rleigh

11 ms·

61.
by rleigh 4y ago
The high clock speed and multiple cores are great. It's definitely a beefy system. But this is completely orthogonal to timing accuracy and consistency. Speed does not make it more consistent. Tiny low power MCUs have much more acc
62.
by rleigh 4y ago
No, the consistency of the timing is terrible on Linux. Seriously, stick a scope or logic analyser on e.g. an I2C line and look at the timing consistency. Even on specialised kernels for realtime use, you can have variable timing delays be
63.
by rleigh 4y ago
It's still an A-profile MPU and not an R- or M-profile MCU, and while it will be fast it will have less deterministic behaviour than we might like. If you disable the caches and MMU you'll get better consistency. But wouldn&#x27
64.
by rleigh 4y ago
You're missing the point. "Nobody bothered to update it" is key. It's not being proactively maintained, and as a result it's looking to the past, and ignoring the present. And it's not just about this one sp
65.
by rleigh 4y ago
The autotools deserve their share of criticism here. They should be solving the portability problems of the present day, but they are still stuck in the past solving the portability problems of the 1990s. Still catering for pre-C89 compile
66.
by rleigh 4y ago
Because they are temperature-controlled and contain a refrigeration unit. In biological and medical applications, you might want to have the samples kept cool for stability. You'll transfer them from a fridge or on ice into the cooled
67.
by rleigh 4y ago
I don't think it's me spreading baseless misinformation, it's you . Take a long hard look at what you wrote, what I wrote, and then think critically about the problem from all of the angles. I have a degree in Molecular Bio
68.
by rleigh 4y ago
The Autotools do have dependencies: they require a functional Unix platform to run, including a shell and a fair number of common command-line tools. This is the number one reason people use CMake. It's a single binary that runs on e
69.
by rleigh 4y ago
The reason for the recent stability is that the Autotools have been essentially unmaintained for the past 15 years. When there were steady releases back in the early 2000s, we experienced regular incompatibilities and breakage. Today, the
70.
by rleigh 4y ago
Forget the government. Do we have transparent and trustworthy lab staff? After working in a BSL3 lab, I've seen some fairly poor working practices including someone infecting themselves, presumably due to sloppy working practices. Th
71.
by rleigh 4y ago
What do you exactly mean that Gain of Function is "easier said than done"? We routinely engineer changes in viruses for all sorts of purposes. Even I can do it [baculovirus expression cassette vectors--takes less than a day from
72.
by rleigh 4y ago
Currently just starting with a very simple prototype, which is a very basic action scheduler for running analysis workflows. It will become more capable as more system functionality is wrapped and exposed. That ease of wrapping and sandbo
73.
by rleigh 4y ago
In vitro medical diagnostics, using microfluidics, fluorescence spectroscopy and imaging.
74.
by rleigh 4y ago
Many thanks for the reference, this looks like a really interesting device, and it has quite a lot of similarities with the type of system I'm working on (albeit in a completely different application domain).
75.
by rleigh 4y ago
Have you tried sol2? It's vastly more capable and transparent. It's also 100% native C++ code, so is just part of your application, with no extra tooling required.
76.
by rleigh 4y ago
Out of interest, is there any public information about your project? I am currently prototyping a Lua environment for instrument control in a regulated environment. I've added several customisations and safety mitigations to make it su
77.
by rleigh 4y ago
> As someone who spent 12 years of my life in academia (postsecondary, university life), this is nothing like the “culture in academia” I know. This isn't something that just happened overnight. I studied and worked in academia for
78.
by rleigh 4y ago
I'm a regular city cyclist. Most of the time, you won't need a helmet. But on the very low number of occasions you do need one, they will save your life. It's worth wearing one just for these occasions. I've come off
79.
by rleigh 4y ago
I'd much prefer a compromise, like the FreeBSD quarterly updates vs daily, so you can pick the update frequency. I can't tell you the total number of wasted hours my previous organisation spent upon maintaining MacOS infrastructur
80.
by rleigh 4y ago
The whole field! This was actually a thing(!)
81.
by rleigh 4y ago
I've still got my 3rd edition copy (from 1999 when I was an undergrad molecular biologist). Most of the basic biochemistry and molecular biology will be exactly the same--it hasn't changed much if at all. While there have been l
82.
by rleigh 4y ago
Are you really, really serious? Academia is a hugely elitist pyramid with well-demarcated layers, and the lab technicians are at the very lowest level of the pecking order, down with the cleaning staff. They might be "needed", but
83.
by rleigh 4y ago
There might me an opportunity for a company to enter this space, but then again maybe not. When everything is a mess of ad hoc Perl, Python and R scripts to solve unique one-off problems, you might well find that there isn't a sufficie
84.
by rleigh 4y ago
> you're working towards the betterment of humanity If only this was actually true. In reality, you're being taken advantage of and it's very manipulative and deceptive to make this claim.
85.
by rleigh 4y ago
Principal Investigators. Basically, the academics who get the grant funding and run their own research groups.
86.
by rleigh 4y ago
How are we "as a community" going to be able to improve this? It's ultimately down to the cultural norms of the field, as well as the realities of academic funding. I was a research software engineer (RSE) for the best part o
87.
by rleigh 4y ago
> I’m more productive in it than with “modern” tools. Are you objectively more productive, or do you perceive yourself to be more productive? I was an Emacs diehard for nearly two decades. Then I got introduced to CLion. In retrospect,
88.
by rleigh 4y ago
It's not "nothing". When you have to pay that per team member, it adds up to a vast sum very quickly. Especially when you're required to pay that for everyone using GitLab, even just to use issues or download build art
89.
by rleigh 4y ago
It is not possible to be certain of this. You can't state that as an incontrovertible fact. Is it beyond reasonable doubt that a virus created as part of a gain-of-function research programme escaped? We simply don't know defini
90.
by rleigh 4y ago
Others have mentioned QNX. There is also ThreadX, which is a "picokernel". Both are certified for use in safety-critical domains. There are other options as well. Segger do one, for example, and there's also SafeRTOS, and

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