w10-1

48 ms·

631.
by w10-1 2y ago
This drug combines 3 targets per phase 2 docs [1]. Weight loss and side-effects both show dose-response relations. Side-effects could be higher than single-target drugs d/t more off-target effects, or they could be lower if per-target
632.
by w10-1 2y ago
It looks like "Super-alignment" was to automate monitoring, and their job was to find AI researchers who wanted not to build new things but find problems. But there's really zero glory or profit in doing QA, much as users com
633.
by w10-1 2y ago
As another data point, IBM WebSphere had an open-source version and a paid version which used AspectJ (AOP) to deploy proprietary features. People could deploy something like that potentially even at runtime via remote libraries and load-t
634.
by w10-1 2y ago
> Since GPT-4 launch, token prices are falling 84% per year!! Good for mankind, but crazy for these companies The message to competitor investors is that they will not make their money back. OpenAI has the lead, in market and mindshare;
635.
by w10-1 2y ago
With a voxel size of 2x2x8mm^3, this would do what X-rays/CT's do now, and a bit more (but likely not replace high-energy MRI's? I'm not understanding how they rival high-energy accuracy in-silico, but that's how th
636.
by w10-1 2y ago
> the market is oversaturated by apps that are nothing more than a skin over ChatGPT OpenAI et al expressly don't care about small applications, but will do deals e.g., with Apple. So aside from humanity-wide applications, AI comme
637.
by w10-1 2y ago
Yes, you'll expend resources to protect resources, but that's not the issue. NIMBY is always an argument about character, not price. You live where you live -- meaning you can't avoid the influences around you. So you pick a
638.
by w10-1 2y ago
For the heap, JEP 454 is reasonably detailed: https://openjdk.org/jeps/454 It describes how to adopt memory from C and have C adopt memory you allocate, and gives control over how memory is allocated in an arena. The
639.
by w10-1 2y ago
I think Cmkr fails to state its value proposition by focusing on how it works. Any system like CMake that wraps boatloads of complexity is going to have unexpected interactions and inscrutable failures. The question for any developer who do
640.
by w10-1 2y ago
Also function pointers, errors & exception-handling, async/channels/thread-local's, go stacks, swift @objc, @cdecl and cpp inter-op, FFI dialects... It's not really pain anymore; it's a kind of hilarity
641.
by w10-1 2y ago
I'm not sure determinism alone is sufficient for proper attribution. This presumes "chunks" are the source. But it's not easy to identify the propositions that form the source of some knowledge. In the best case, you a
642.
by w10-1 2y ago
Risk is lost in the discussion but very relevant to management. In theory, in the most productive engineering organization, each person is the expert at what they're doing and work is factored to avoid overlap. This happens somewhat n
643.
by w10-1 2y ago
I've considered using CoreMotion data from AirPods to recognize at least yes/no head-shaking, but mainly targeting a vigorous shake in order to mute without hands or voice. An open-source example would be a great starting-point!
644.
by w10-1 2y ago
It may be politics. 90% of AM radio stations are owned by ~5 companies pushing a conservative agenda, with a similar disparity in programming (i.e., 90% conservative). Most of the 10% of non-conservative stations are in progressive markets,
645.
by w10-1 2y ago
Judge: "viewed holistically, Apple’s practice changes undermine the spirit of the injunction" This is not how law works. If Apple complies with the text of the ruling, it's in compliance. You can't hold anyone in conte
646.
by w10-1 2y ago
Given your model, consider publishing a time-to-live metric: if you get no further donations, this is how long the service will last. Then people who care about 1 month, 1 year, or 10 years can decide accordingly. And also describe the proc
647.
by w10-1 2y ago
Hypercard for coding was interesting because it relied on message-passing with a handler hierarchy that introduced modularity questions. Small, accessible and visual languages are interesting for learning to the extent they enable you (your
648.
by w10-1 2y ago
It reduces the code required to convert from N-producers to M-consumer from N x M to N+M because they're reading from and to a well-understood common form.
649.
by w10-1 2y ago
> it makes a lot of assumptions which makes it effectively unusable for other use cases What use-cases are foreclosed and why?
650.
by w10-1 3y ago
> premature infant that weighed a little over 600 grams at birth [...] and is thriving today I'm very glad this turned out so well. Survival rates for infants that premature/small are ~60% (up from basically zero 50 years ago),
651.
by w10-1 3y ago
Yes, law applies rules to facts. No, connecting the facts and rules will not give you the answer. Lawyers are only required when there are real legal issues: boundary cases, procedural defenses, countervailing leverage... But sometimes lega
652.
by w10-1 3y ago
In Shogun, the titular lord chastises his son for still "playing the game of friends and enemies". What if we just stop telling stories, negative or positive? Then perhaps less commenting on commenters commenting on authors writin
653.
by w10-1 3y ago
Investors and owner-occupiers buy for different reasons. Investors are much more sensitive to rates and outlooks. One way to measure investor vs owner impact on prices is speed of sale. While prices are down 3% in SF, house get pending off
654.
by w10-1 3y ago
By "art" some readers think "not methodical" or esoteric/unsharable because the language is denormalized. I think what's meant is closer to Nietzsche saying (post-Kant) that philosophy is justified aestheticall
655.
by w10-1 3y ago
Not correct on safari on macOS. Showing 'Cu' as name for einsteiniem, 'Cr' for copper, etc. (after enabling valence electrons).
656.
by w10-1 3y ago
Every project management tool seems like a subset of features from 1990's project management tools, with the occasional UI innovation supporting collective decisions. It's unclear (from the name and web site) how meegle differs or
657.
by w10-1 3y ago
To avoid strain and accuracy requirements, iOS (and I imagine Android) support Accessibility extensions targeting drag motions - See Accessibility/Touch/AssistiveTouch. It seems fair to have the logical gesture of a drag be provid
658.
by w10-1 3y ago
Leaving aside the tone and accepting the facts at face value, this only shows that Prabhakar was in charge when search failed at Yahoo and then at Google. Business and technical decisions are often made by incompetent people with adverse in
659.
by w10-1 3y ago
Have you shared your checklist anywhere?
660.
by w10-1 3y ago
If hardware manufacturers actually wanted this, Meta would be announcing a licensing deal. This is a threat to Apple: if Apple doesn't relent on advertising/privacy in VisionOS, then Meta will do to VR what Google did for smartpho

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