen. It's apparently much easier on the stomach than Ibuprofen, but has a very slightly higher chance of causing a heart attack or stroke. I think this is one of those situations where they'd rather a thousand people be miserable and wreck their stomachs than one person drop dead and cause a lawsuit.
- salmonet 10y agoI would go out on a limb and say it's a LOT of Asprin. I usually use "surprising" on HN because anything more specific gets criticized surprisingly often, but that is a ton of asprin
- oxide 10y agoit's a veritable fuck-ton. the usual modern dose is 325mg.
- joelthelion 10y agoIn the US. It's higher in France, for example.
- libdong 10y agoThe maximum daily dose is usually around 4g. 325mg is probably the dose in one tablet.
- joshgel 10y agoDoctor here: very rarely does any prescribe anything more than 325mg daily. Most people get 81mg daily. 325mg is considered high dose. You are correct that it can be written for more, but the only indication you would prescribe a higher dose is as a pain or fever reducer, and we have more effective NSAIDs for that. Or tylenol (?NSAID). I've personally never seen it given more than 325mg daily.