>This goes back to the phenotypic screening argument. Truth. Domagk would have missed sulfa all together if he had been using an in-vitro strep model. Prontos

>This goes back to the phenotypic screening argument. Truth. Domagk would have missed sulfa all together if he had been using an in-vitro strep model. Prontosil (what Donmagk discovered), and azodye connected to a sulfa molecule, must be enzymatically digested into the individual azo and sulfa molecules before it becomes biologically active. Sometimes reduction of a problem, looses the problem all together.