4 ms·
I've never done it, but I think those are just naturally bred out by breeding healthy mice from each successive generation.
by ghkbrew 10y ago
I've never done it, but I think those are just naturally bred out by breeding healthy mice from each successive generation.
- Someone 10y agoMany of the strains they sell aren't healthy. If you enter a condition or disease like 'lung cancer' or 'paralysis' in https://www.jax.org/mouse-search https://www.jax.org/mouse-search, you'll find they sell a mouse that's susceptible to a form of it. For example, https://www.jax.org/strain/004863 https://www.jax.org/strain/004863: "Homozygous Snap25 knock-out mice exhibit neonatal lethality. Late embryos lack spontaneous movement or sensorimotor reflexes, and abnormal innervation and muscle fiber development is observed." Breeding mice that die at birth is an unsolved problem I'm sure they are thinking of, so they sell the heterozygous variant (carriers of the gene)
- ralfd 10y ago> Breeding mice that die at birth is an unsolved problem I'm sure they are thinking of That sentence is both horrible, absurde, macabre and logical at the same time.