siganakis

12 ms·

61.
by siganakis 14y ago
Most of these points rely on the belief that evolution is always made up of slow, small changes in the genetic code. While this is the case most of the time (and enables the fine tuning that we see in many species), evolution can happen
62.
by siganakis 14y ago
I think that you have confused mutation with gene in your initial assertion. There is probably only a few percent of variation between all of your 2^100 ancestors genomes (the majority of whom will be related), so protein coding regions of
63.
by siganakis 14y ago
Isn't RNASeq more like looking at really verbose log messages? Where you only sample 1% of the log messages and may be looking for an event that happens 0.01% of the time?
64.
by siganakis 14y ago
Hello, I was in a similar position the year before last. Essentially I was well paid, but realized that my career was either going to go into management, or had reached a plateau. Basically, much of the challenge of programming had been l
65.
by siganakis 14y ago
Thanks for your comment. My email is terence (at) siganakis [dot] com if you would like to chat. The R integration stuff is more for the data science crowd. I feel it would be useful to have a streamlined way of writing a query to return
66.
Ask HN: Interest in a new open source, fast, in-memory, data analysis system?
4 points by siganakis 14y ago|3 comments
67.
Simple recipes for predictive analysis of big data in R (KNN, GLM, SVM & CT)(siganakis.com)
2 points by siganakis 14y ago|0 comments
68.
It's Time to Bet on Genomics(forbes.com)
2 points by siganakis 14y ago|0 comments
69.
by siganakis 14y ago
I think that there is a feeling in the community among many people that all genetic information should be freely available, which at this stage I feel is wrong. When people go to a doctor, they expect answers, and the reality is that in ma
70.
The moral and ethical complexity of genetic research(bloomberg.com)
2 points by siganakis 14y ago|1 comments
71.
by siganakis 14y ago
I too have spent quite a few years working in this area. I have primarily been involved in building tools to make this kind of analysis easier - but it is very difficult. As you mention, the primary issue is that almost all business data i
72.
by siganakis 14y ago
From the pledge section: $50 gets you access in May 2013 $100 gets you access in December 2012 $200 gets you access in October 2012 $500 gets you access in August 2012 $1000+ gets you access in May
73.
by siganakis 14y ago
So the product will be open source, but you need a license to download it? So its open source, but not "free". Are there any well known licenses that support this? I take it that it also means that the license will not allow for you to co
74.
by siganakis 15y ago
Cancer survival rates are a mixed bag with many barely moving at all. The statistics below are based on that for Victoria, Australia (population of about 5.5m). 5 year survival rates for the following cancers has barely changed at all sinc
75.
by siganakis 15y ago
The trouble is that there are many, many different ways that a cancerous cell is able to be cancerous. A malignant cancer cell has generally had upwards of 7 mutational events that directly enable it to replicate itself enough times to form
76.
How the iPad 3 could take touch screens to the next level(techyinzer.com)
2 points by siganakis 15y ago|0 comments
77.
by siganakis 15y ago
Bitmaps are very good at "Seek" operations (where I try to find a value), but poor at "Access" (where I try to find the value at an index). This is because "Access" requires that I check all the bitmaps to see which one has the set value.
78.
by siganakis 15y ago
My bad, I got that wrong. The translated array should be: 1 0 2 3 0 3. I am correcting the article now. For a non-rushed, accurate description please look at: http://www.alexbowe.com/wavelet-trees Edit: Got it wrong again... I guess this
79.
by siganakis 15y ago
Thank you, this is exactly why I wrote the article - knew I was missing something! I'll do a follow up with the rank / select optimizations. Thanks!
80.
by siganakis 15y ago
What we have is 32 bit integers (or anything really) that we store using bit vectors (which are implemented as 64 bit integers). These structures are read only. I believe that there is some work on making updatable Wavelet trees but I think
81.
Building data structures that are smaller than an array and faster (in C)(siganakis.com)
134 points by siganakis 15y ago|34 comments
82.
by siganakis 15y ago
Just to pick you up on one thing, we have sequenced thousands upon thousands of genomes since the human genome project finished. For example there is the 1000 genomes project [1], and a project I am working on is sequencing about 100 ovaria
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Harvard Mapping My DNA Turns Scary as Threatening Gene Emerges(bloomberg.com)
4 points by siganakis 15y ago|1 comments
84.
The NASA breakthrough that could save millions of lives(gizmodo.com.au)
4 points by siganakis 15y ago|0 comments
85.
by siganakis 15y ago
Does that mean that if I have 2 workers that I can be certain that they are on different logical machines in the event of a machine failure? Or may my 2 workers actually be on the same machine?
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The Top Worst Things About Working in a Lab(sciencecareers.sciencemag.org)
2 points by siganakis 15y ago|0 comments
87.
by siganakis 15y ago
I have been using AppHarbor for the past few months and have been very impressed. The new pricing seems reasonable, but I would like to know exactly what a "worker" is (e.g. is it a worker process, a thread, or a server?). All in all, its p
88.
by siganakis 15y ago
I would be very interested in hearing more about that project, as it sounds very similar to what I am working on for my cancer research. The two problems I keep running into are that run length encoding means you have to read the entirety o
89.
by siganakis 15y ago
Yes but each additional index adds to the storage requirement of the data. With column oriented designs each column is often indexed with bitmap indexes which are very small (often the index + raw data is smaller than the raw data stored in
90.
by siganakis 15y ago
It is also worth noting that some of the technology underpinning FastBit is actually patented (the Word Aligned Hybrid method of run length encoding). http://www.freepatentsonline.com/6831575.html Basically the patent covers the method of

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