vikramkr

67 ms·

871.
by vikramkr 6y ago
Based on the responses in this thread, you're not alone. It's not often that a series of arguments is so thoroughly undermined by just one spectacularly bad one, but that's really the comment that's been driving all the
872.
by vikramkr 6y ago
Ramen profitable does not mean the company isn't worth a billion dollars. People aren't suggesting that your endgoal is to be ramen profitable - the mindset is to get ramen profitable as fast as possible so you have a foundation t
873.
by vikramkr 6y ago
That's the second third and fourth accelerators fault. If this is their third accelerator app and they haven't done anything useful with the money they were given initially, then YC should reject them. They shouldn't make it
874.
by vikramkr 6y ago
This is about YC as an investor. If you've got a profitable startup in you, they want you to start it. Lowering the risk gets them more founders and makes them more money.
875.
by vikramkr 6y ago
According to the thread it's not supposed to be enough. You're supposed to go deep into credit card debt because that's how you know you're a Real Founder(tm). You know, if you're privileged enough to have limits hi
876.
by vikramkr 6y ago
At that point you've got enough wealth built up that if you've played things right you have a part time job managing your own portfolio. And a lot of people on that route that I've met have vague ideas of doing charity work o
877.
by vikramkr 6y ago
A smaller check size hurts startups in capital intensive industries. Others already made excellent points about the diversity if founders that can be attracted with a smaller check size, since less money favors people with money already in
878.
by vikramkr 6y ago
I dont think you can make money by sharing information to individuals in that sort of way today. There are people that manage to do it (self help books and all) but I dont think people will pay for online content. I can think of 3 ways that
879.
by vikramkr 6y ago
Triple therapy is what a relative of mine underwent after getting Gleeson score 9 (bad but not metastasized) prostrate cancer. He hadn't been doing regulator screenings or would have caught it earlier. The triple therapy (radiation + h
880.
by vikramkr 6y ago
They considered doing that to reuse the Saturn V with a giant helicopter with rockets at the end of each propeller. It didnt go anywhere. Though people have been using air capture for more reasonable use cases, and rocket lab is going to b
881.
by vikramkr 6y ago
That's what they already do. It's a steerable parafoil. How would they be expected to get the ship lined up underneath the parafoil in time to catch it otherwise?
882.
by vikramkr 6y ago
Forget immersion- just contacting salt water is enough to wreck your day. It's highly corrosive and protecting from that corrosion would require engineering coatings that are light, cheap, and also able to handle the temperature and pr
883.
by vikramkr 6y ago
An area of research I've heard a bit about for next gen e-paper displays is to use electrowetting[1] which is a different approach that looks intersting [1] https://en.wikipedia.org/wiki/Electrowetting#Applications
884.
by vikramkr 6y ago
Thanks for the link. Looks like they've been hugged to death at the moment.
885.
by vikramkr 6y ago
For point 4, that could be a pretty smart move on their part and the reason they're able to keep going. Selling directly to consumers/setting up the distribution and marketing for that etc would be really difficult and a lot of D2
886.
by vikramkr 6y ago
I tried to search through and figure it out before I posted the comment, figuring if I saw a few examples I'd get it, but I just got more confused. This sounds like a really interesting concept for building a essentially a human knowle
887.
by vikramkr 6y ago
I'm a bit confused by the example nanopublications - they just look like a bunch of code[1] - are these meant to be parsed by human readers? Who are these for and what are people supposed to do with them? [1] example: http:/&#x2F
888.
by vikramkr 6y ago
What does a shortage of coins look like today? Difficulty paying for a parking space or a gumball? Is it just difficulty giving change in a cash transaction? Wouldn't stores have access to banks that arent closed to be able to give cha
889.
by vikramkr 6y ago
That one stood out as not seeming to fit the theme of the list to me. I dont think debian should have been included
890.
by vikramkr 6y ago
They're engineering it to pop on purpose to play into investor psychology. Getting the IPO oversubscribed and getting headlines about first day performance is a great way to get people to keep talking about and investing in your compan
891.
by vikramkr 6y ago
Way more debt + years of residency to let that debt pile on makes earning more in the end irrelevant. And you can only really be financially free in a few specialties that pay you enough. If you become a primary care doctor, you're onl
892.
by vikramkr 6y ago
The attitude I'm seeing in this thread is less victim blaming and more attacking the scammers and frauds that kill people with their unethical behavior through selling quack cures to vulnerable patients. This article mentions the docto
893.
by vikramkr 6y ago
If it was a state actor, they'd definitely want access to elon musk's DMs. He hasn't showed a ton of restraint in social media, and he's the CEO of a rocket company that has done some classified launches. And many of the
894.
by vikramkr 6y ago
You look at how much McKinsey will pay you and look at how much money corporate pays, and it becomes a tough deal to stay in medicine if you're even a bit financially motivated. Schools like NYUs new free med school and adaptations lik
895.
by vikramkr 6y ago
They couldn't deliver on their promises and got tangled up in the 2016 Hillary email/podesta/Russia debacle as well as the Volkswagen diesel scandal and imploded soon after. They just couldn't compete with cheap gasoline
896.
by vikramkr 6y ago
They tried with artemisinin and it was a very notable failure. The science worked but the economics didn't add up. The main reason is because chemical drugs are pretty easy to synthesize (even from plants) and that synthetic bio doesnt
897.
by vikramkr 6y ago
IIRC gasping for air has more to do with blood CO2 which is why hyperventilation is so dangerous - you can run out of oxygen without knowing it.
898.
by vikramkr 6y ago
Yes the higher error ones are used for alignment- and even then too high an error rate in a very repetitive region (especially depending on the error type - misreads vs skipped bases etc) make it too challenging to build a scaffold to align
899.
by vikramkr 6y ago
Blue sheets are no joke. I got to see a glimpse of the info the SEC collects and learn a bit about how they use it. Dont underestimate the SEC on market manipulation. You would not be indistinguishable- it's a trap "novice" m
900.
by vikramkr 6y ago
I dont think you can call pacbio up and coming at this point, but nanopore certainly. And those error rate examples are way way too high - illumina is closer to Q30, which is a 1/1000 error rate[0]. 15% would result in an unusable sequ

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