5 ms·

How the Brain Dumps Its Trash (2016) [video]

130 points by lobo_tuerto 10y ago

DrScump 10y ago
(March 2016, video)
- dang 10y ago
  Thanks! Added above.
teperpencoli 10y ago
Anyone have a tl;dr?
- majkinetor 10y ago
  Its tl/dw I guess
- quickben 10y ago
  From other sources, while you sleep the brain changes permeability to allow stuff to be flushed out. I'm sorry I can't watch this vid now so it may be having different take/information.
- cheeko1234 10y ago
  Recent research shows that a major function for sleep may be to facilitate the brain’s janitorial functions. Waste products and the detritus of daily thinking can be removed during nightly sleep. This cleaning function allows our brains to work properly and may account for why we generally feel brighter and happier in the mornings. Other organs and tissues are "cleaned" using the lymphatic system that almost works as a sewage system for the body. The lymphatic system does not extend into the brain. The so-called "blood-brain barrier" limits fluid channel exchanges between the brain and the rest of the body to protect the brain. The extracellular fluid in the brain – the wetness between the neurons – is part of a system that essentially flushes the brain and removes waste. This has been named the glymphatic system. It was previously thought that waste products were metabolized and broken down by the neurons themselves and the results of that breakdown carried away in capillaries and ultimately removed by the kidneys. http://www.sleepdex.org/reboot.htm http://www.sleepdex.org/reboot.htm
tilt_error 10y ago
She repeatedly says "the brain does not have a lymphatic system", but wasn't that discovered to be incorrect prior to this video recording? What am I missing?
- majkinetor 10y ago
  As a reference: http://neurosciencenews.com/lymphatic-system-brain-neurobiology-2080/ http://neurosciencenews.com/lymphatic-system-brain-neurobiol...
- godmodus 10y ago
  I too thought synapses clean themselves during deep sleep, just not that we'll understood. And as far the lymph system + brain article(0) links =>(0) 2015 https://www.nih.gov/news-events/nih-research-matters/lymphatic-vessels-discovered-central-nervous-system https://www.nih.gov/news-events/nih-research-matters/lymphat...
amelius 10y ago
Is this also how substances like caffeine get removed from the brain?
- pizza 10y ago
  No. Drug-breakdown processes have long been studied, whereas this is something new. Drugs like caffeine are removed by metabolic enzymes in multiple stages - e.g. here is a flowchart of caffeine's metabolic pathway https://s3.pgkb.org/pathway/PA165884757.png?versionId=XtszC77mTsmQlNujJSxYCeTW_V2XnLNw https://s3.pgkb.org/pathway/PA165884757.png?versionId=XtszC7...
  - semi-extrinsic 10y ago
    But that's not how caffeine is removed from the brain - that entire flowchart says "liver cell". Is one to understand that as the liver cleans blood of caffeine, and this low-caffeine blood eventually goes up to the brain, caffeine diffuses somehow (across the blood/brain barrier) into the bloodstream and is then carried to the liver?
    - pizza 10y ago
      Essentially, to my knowledge.. of relevance: https://en.wikipedia.org/wiki/Distribution_(pharmacology) https://en.wikipedia.org/wiki/Distribution_(pharmacology) https://en.wikipedia.org/wiki/Pharmacokinetics https://en.wikipedia.org/wiki/Pharmacokinetics https://en.wikipedia.org/wiki/ADME https://en.wikipedia.org/wiki/ADME https://en.wikipedia.org/wiki/Compartment_(pharmacokinetics) https://en.wikipedia.org/wiki/Compartment_(pharmacokinetics) https://en.wikipedia.org/wiki/Clearance_(pharmacology) https://en.wikipedia.org/wiki/Clearance_(pharmacology) https://en.wikipedia.org/wiki/Plasma_protein_binding https://en.wikipedia.org/wiki/Plasma_protein_binding
saxonklaxon 10y ago
Apart from getting enough sleep, any tips for how to support or enhance this maintenance process?
- pizza 10y ago
  My very uninformed and probably incorrect hunch is to increase the amount of water flow in your body before bed - i.e. drink a glass of water or two. Counterbalance in the case of any frequent urges to wake up in the middle of the night to urinate..
jon2k17 10y ago
anyone have a transcribed version of this?

