4 ms·
>The results may be negative, but they are valid results. Except they were mostly (if not all) uncontrolled. Uncontrolled trials for depression are bad science
by cpncrunch 11y ago
>The results may be negative, but they are valid results.
Except they were mostly (if not all) uncontrolled. Uncontrolled trials for depression are bad science, because the placebo effect has such a large effect. Even if an open-label trial for depression is successful, it tells you absolutely nothing.
- caycep 11y agoThe one cited in the link was controlled and blinded using sham stimulation in the group. The problem isn't that it wasn't controlled, it may not have been powered (n=30ish?) enough to reliably detect a difference...which is the main bugaboo in clinical science. Recruiting enough people into the study to make it meaningful is the hard and expensive part.