Y
HN Search
Hacker News Search
new
|
comments
|
top
|
jobs
robbiep
searching PlanetScale…
1.
▲
2.
▲
3.
▲
4.
▲
5.
▲
6.
▲
179 ms
·
1681.
▲
by
robbiep
14y ago
Your post kind of suggests that this was the first major company to ever be overcapitalised and incorrectly valued. This is patently not the case. The people that bought into the FB IPO did so out of their own free will. That they believed
1682.
▲
by
robbiep
14y ago
Si. I really think the role of history here is important- there is nothing new or especially important about the current burst of innovation, or as Joseph Shumpeter termed it, creative destruction. We are just in another phase of human and
1683.
▲
by
robbiep
14y ago
No h1srf I don't know anything about merrill shorting it, I was responding to wkasel's assertion in the second post of this thread that they did so. I have done no research regarding shorting on fb in this period. However Morgans would have
1684.
▲
by
robbiep
14y ago
This is not a new phenomenon though. Look at tech bubble #1. hell, go back in time and look at Tulip Mania or the railroad bubble in the late 19th century. Wall Street will continue to do what is in it's interest. With average returns from
1685.
▲
by
robbiep
14y ago
I agree with your point about every techcrunch etc saying what 'facebook NEEDS to do' - as if you can judge the failure/success of a company 3 months post IPO on the value of a stock. I continue to disagree with you about this fucking Zucke
1686.
▲
by
robbiep
14y ago
You are right. Brainfart. thanks
1687.
▲
by
robbiep
14y ago
I feel like this article misses a number of points. Firstly, the modern IPO is chiefly about giving early investors and staff an exit ticket. It is therefore in their interests to price it as high as possible. The fact that there was signif
1688.
▲
by
robbiep
14y ago
It's a biochemistry term. Any first year biochem textbook will contain the information you want, would be happy to post Dropbox to my notes if you are interested
1689.
▲
by
robbiep
14y ago
Biochemically speaking, ketosis is starvation. Once you exhaust your livers supply of glycogen (within 24 hrs usually) you begin the metabolic changes to gear up to burn muscle for ketogenesis. This involves secretion of enzymes that will b
1690.
▲
by
robbiep
14y ago
Aah the pinger diet strikes again
1691.
▲
by
robbiep
14y ago
Our body doesn't posess the enzymes to dehydrate saturated fats, therefore we can't process them as efficiently, Additionally saturated fats lead to cell membrane instability and 'crystallisation' due to the straight-line chemical arrangem
1692.
▲
by
robbiep
14y ago
I agree with this. Loved first season. However, part of watching a great series (Any series, or production, or stage show, or whatever) is that you must believe the myth that they are feeding you... 'Suspend disbelief' in order to become to
1693.
▲
by
robbiep
14y ago
that depends. Cheapest to get there? Because a cup of coffee there will set you back more than in sydney these days
1694.
▲
by
robbiep
14y ago
refurb is right - we essentially do this now, our limitations are: - Cost of sequencing - Toxicity of current drugs in combination - lack of suitable drugs - lack of patient trials More on the last: This is on which everything depends. Med
1695.
▲
by
robbiep
14y ago
yes - sort of - that's what the paper is about essentially - it details a gene therapy approach where T cells are removed, taught how to recognise surface antigens for leukaemia cells and re-injected into the body, leading in 3 weeks to a c
1696.
▲
by
robbiep
14y ago
be cautiously optimistic. It's real research that has worked in animal models. It remains to be seen whether it will be as effective in humans. Additionally, shrinking a tumour is a long way from a cure. For example - The drug Ipilimumab (m
1697.
▲
by
robbiep
14y ago
Brain cancers mostly disrupt the blood brain barrier, Which is an organised tissue structure that exists to preserve the microenvironment of the brain against normal fluctuations and insults. Cancer is disorganised tissue that doesn't know
1698.
▲
by
robbiep
14y ago
I don't think there is any great mystery there - mutation and copy errors create the initial conditions that lead to loss of function of tumor supressor genes or in of function in oncogenes, caused by known risk factors and some unknown ris
1699.
▲
by
robbiep
15y ago
Hi kens, This is actually not powered by electricity but by the gradient of hydrogen ions between the inside and outside of the mitochondrial matrix... As jballanc says, and you say, this is awesomely cool though. I use this video http://