3 ms·
Both this result and the preceding paper are also entirely consistent with the hypotheses that: 1) People who are susceptible to vCJD are more susceptible to A
by alexholehouse 11y ago
Both this result and the preceding paper are also entirely consistent with the hypotheses that:
1) People who are susceptible to vCJD are more susceptible to AD
2) The (cellular) stress caused by vCJD increases susceptibility for AD
3) People who have had brain surgery (a traumatic and stressful experience in terms of brain swelling) are more susceptible to AD
All three of which would be entirely inline with the fields' current way of thinking about AD, proteostasis, CBI etc. Which is not to say I actually don't think that there is a transmissible element, but I think we should avoid jumping to conclusions...
- pc2g4d 11y agoBut what about the CJD controls that didn't receive transplants derived from cadaver tissue? Those didn't show the same rate of Alzheimers-like plaques, if I understood the report correctly.
- alexholehouse 11y agoThe CJD controls had sporadic (sCJD), not variant CJD (vCJD) (whether or not these are distinct diseases is certainly an open question - I'm more trying to make the point that there are a lot of variables up in the air, and while it's a striking relationship there are other equally striking relationships one could draw).
- pc2g4d 11y agoA good note of caution for any study.