130 points by lobo_tuerto 10y ago

DrScump 10y ago

(March 2016, video)

dang 10y ago
Thanks! Added above.

teperpencoli 10y ago

Anyone have a tl;dr?

majkinetor 10y ago
Its tl/dw I guess
quickben 10y ago
From other sources, while you sleep the brain changes permeability to allow stuff to be flushed out. I'm sorry I can't watch this vid now so it may be having different take/information.
cheeko1234 10y ago
Recent research shows that a major function for sleep may be to facilitate the brain’s janitorial functions. Waste products and the detritus of daily thinking can be removed during nightly sleep. This cleaning function allows our brains to work properly and may account for why we generally feel brighter and happier in the mornings. Other organs and tissues are "cleaned" using the lymphatic system that almost works as a sewage system for the body. The lymphatic system does not extend into the brain. The so-called "blood-brain barrier" limits fluid channel exchanges between the brain and the rest of the body to protect the brain. The extracellular fluid in the brain – the wetness between the neurons – is part of a system that essentially flushes the brain and removes waste. This has been named the glymphatic system. It was previously thought that waste products were metabolized and broken down by the neurons themselves and the results of that breakdown carried away in capillaries and ultimately removed by the kidneys. http://www.sleepdex.org/reboot.htm http://www.sleepdex.org/reboot.htm

tilt_error 10y ago

She repeatedly says "the brain does not have a lymphatic system", but wasn't that discovered to be incorrect prior to this video recording? What am I missing?

majkinetor 10y ago
As a reference: http://neurosciencenews.com/lymphatic-system-brain-neurobiology-2080/ http://neurosciencenews.com/lymphatic-system-brain-neurobiol...
godmodus 10y ago
I too thought synapses clean themselves during deep sleep, just not that we'll understood. And as far the lymph system + brain article(0) links =>(0) 2015 https://www.nih.gov/news-events/nih-research-matters/lymphatic-vessels-discovered-central-nervous-system https://www.nih.gov/news-events/nih-research-matters/lymphat...

amelius 10y ago

Is this also how substances like caffeine get removed from the brain?

pizza 10y ago
No. Drug-breakdown processes have long been studied, whereas this is something new. Drugs like caffeine are removed by metabolic enzymes in multiple stages - e.g. here is a flowchart of caffeine's metabolic pathway https://s3.pgkb.org/pathway/PA165884757.png?versionId=XtszC77mTsmQlNujJSxYCeTW_V2XnLNw https://s3.pgkb.org/pathway/PA165884757.png?versionId=XtszC7...
- semi-extrinsic 10y ago
  But that's not how caffeine is removed from the brain - that entire flowchart says "liver cell". Is one to understand that as the liver cleans blood of caffeine, and this low-caffeine blood eventually goes up to the brain, caffeine diffuses somehow (across the blood/brain barrier) into the bloodstream and is then carried to the liver?
  - pizza 10y ago
    Essentially, to my knowledge.. of relevance: https://en.wikipedia.org/wiki/Distribution_(pharmacology) https://en.wikipedia.org/wiki/Distribution_(pharmacology) https://en.wikipedia.org/wiki/Pharmacokinetics https://en.wikipedia.org/wiki/Pharmacokinetics https://en.wikipedia.org/wiki/ADME https://en.wikipedia.org/wiki/ADME https://en.wikipedia.org/wiki/Compartment_(pharmacokinetics) https://en.wikipedia.org/wiki/Compartment_(pharmacokinetics) https://en.wikipedia.org/wiki/Clearance_(pharmacology) https://en.wikipedia.org/wiki/Clearance_(pharmacology) https://en.wikipedia.org/wiki/Plasma_protein_binding https://en.wikipedia.org/wiki/Plasma_protein_binding

saxonklaxon 10y ago

Apart from getting enough sleep, any tips for how to support or enhance this maintenance process?

pizza 10y ago
My very uninformed and probably incorrect hunch is to increase the amount of water flow in your body before bed - i.e. drink a glass of water or two. Counterbalance in the case of any frequent urges to wake up in the middle of the night to urinate..

jon2k17 10y ago

anyone have a transcribed version of this?