pcrh

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181.
by pcrh 1y ago
"Rationalists" do seem to have a fetish for ranking people and groups of people. Oddly enough, they frequently use poorly performed studies and under-powered data to reach their conclusions about genetics and IQ especially.
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by pcrh 1y ago
This is why experimental science is different from observational studies. Statistical analyses provide a reason to believe one hypothesis over another, but any scientist will extend that with an experimental approach. Most of the examples g
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by pcrh 1y ago
Very impressive video! Such sprites must have been seen at that altitude often enough in history, and as they're quite distinct from lightening I wonder if there is an historical record of them?
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by pcrh 1y ago
This is a history Chinese keyboards before word processors, and even as they were first introduced: https://spectrum.ieee.org/chinese-keyboard Very interesting! It was certainly a different technological challenge... Also d
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by pcrh 1y ago
The question I was addressing was whether the NIBR was more or less economically efficient than a more free-wheeling culture of start-ups failing or succeeding, with the successes transitioning either to "Big Pharma", or becoming
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by pcrh 1y ago
This is the part that gets me intrigued. It's quite difficult to parse, having so many conditionals... ifs, mays, woulds, "subject to further challenge", etc It doesn't seem (to me) as definitive as some claim. Hopefull
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by pcrh 1y ago
Wow! That's a great option for browsing CNN!
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by pcrh 1y ago
For an individual VC firm that may be the case, but perhaps not for the whole drug discovery sector?
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by pcrh 1y ago
I was referring to start-ups that are not acquired. For example a VC may fund a range of biotech companies, but only recoup on those that are acquired. Equally there are many examples of drug-based biotech that simply fail for a range of re
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by pcrh 1y ago
This analysis appears to propose that buying-in drug development programs is more financially efficient than developing them in-house. Presumably these bought-in programs are found among smaller biotech companies. This overview however omit
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by pcrh 1y ago
The question here is why names are so highly predictive. It seems highly unlikely that each generation would be selecting on precisely the same genetic features of a particularly prominent family name. This is because that which provides
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by pcrh 1y ago
> a lot of people on the street right now are happy enough living on the street. This must be one of the most brain-dead things I've read on this site. It's "not even wrong".
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by pcrh 1y ago
Wouldn't assortative mating that is sufficiently strong to overcome the 50% dilution per generation amount to consanguinous mating?
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by pcrh 1y ago
>they map the first two principal components of a bunch of humans and get a map of Europe Interesting! Can you provide a link to this paper?
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by pcrh 1y ago
Family names are not as strongly correlated with genetics as you might be assuming. Consider that for each generation the genetics of the family founder are diluted by 50% (assuming that consanguineous relations are excluded). So after 5 ge
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by pcrh 1y ago
Having quickly scanned the paper.... it does not appear to have studied social class, but educational attainment and geographic mobility. Further, for the genetic correlation with educational attainment r^2=0.06 (Fig. 2) which is perhaps
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by pcrh 1y ago
This paints a depressing picture, which also has some support in empirical evidence. However, democracy is not as feeble as this analysis would suggest. After all, we can see that major shifts in political support for policy positions are p
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by pcrh 1y ago
This is in line with another quip about AI: You need to know more than the LLM in order to gain any benefit from it.
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by pcrh 1y ago
Unfortunately this review does not really provide any detail on the author's ideas. He did however publish a review 10 years ago [0] (a link to a free copy can be found on Google Scholar). There he comprehensively addresses the limitat
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by pcrh 1y ago
On the other hand, elected politicians (senators, MPs, etc) are supposed to represent what the populus wants, else be ejected. So in theory, they should be paying as much heed to lobbyists as to their constituents. The question arises, then
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by pcrh 1y ago
To clarify, reporting requirements for private companies are minimal below a certain level of revenue. Once that level is passed, they need to file. Google withheld how well its advertising was doing until that threshold was crossed, and it
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by pcrh 1y ago
Interesting perspective. I was in SF at the time, and remember Ask Jeeves, Inktomi, Alta Vista, Yahoo, etc. Google's attraction at the time was not necessarily that it found you the best site for the information you sought, but that it
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by pcrh 1y ago
Re-phrasing to fit within word or character limits is certainly something I would pay for! I have often spent more time doing this than writing the original draft, especially for grant applications...
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by pcrh 1y ago
I am experienced in writing scientific papers, so I know what it takes. I remain to be convinced that the tasks you propose an LLM could do contribute any more to the process of writing a paper than dictating to a typist could do in the 195
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by pcrh 1y ago
>"here are the overarching implications and important results". That's the outline. I doubt an LLM would help much in deciding how best to present the finer details, as they will be very specific to your particular manuscr
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by pcrh 1y ago
A researcher on any particular topic is not supposed to be an "average" researcher, but already deeply familiar with their subject.
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by pcrh 1y ago
Any researcher already has this in their head long before any writing takes place.
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by pcrh 1y ago
I am quite puzzled how an LLM could even start "write" a scientific paper. Say you start with a set of findings, for example, western blots, data from a transgenic mouse engineered for the relevant gene, and some single cell seque
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by pcrh 1y ago
Quite. "PhD-level knowledge" is the introduction to one's PhD thesis. The point of doing a PhD is to extend knowledge beyond what is already known, i.e that which cannot be known by an LLM.
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by pcrh 1y ago
Very interesting, thanks! I am also curious about the relative popularity of typography on HN... it seems to gain the interest of HN readers more than most other forms of design or art....?

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