My own mail-server, accessed via desktop/mobile client. I also have GnuPG support on the desktop client. That's as good as it gets. If I had to use a web-based

My own mail-server, accessed via desktop/mobile client. I also have GnuPG support on the desktop client. That's as good as it gets. If I had to use a web-based mail client, I would go with mailpile.js although it's far from a complete replacement.