valec

11 ms·

61.
by valec 3y ago
gonzales v raich is probably one of the more absurd examples of this
62.
by valec 3y ago
you don't know how to read papers then. first read the abstract. then the conclusion/discussion. then the methodology to see if the study was conducted reasonably. papers are made to be read by scientists -- dumbing them down to b
63.
by valec 3y ago
your link is for PTSD, not depression. no studies have come out so far showing MDMA has any effectiveness in depression. the proposed mechanism for PTSD involves serotonin release leading to heightened extinction of fear memory in the hipp
64.
by valec 3y ago
That's not what your comment said at all though. >Neurotoxicity unclear. on the onehand, unpublished studies in gorillas show no lesions. on the other, retroactive studies of heavy polydrug abusers show lesions. not super high-quali
65.
by valec 3y ago
this is not true at all. the dissociative effects only last a few hours. the clinical benefit is because ketamine stimulates neurogenesis in the mPFC and hippocampus, restoring plasticity lost in depressed patients. don't make unsubsta
66.
by valec 4y ago
another technique sometimes used is using Transcranial Magnetic Stimulation to create temporary "virtual lesions" to study how knocking out a particular region affects task peformance
67.
by valec 4y ago
different ligands can bind to the same receptor in different ways and cause different signaling cascades. look up "biased agonism"
68.
by valec 4y ago
>Unrelated but another neurotransmitter fun fact: Serotonin is responsible for your feeling of self-confidence this is so oversimplified as to be completely meaningless
69.
by valec 4y ago
i think you are very mistaken. cocaine and amphetamines both enact their effects primarily by drastically raising dopamine levels in the brain (in particular the striatum in the case of the euphoria they cause). neither of them directly tar
70.
by valec 4y ago
IGF-1 is generally bad for longevity. Exercise is beneficial in spite of spiking IGF-1, not because of
71.
by valec 4y ago
you literally can't be high all the time on psychedelics (at least tryptamine-derived psychedelics) because of how quickly a complete tolerance to their effect forms at the 5ht2a receptors
72.
by valec 4y ago
how would you propose setting up a double-blind trial for a psychedelic?
73.
by valec 4y ago
i think it corresponds most exactly with the desensitization of dendritic autoreceptors
74.
by valec 4y ago
>While not to encourage being antisocial, chess also has very good computer programs to play against even better, with the likes of Lichess and Chess.com there is near instant placement into matches with a similarly skilled human
75.
by valec 4y ago
I may be unusual in this regard but I don't think I can remember a single time that I have fallen asleep "by accident." I've never been able to fall asleep in class, or reading a book, or watching a movie or just lazing
76.
by valec 4y ago
I think calling it a caffeine "addiction" is a bit misleading. Dependence is a more accurate word.
77.
by valec 4y ago
what are your thoughts on wellbutrin and isopropyphenidate? (not combined haha)
78.
by valec 4y ago
I'd be curious about the effectiveness of atypical stimulants such as bromantane in treating ADHD. Unlike methylphenidate or amphetamine, they don't directly inhibit reuptake or induce reverse transport of dopamine but instead upr
79.
by valec 4y ago
i'm sorry but if my only concerns as a shorter man were not reaching things on the shelf my life would be immensely better
80.
by valec 5y ago
>while US States are administrative districts of a single sovereign nation this is false. under a unitary government system that would be true but the US runs under a federalist system. states and the federal government are considered s
81.
by valec 5y ago
the A-10 is actually the perfect "fighter mafia" plane aside from its weight. the fighter mafia basically wanted more maneuverability, cheaper planes and CAS than interdiction bombing. A-10 is all of those except light. they were
82.
by valec 5y ago
honestly the reddit r/fitness faq is pretty good. if you don't mind reading a lot the strongerbyscience guides on squatting, deadlifting and benching are very high quality. in terms of programming: starting strength is ok for begi
83.
by valec 5y ago
> i personally do not want to live in a society in which services that use to be available to readily available are no more cause huge chunks of people aren't working/govt is paying them to do nothing. what it seems like you&#x
84.
by valec 5y ago
Sure on the coast but the Great Lakes-adjacent region should fare pretty well, or at least better than everywhere else.
85.
by valec 5y ago
Siberia recently suffered some of the worst wildfires on the entire planet haha. I think probably the safest would be East Canada as they're cold enough but not as tree-like.
86.
by valec 5y ago
hacker news only cares about free speech when it can be used to dunk on "the left"
87.
by valec 5y ago
glyphosate is safe. on it's own it's not carcinogenic. however, the supporting ingredients and solvents are very carcinogenic.
88.
by valec 5y ago
...or to look at your dick from above then closer up
89.
by valec 5y ago
no, it's not. best estimates (admittedly poor) put the incidence around 1/50,000 for frequent users. considering the potential mental health uses and the extremely low toxicity (i'm not sure anybody has ever overdosed on lsd)
90.
by valec 5y ago
steroids only harm the user though. cheats ruin the game for everyone.

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