yarcob

33 ms·

301.
by yarcob 6y ago
There's also SRAM that have group sets at every price point, and some smaller manufacturers like Campagnolo or Sunrace.
302.
by yarcob 6y ago
> Probably only beneficial if you have one copy, not two. One copy of the gene partially protects you from malaria; two copies of the gene make you very sick. That's why even in Africa only a small portion of the population has the
303.
by yarcob 6y ago
The nice thing about CRISPR is that you can use pretty long sequences for matching, so in theory you can just pick a sequence that doesn't occur anywhere else and cut there. (Before CRISPR, you would use restriction enzymes with a shor
304.
by yarcob 6y ago
The technique sounds promising, since it avoids the typical problem of gene therapy, which is how to get CRISPR past the immune system into every cell in the body. With this technique you can do the CRISPR procedure in vitro. A big downside
305.
by yarcob 6y ago
TLDR: 1) Extract bone marrow from patient 2) Use CRISPR to fix broken gene in the extracted bone marrow 3) Use chemo to destroy old bone marrow in patient 4) Transplant fixed bone marrow from step 2 back into the patient
306.
by yarcob 6y ago
I'm pretty sure I could deal with my commuting app being down for planned maintenance once a year for 3 hours. Especially if I got prior notification. What's a good time for outage? I don't know anything about your app. You c
307.
by yarcob 6y ago
> Downtime for upgrades impacts everyone. Just because you're small scale doesn't mean your users don't expect (possibly contractually) availability. I don't understand this mindset. Every tiny startup thinks they nee
308.
by yarcob 6y ago
And judging by the blog post he's a talented technical writer as well.
309.
by yarcob 6y ago
Good point. Please note that I wrote: "There's nothing wrong with needing some special accomodations". I did not say you need to accomodate everything. If someone is drunk enough that he's going to piss and throw up in t
310.
by yarcob 6y ago
She lost her job and probably a lot of time fighting this court case. I don't think breaking it down per ride is a good way to look at it.
311.
by yarcob 6y ago
I think you are giving service providers way too much leeway. Service providers should offer their service to everyone, not just to "easy" customers. Service providers should not reject you because you are disabled, because you ha
312.
by yarcob 6y ago
Oh my god that's bad. What a dumpster fire. - nauseating animaton - nervous animated chevron that looks clickable but isn't - scroll down to be greeted by a "youtube face" - feature descriptions written in light grey tex
313.
by yarcob 6y ago
Here in Austria there is a free phone app (Handysignatur) that allows you to authenticate to a variety of services. It's a two factor system, so someone would need to steal both your phone and your password to impersonate you. For init
314.
by yarcob 6y ago
> a cloud is a necessity For whom? It's a necessity for software vendors, because they finally have an easy and straightforward way to bill per user. Nobody needs a cloud based solution, running software on a local machine is a pe
315.
by yarcob 6y ago
> Use a third party music player. Any recommendations?
316.
by yarcob 6y ago
On classic vinyl releases you got a single record with roughly 20 minutes of music on each side. They recorded the album so it fit nicely on two sides. With new releases the vinyl is usually an afterthought, so it usually doesn't fit n
317.
by yarcob 6y ago
I buy Vinyl, but most new Vinyl releases suck. They just stuff a bunch of songs on 3 or 4 sides that end up half empty, so you need to flip the record all the time.
318.
by yarcob 6y ago
I care about album art and am frustrated with both Apple and Spotify. Does anyone have suggestions where I should direct my buying power so I can listen to music and view high res album art?
319.
by yarcob 6y ago
It doesn't go away with Apple Music, they just shove their explore features in your face, and the experience for listening to your favorite artists still sucks.
320.
by yarcob 6y ago
Both Spotify and Apple Music make it really hard to see album art. It seems they just don't care about it. They show tiny thumbnails, and there's no way to make it bigger. But it's not like artists care either. 99% of artist
321.
by yarcob 6y ago
> Why is everyone acting like this is some high conspiracy Because everyone here is a coder and puts a lot of effort into their work, and doesn't want it get stolen. We put a lot of effort into the Open Source projects we publish. S
322.
by yarcob 6y ago
> TTL is irrelevant for the first query With a long TTL, the chances are higher that your router or your ISP has the name cached. Round trip to your ISP is very short. If you have a short TTL, the ISPs name server may have to query the n
323.
by yarcob 6y ago
> aren't DNS queries a drop in the bucket compared to the size of most web pages anyway? The client needs to wait for the result of a DNS query before it can do anything else. The bandwidth is irrelevant, the problem is the delay. U
324.
by yarcob 6y ago
The point of my story was not that the police are racist. The point was that racism is sometimes invisible to people who are not personally affected. This point is universal and it doesn't matter on which side of the Atlantic it happen
325.
by yarcob 6y ago
The problem is that the chinese knockoffs don't work as well, don't even look similar, but are advertised by fraudsters with marketing materials stolen from the original product. This is not a case of someone making a cheaper vers
326.
by yarcob 6y ago
Black Lives Matter protests were in several European cities as well. Not as big as in the US, of course. But racist police are a world wide problem, it's not something limited to the US.
327.
by yarcob 6y ago
> Almost all of the oppression we see around us can be explained by wealth disparities I recently talked to a mom who visited her adult foster daughter with a different skin tone. Her daughter reminded her to make sure she doesn't f
328.
by yarcob 6y ago
You should try it. I found it very enlightening to find out how utterly incapable I was to get away with a pretend murder in a primitve computer game with random strangers. (Even if like me you won't end up playing the game I found the
329.
by yarcob 6y ago
There's a difference between "freely expressing your ideas" and eg. plotting a vigilante kidnapping. The former should be protected, the latter should be reported to the police. A lot of the people who say they want free spee
330.
by yarcob 6y ago
I'm starting to wonder why they don't just install proper toilets in the delivery vans. Those vans should be big enough, and while camping toilets are a bit gross, they're a lot better than peeing in a bottle.

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