sinenomine

32 ms·

1. 301.▲
   by sinenomine 5y ago

   Judging by sparse centenarian studies, transthyretin amyloidosis seems to be a factor limiting human lifespan to ~120 years: https://www.fightaging.org/archives/2019/07/the-question-of-... Current understandi
2. 302.▲
   by sinenomine 6y ago

   I have a fair amount of acquaintances who came to realize it is possible to do something about aging, not just sit and wait. Some of these fear death, many not, for those it's just a principled position they assume. Maybe it's a g
3. 303.▲
   by sinenomine 6y ago

   Don't mean to offend, but I find it a remarkable collection of acceptable platitudes on the topic. Yes, death exists. No, it's not something to be in awe of, something to appreciate like a beautiful tree. Time arrow points in the
4. 304.▲
   by sinenomine 6y ago

   I agree about growing weary about life is a noticeable trend, among the older relatives I know. Still, human beings are remarkably different. Some are driven by a single overwhelming emotion, like curiosity. To these, I can relate. Observin
5. 305.▲
   by sinenomine 6y ago

   I also like this related illustrative video about our attitudes to aging and longevity https://www.youtube.com/watch?v=GoJsr4IwCm4
6. 306.▲
   by sinenomine 6y ago

   This is over-dramatizing. For many people, life is obviously a valuable enough experience to be extended many times over.
7. 307.▲
   by sinenomine 6y ago

   Thank you for posting this paper, it is more statistically/psychometrically sound than the one I posted. By testing each person across a significant path of their lifespan, and correcting for test-retest drift, it produces a more defen
8. 308.▲
   by sinenomine 6y ago

   Another interesting fact about metformin: it increases lifespan and healthspan in lab mice [1] 1. https://www.nature.com/articles/ncomms3192.pdf
9. 309.▲
   by sinenomine 6y ago

   I'm in my late 20's and I notice my mental energy/sharpness being slightly lower compared to what they were at my peak age of 22. I learned to compensate for this with some behavioral and biochemical kludges, but the reality
10. 310.▲
    by sinenomine 6y ago

    This is an article written by a journalist. If we want to get to the bottom of things, we can open Google Scholar and search for related peer-reviewed publications, finding [1][2] in the process. What do we see in [1] and [2]? A very promin
11. 311.▲
    by sinenomine 6y ago

    This time there are several treatments that extend life [1] in a small laboratory mammal - mouse, sometimes by double digit percentages: >The NIA Interventions Testing Program (ITP) has to date reported on four drugs with consistent majo
12. 312.▲
    by sinenomine 6y ago

    These are not jobs but positions of power; the assumption that success in securing them is indication of merit in the sense of producing best outcomes for society at large, or even this specific firm or department in isolation, amounts to j
13. 313.▲
    by sinenomine 6y ago

    There is a well known fact in the field of psychometrics: human general intelligence g can be modeled as two relatively independent sub-factors: verbal intelligence and spatial intelligence. Other sub-factors, if any, are way more specula
14. 314.▲
    by sinenomine 6y ago

    > Well, would you mind giving us all a hint here? I'm curious. Given IQ like many other human traits can be modeled as GxE, one can optimize the "E" part, which boils down to avoiding ruining the realization of genetic pot
15. 315.▲
    by sinenomine 6y ago

    Thank you for kind words. This is hard won advice, I hope it will be of some use. Looking back it's frightening how fast our life comes and goes, with two decades of learning just to become prepared for two decades of peak adulthood, t
16. 316.▲
    by sinenomine 6y ago

    Let me disagree politely from a similar background, though from another side of the globe. I rarely write on HN, but I think this is important for others who may read it. As someone who grew up lower-middle class, who read HN for ~10 years
17. 317.▲
    by sinenomine 6y ago

    One can use this to express a large part of a deep ML model as a reversible function, thus drastically lowering memory requirements for backpropagation. The same technique, but applied by hand was recently used to speed up training for tran
18. 318.▲
    by sinenomine 6y ago

    I think your first sentence is an answer to every thread of this nature. The rarity of this sentiment and people's sentiment towards it are self-evident. Training a language model similar to GPT-3 in capability, but cheaper (and smalle