sungam

10 ms·

121.
by sungam 9y ago
We do see recurrent point mutations as well as recurrently mutated pathways.
122.
by sungam 9y ago
Interestingly it is exactly this problem I am working on!
123.
by sungam 9y ago
Anyone know if the plan is to provide an API to the consumer for management of personal finances?
124.
by sungam 9y ago
Yes in Vivo confocal microscopy is done by Dermatologists The machine is called vivascope
125.
by sungam 9y ago
likely confocal microscopy
126.
by sungam 9y ago
Hi Dermatologist here These features (ABCD) are very helpful for patients and other doctors in highlighting moles that should be checked. However, dermatologists generally use a dermatoscope (magnified image) to examine the pattern of pigme
127.
by sungam 10y ago
There are now very effective treatments for psoriasis to the point that most patients can be clear or nearly clear of the disease. These range from UVB light therapy to drugs such as methotrexate and ciclosporin and a growing number of mono
128.
by sungam 10y ago
Dermatologist here. Most skin cancer diagnosis is relatively straightforward and if the lesion is suspicious will require a biopsy to establish the subtype of the cancer and plan further treatment. There is no reason why this initial visual
129.
Space firm creates ArcaBoard – a 'real hoverboard'(bbc.com)
3 points by sungam 11y ago|1 comments
130.
by sungam 15y ago
Hi, fellow UK hospital doc so fully understand the frustrations with NHS IT. I suspect problems stem from the fact that purchasing decisions are generally made by individuals (management and senior hospital docs) other than those that use t
131.
by sungam 15y ago
A large fraction of modern drug development is focused on specific biochemical pathways, often identified via the study of rare genetic disorders or genome-wide association studies. For example, patients with Familial hypercholesterolemia,
132.
by sungam 15y ago
Yes, that is correct. Most neurons are post mitotic i.e. the cells do not divide in adult life so the mutation would need to be present early in embryonic development.
133.
by sungam 15y ago
As a physician I doubt this will have much of an impact on the cost of health care. The limiting factor here is not technological but cultural. In the majority of patient encounters a diagnosis has either already been made or is obvious. In
134.
DE Shaw: Molecular dynamics on custom silicon(sciencemag.org)
3 points by sungam 16y ago|0 comments
135.
Implementation of a Javascript DNA sequence editor(seqedit.com)
1 points by sungam 18y ago|0 comments
136.
by sungam 18y ago
Ultimately it comes down to sematics but I think of DNA as source code. DNA is already human-comprehensible. The organisation of genes within the sequence is actually fairly straightforward and probably not that different from how you would
137.
by sungam 18y ago
I disagree. Biology had built complex abstractions, it is just that (outside of specific bioinformatic domains) mathematics has consistently proven not to be the appropriate language for describing complex, messy biological systems. I like
138.
by sungam 18y ago
The problem with SNP-based association is that, for the vast majority of disease-associated SNPs, the relative risk is only increased on the order of a few percent at most. When it comes to predicting the risk of an individual (as opposed t
139.
by sungam 18y ago
Some context: This article was a satirical commentary on the situation in evidence-based medicine where the absence of large double-blind placebo-controlled randomized controlled trials was equated with an absence of efficacy, for example i
140.
by sungam 18y ago
This Cell paper was discussed previously on HN. I commented in detail on the paper in that thread:- http://news.ycombinator.com/item?id=256355
141.
by sungam 18y ago
Cysticercosis (pork tapeworm) can cause marked personality changes in humans when cysts form in the brain. http://en.wikipedia.org/wiki/Cysticercosis
142.
by sungam 18y ago
In this study the authors measured the activity of most of the genes in the worm genome and found that quite a large number change in activity ‘expression’ in old versus young worms. In general, for most genes, the amount of protein produce
143.
by sungam 18y ago
Caloric restriction is the only non-genetic intervention proven to increase maximal lifespan in mammals. However it may well be that the magnitude of this effect in humans is considerably smaller than in lower mammals because the mechanisms
144.
by sungam 19y ago
The limitation of SNP techniques is that the magnitude of association between a particular allele and a disease have turned out to be rather low - in the order of 1-2 times increased risk. This is virtually meaningless on an individual leve
145.
by sungam 19y ago
Leaving aside the doubtful utility of this test you really must provide some information about who is behind this company, what techniques will you use to perform the test? What expertise do you have in molecular diagnostics? How do potenti