sradman

90 ms·

811.
by sradman 6y ago
TLDR; use “isolate” not “strain” to describe genomic differences in viruses Strain implies functional differences. SARS-CoV-2, like it’s Coronavirus cousins, is quite stable. The genomic sequences found on NextStrain.org are a powerful tool
812.
by sradman 6y ago
The Stackoverflow CEO and/or PR team is guilty of what journalists call “burying the lede” but the following quote from the message is quite good in my opinion: > This week, we reduced our global workforce by approximately 15%. Most
813.
by sradman 6y ago
You can either take a 5 minute break every 30 minutes or accumulate them for a maximum of 15 minutes in a 90 minute window. There is no magic; most of the benefit comes from the feedback. Tracking highlights how often you are interrupted an
814.
by sradman 6y ago
Legacy seems to be missing from the comments. Before the advent of Cloud IaaS (Infrastructure as a Service) a very large ecosystem of On-Premise hardware and software flourished. The question needs to be considered in the context of greenfi
815.
by sradman 6y ago
I never heard about the ADRB1 gene before. The expressed protein acts as a receptor for epinephrine and norepinephrine so it sounds like it plays a key role in regulating the sympathetic and parasympathetic nervous systems. It makes sense t
816.
by sradman 6y ago
My killer productivity hack is a combination of three techniques: 1. Pomodoro, 2. GTD (Getting Things Done), and 3. Spaced Repetition Learning. Pomodoro Technique helps timebox tasks in addition to prioritizing them. Both are required to st
817.
by sradman 6y ago
I love these kinds of retrospectives as they give insight into the learning process. We tend to focus on the acquisition of specialized knowledge but there is often a body of shared knowledge, the context you might call it, that we pick up
818.
by sradman 6y ago
> Nothing we could possibly produce comes close to what other teams have already drafted, years ago now. This may be true for B2B content but it seems misplaced at a moment when the world is pivoting to adapt to a novel viral pandemic. E
819.
by sradman 6y ago
> The reason I’ve stuck with the things I have isn’t because of grit, as I might have once believed. It’s because I enjoy doing them. “Enjoyment” is only one way of achieving the focus required to succeed. Frustration and ego (e.g. provi
820.
by sradman 6y ago
Building things involves problem solving. The life sciences often involve problem solving without producing an artifact. I think it is the challenge of solving hard problems that unites both pursuits.
821.
by sradman 6y ago
> The best stuff is always produced by very small, tightly-knit teams... This line hints at both the key problem and the path forward for the disillusioned engineer. Things go sideways when we realize that we are not building “the best s
822.
by sradman 6y ago
The poor man’s single lead ECG is complemented by continuous PPG heart rate data. Being able to combine the data of multiple sensors that are synchronized with a single clock provides new opportunities for monitoring and analysis. HRV data
823.
by sradman 6y ago
I think the “30 second finger ECG sampling” is unique to the Apple Watch. Most modern continuous trackers use optical heart rate (PPG) alone. Garmin includes a red light PPG that is used as a Pulse Oximeter during sleep to measure SpO2 and
824.
by sradman 6y ago
I think the argument is that financial forecasts for startups are equivalent to wearing a business suit; they are both anachronisms that signal our desire to succeed but have no causal relationship to the nuts and bolts of succeeding. I’m o
825.
by sradman 6y ago
This paper rests on the assumption that the observed changes in the SARS-CoV-2 genome correspond to a measurable change in the pathogenesis of the virus. This paper “reveals” no evidence for a measured change in transmissibility. It reveals
826.
by sradman 7y ago
This document is inspired by Conventional Commits but lacks the equivalent Specification section. The point of adding structure to unstructured text is specifying the syntax required to make it machine readable. Maybe I’m missing something.
827.
by sradman 7y ago
One of the only good things to come out of this pandemic is the increased emphasis on S-Curves. Models tend to use the predictive power of exponential curves to estimate the steep part of the S-Curve but these predictions are short term and
828.
by sradman 7y ago
The criticism in the Cory Foy’s post takes two forms: 1. We were prepared, and 2. Preparedness can not overcome the systemic oppression and exploitation built into western capitalist society. I have little patience for the second point whic
829.
by sradman 7y ago
Six spheres of climate: 1. Atmosphere, 2. Biosphere, 3. Hydrosphere, 4. Cryosphere, 5. Lithosphere (tectonic plates), and 6. Solarsphere (Milankovich Cycles). This is a fantastic article that helps fill in the puzzle of glacial termination&
830.
by sradman 7y ago
Daniel Lemire compares std::fill in C++ with memset in C in agreement with Travis Down https://lemire.me/blog/2020/01/20/filling-large-arrays-with-...
831.
by sradman 7y ago
It was a popular book that has many dimensions. The subtitle "An Inquiry Into Values" hints at Pirsig's core thrust: a philosophical exploration of what we call "quality". The title and Zen references made for me, a
832.
by sradman 7y ago
The book "Zen and Now" by Mark Richardson retraces Pirsig's route: http://www.zenandnow.org/ Many people took Pirsig's quip in the forward about the book not being factual about motorcycles too literally
833.
by sradman 7y ago
Agreed, the author did hint at this idea with the statement "SQL databases are readily available if you don’t have access to the dedicated messaging infrastructure. They also have some unique features that turn out useful while working
834.
by sradman 7y ago
Perhaps the title of the article doesn't capture its underlying value. PubSubOnSQL Layers rarely make sense compared to dedicated Pub/Sub systems but the trade-off is acceptable in the three use cases described: 1. When your dedic
835.
by sradman 7y ago
My quick first take is that Tencent Tars combines a Google-like binary message/RPC protocol (alternative to Protocol Buffers and gRPC) with NetflixOSS-like Microservice Registry, Lookup, Load Balancing, and Fault Tolerance tools. A bac
836.
by sradman 7y ago
The search for Ambrose Small was part of the plot of Michael Ondaatje’s novel “In the Skin of a Lion". The main character Patrick is a “searcher” looking for Small. Patrick’s daughter Hana and his close friend Caravaggio are main chara
837.
by sradman 7y ago
I think this raises an important issue; some comments are important and it would be helpful if they stood out as such. I disagree with the idea that since SOME comments are important, therefore, ALL comments should stand out. Others have po
838.
by sradman 8y ago
This is an old post. After doing some quick searches I think this rant was a bit premature. I think the problem boils down to Jekyll _config.yml options that should have been specified in the GitHub instructions. Specifying kramdown is not