> but what are some possible evolutionary reasons for this connection? With long term phenotypes like brain health, there probably isn't enough selective press

> but what are some possible evolutionary reasons for this connection? With long term phenotypes like brain health, there probably isn't enough selective pressure to create or maintain this relationship. Rather this result is likely the result of coincidence, and that coincidence was not deleterious enough to be removed by selection. Ex : Exercise stimulates repair enzymes > Excess Repair Enzymes Filter Into Blood Stream > Excess Repair Enzymes Also Fix Brain Cells.