zosima

26 ms·

301.
by zosima 7y ago
The article is not quite updated. Biogen did end their phase 3 trial of the amyloid-beta antibody Aducanumab early, citing lack of efficacy. A closer look at the numbers however appeared to reveal that they shouldn't have. And Biogen i
302.
by zosima 7y ago
True, the default semantics of R's data structures are somewhat arcane (of course as they're based on S [1] from the 70's). And the current support for e.g. 64bit integers leaves something to be desired. But behind the scenes
303.
by zosima 7y ago
This is not correct. In case Monty opens a random door which may or may not have the prize behind it, there is no reason to switch. Probability table is: 1/3 chance you pick the prize on first choice. (And Monty opens a random goat-doo
304.
by zosima 10y ago
This is wrong. Casting to and from void * is defined for all pointer types except function pointers, according to the standard. Otherwise most every assignment after call to malloc would be undefined.
305.
by zosima 13y ago
No, that's not quite right. Randomly picking people from a distribution should eventually end up giving the original distribution. Taking n people from a pool m times, then the means of those m samplings will be normally distributed h
306.
by zosima 14y ago
Doctors may just use the drug off-label. If the patient responds then they use the drug, otherwise they try something else. A formal trial really helps very little in these cases. If a bunch of clinicians find that the drug is effective aga
307.
by zosima 14y ago
You can probably add every single feature in emacs to sublime. The 30 earth-years and many, many man-years of features, additions and smoothing of interactions that has gone into emacs, will however take quite some time to come to par with.
308.
by zosima 14y ago
Translated directly, yes. But when you have objects and no piping operator, library designers will often choose to implement pipe flow as method chaining. See e.g. jQuery, Scala's collections or many ORMs, like SQLAlchemy.
309.
by zosima 14y ago
Sloppy me. I would of course be referring to arithmetic syntax or notation. And you make my point exactly: there is many ways to express arithmetically heavy operations in a natural, readable way.
310.
by zosima 14y ago
Yes, many languages support something eqivalent. Classically object oriented languages not the least: a.h().g().f() I feel that prefix notation is one of the greatest impediment to the uptake of Lisps. And I think it's important to undersco
311.
by zosima 14y ago
Most Lisps aren't so great with arithmetic. Afterall arithmetic notation has been refined through 100's of years to be readable and concise, and I've never seen anybody use prefix notation for operators voluntarily. But infix notation can b
312.
by zosima 14y ago
> Religious schism had little to no bearing on the sudden development of trade and exploration in the renaissance, both of which opened the New World. The spanish fight against the moslems was certainly immediately temporally connected.
313.
by zosima 14y ago
Yes, this is an interesting effect of capitalism: locally significant but globally quite irrelevant issues gets more resources allocated to them than globally significant but not locally sensible investments. That's of course bad. The immed
314.
by zosima 14y ago
From the linked article in the OP: "An official at the Health Ministry's statistics bureau said Friday's survey does not change Japan's status as a fast-aging nation because life expectancy calculations are not based on family registration
315.
by zosima 14y ago
The article is fluffy and wrong. Writers, composers and programmers all get better from doing. For each new program written, you expand your style, your vocabulary and learn to express yourself in a simpler and more precise manner. This ena
316.
by zosima 14y ago
Well, ideas are constantly being heavily pruned and cut to the ground on hacker news. And some of that pruning is good and necessary. Otherwise, bad ideas would proliferate and take air and light from the good ideas. But often when I read H
317.
by zosima 14y ago
He coined a nice epigram I will remember. That is enough for the article to be interesting. What is the problem with being self-congratulatory? What is wrong with focusing on the positive and thinking that your hobby and life's work is wort
318.
by zosima 14y ago
It is worth noting that method for producing the data 1900-2010 data and the 0-1900 data in the top graph is wildly different. First and foremost: The black line is an actual temperature measurement, while all the other lines are estimates
319.
by zosima 14y ago
The reconstructions by proxy referred to by gd1 leads to a hockey stick as far as back as you can go. Expect of course were there is very sparse proxy data at which point the trends will be completely random. The cousin refers to the obviou