spangry

64 ms·

511.
by spangry 10y ago
Yeah I oversimplified protein 'chaperoning' for brevity's sake. As for prion recruitment of other proteins leading to amyloid plaque formation in the brain, I concede it's an open question. But my money would be on &#x27
512.
by spangry 10y ago
I guess you'd have to sustain the argument for group selection in general first. On the individual level, it wouldn't surprise me if the more 'seasonal' variations of depression are an evolved resource conservation strat
513.
by spangry 10y ago
Winston Churchill is another good example of a depressed (or possibly bipolar) leader (Churchill's "black dog"). Interesting that they are both war-time leaders. On Lincoln, the recorded remarks of a fellow Illinois legislato
514.
by spangry 10y ago
I wonder if the concept is similar to what Buddhists call 'equanimity'... EDIT: nope, looks like they had a different word for it: https://en.wikipedia.org/wiki/Equanimity#Stoicism
515.
by spangry 10y ago
No one's really good at it. There's nothing wrong with thinking (or being thoughtful), but there's a difference between choosing to think about something versus reflexively judging, labelling, ruminating etc. Not being th
516.
by spangry 10y ago
I hope I'm not committing some faux pas replying to such an old thread... There are a bunch of hypotheses about why we have yet to encounter or discover other intelligent life in our galaxy/universe (or, more specifically, the Fer
517.
by spangry 10y ago
Yeah I'm not so sure that this could be a sustainable treatment, even if we assume it has some temporary mood-lifting effect. Speaking as someone who's now suffered through a series of major depressive episodes over the past year
518.
by spangry 10y ago
Sorry, damn phone spell check. Yeah I meant PFC.
519.
by spangry 10y ago
That would be an interesting data point. Highly acidic...
520.
by spangry 10y ago
Just to provide the counter-point: also possible that increased protein metabolism and synthesis (the defining feature of ketogenic diets) increases the likely hood of long -lived prions: proteins that fold abnormally, which can be learned
521.
by spangry 10y ago
Damn auto-correct. That should be "acetone respiration".
522.
by spangry 10y ago
I think this is the crux of the issue. If one ascribed to the prion hypothesis, than ketogenic metabolism would almost certainly have to be related to higher probability of prion formation, and more survivable conditions in vivo. Another co
523.
by spangry 10y ago
To be honest, is seems more likely the 'delirium' is actually mild psychosis brought on by excess dopamine in the PDF in particular. Many Parkinson's medicines treat some of the cognitive deficits it can cause with stuff like
524.
by spangry 10y ago
Interesting you mention this, as I've reached a similar (albeit very preliminary) conclusion while researching a medication I've been forced on top by the so-called state govt 'chief health officer'. It has wrecked my li
525.
by spangry 10y ago
Interesting. Might the effect be due to coffee's acidity? When you drink coffee, the environment in your stomach becomes more acidic, which would (just speculating) make it more effective at destroying/metabolising any mal-folded
526.
by spangry 10y ago
I kinda feel like that 'safest' option, even when including the 'no nukes' option, is for stable and rational powers to have lots of nukes, and probably a 'fail-deadly' doomsday machine type setup. If they&#x27
527.
by spangry 10y ago
I can't remember where I got this from, but wasn't this 'instability' strategy also one that Nixon (personally) employed? As in, he deliberately behaved in a way to make the Soviet leadership think he was a bit of a madm
528.
by spangry 10y ago
Wow, now I really want to know what's in one of those letters. Apparently the British PM is presented with 4 possible options, according to that wiki page: 'The Guardian reported in 2016 that the options are said to include: &quot
529.
by spangry 10y ago
Is it an unstable solution? Are we assuming full rationality here, or is this the 'crazy commander' type scenario? Strangely, I can't help but think the situation becomes more stable if both sides actually have 'doomsd
530.
by spangry 10y ago
As someone who works in government, you're dead right about incompetence, and I would add 'ignorance'. These are the two things I have seen do the most harm, by an extremely large margin. And I think it's inexcusable. I&
531.
by spangry 10y ago
The thing I sometimes have trouble with is: 1. Corporations behave like sociopaths. 2. Corporations don't really exist. They're a legal fiction that, in reality, is just a group of people working towards a common goal (maximum pro
532.
by spangry 10y ago
Ok, fair enough. I would agree with the view that using md5, presumably for the faster performance, is probably not the best trade-off to be making here. Unless we're dealing with an NVMe drive (or something more exotic), you're l
533.
by spangry 10y ago
I'm not trying to justify anything. I'm just trying to suggest you're labouring under a misapprehension. And this has nothing to do with security. I'm guessing you've heard the (good) advice that md5 is not a secure
534.
by spangry 10y ago
Using md5 is only a problem here if someone has actually gained access to your files and then gone to the trouble of secretly adding new files and calculating/brute-forcing the correct 'chosen-prefixes' to ensure a clash. It
535.
by spangry 10y ago
Seems like a worthwhile initiative (and it appears that Mozilla agrees). A suggestion: perhaps it would be worth focusing on the Python standard library, at least initially? I find the 'narrative style' and the code examples in th
536.
by spangry 10y ago
Thank god I'm not the only one. I keep hearing about how opaque AWS pricing is compared to GCP, yet I personally cannot make any sense of google's pricing. It's difficult to explain, but I struggle ti figure out how much I&#x
537.
by spangry 10y ago
This approach works well for me (when I have the motivation to write the list). Breaking each task down into smaller sub-tasks is helpful too. I usually end up with a list of very simple directives that leave little room for thinking (or ru
538.
by spangry 10y ago
This is a good observation, and supported by even a casual glance at international macro over the past 35 years. "Hot money" flows very quickly in countries with deregulated captial markets.
539.
by spangry 10y ago
This would be great tax policy. Unfortunately the 'conventional wisdom' among the leadership caste in my country (Australia) is that this would be political suicide. Pretty much every Prime Minister for the last 15 years has repea
540.
by spangry 10y ago
Also selenium grid docker containers. Unfortunately their Python documentation isn't the best (though there's some excellent third-party created Python documentation available). To save you the head-scratching I went through, it&#

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