3 ms·
Assuming we're talking veni-puncture based measurements ,can you please expand about the current technical hurdles of microfluidics, and what prevents them from
by petra 11y ago
Assuming we're talking veni-puncture based measurements ,can you please expand about the current technical hurdles of microfluidics, and what prevents them from being solved , even after 20 years+ of effort by the research community ?
And all those interesting research paper ,we're seeing from the academic community, aren't they targeting the issue ? or are mostly resume fillers ?
- joezydeco 11y agoI'm not a biochemist, and it's been too long ago when I worked there to comment on what the current state of the art is in this area. What I recall is that at the microfluidic level, a lot of the work becomes a mechanical issue not a biochemical one. You're working with very small samples in a disposable system (obviously cleaning a capillary between samples is practically impossible). Blood isn't the easiest substance to work with, especially when trying to move it through small channels. On top of that, now you're trying to detect very small amounts of antigen in an even tinier sample size. Your technology needs to be incredibly sensitive but have a decent resolution as well. Some antigens you want a simple positive/negative outcome. But with some other tests you want a level or range (like thyroid).