pcrh

5 ms·

61.
by pcrh 5mo ago
Sleep-like states exist in animals with nervous systems with a complexity above that found in flatworms, even snails sleep. Sleep therefore appears to be an essential characteristic of more complex biological nervous systems, i.e. biologica
62.
by pcrh 5mo ago
The function of sleep in animals is largely obscure. One thing we do know for certain is that it is necessary, it is needed in "dumb" animals as well as in you and I. If an animal can't sleep it will eventually die. I don&#x2
63.
by pcrh 5mo ago
I can't pretend to understand how LLMs work, but I can be sure that anthropomorphizing their functions is not helpful to an objective debate over their abilities. Does a motor vehicle get "sleep" when it is serviced? When I r
64.
by pcrh 5mo ago
Mostly by requiring analysis and synthesis rather than memorization. It's been some years for me so things might have changed, but no tech was allowed into the exam rooms, except for calculators in some subjects. Everything was done by
65.
The Latest News in Vaccine Obstruction(science.org)
30 points by pcrh 5mo ago|0 comments
66.
by pcrh 5mo ago
With reference to the "cultural" allusions of many posts in this thread, I can assure you that in the WASP UK universities of Oxford and Cambridge, all exams are "proctored". It is assumed that students will attempt to c
67.
by pcrh 5mo ago
Incomes in the former GDR are comparable to those of Poland. They still lag behind West Germany, however (as does Poland).
68.
by pcrh 5mo ago
The questionnaire included 200 food items. Within the study, 9 food categories are listed. No adjustment for multiple hypothesis testing is reported in the methods section. We have to take it on faith that they did in fact specifically set
69.
by pcrh 5mo ago
The source of funding is not the only suspicious thing... From the actual study, which is free to read [0]: >Dietary intake was assessed at baseline using a validated, self-administered FFQ that included >200 food items So out of 200
70.
by pcrh 5mo ago
The San Joaqin Valley picture is astounding! https://www.usgs.gov/media/images/land-subsidence-san-joaqui...
71.
by pcrh 5mo ago
Those are impressive! It's worth noting that the photographic technology had advanced considerably between 1848 and 1906. The exposure time of these kite photographs must have been quite short, given the obvious instability of the plat
72.
by pcrh 5mo ago
The amount of subsidence is quite dramatic, up to 25 cm per year! What are the practical consequences of this today, and what is being done to remedy this?
73.
by pcrh 6mo ago
Both meta-analyses above cover all eligible clinical trials for the respective strategies, targeting the GLP-1 receptor, or targeting amyloid. For the GLP-1 strategy, Table 1 in the above paper shows that all drugs were clearly effective.
74.
by pcrh 6mo ago
If you grouped all GLP-1 agonists that had entered clinical trials, they would be shown as successful [0]. No GLP-1 receptor agonist has failed to reduce appetite in clinical trials, but some were better than others. The point about the ant
75.
by pcrh 6mo ago
All the trials included in the Cochrane review demonstrated removal of Aβ amyloid from the brain. Side effects were relatively modest, except for edema and micro-bleeds. So they are all legitimate tests of the hypothesis that removing Aβ am
76.
by pcrh 6mo ago
The first GLP-1 receptor agonist to enter clinical trials was exenatide by Amylin Pharmaceuticals. It worked from the get go.
77.
by pcrh 6mo ago
The Cochrane review did not ask the question of whether Lecanemab (for example) worked, it asked the more general question of whether targeting amyloid worked. If targeting amyloid, generally, worked you might expect all approaches to targe
78.
by pcrh 6mo ago
The question asked in the Cochrane review linked to above is whether there is evidence that current treatments targeting amyloid provide relief. Their conclusion is that the effect is too small to be considered beneficial. Especially whe
79.
by pcrh 6mo ago
Agreed, using these anti-amyloid treatments at an early stage in people with a high risk of early onset Alzheimer's disease, such as those with Down's syndrome, is likely the most robust test available of the theory that Aβ amyloi
80.
by pcrh 6mo ago
The point of systematic reviews is to be un-biased. So if their question is whether targeting Aβ amyloid is a valid approach they have to include the unsuccessful trails as well as those purported to be successful. As to the trials specific
81.
by pcrh 6mo ago
Unfortunately the evidence that targeting amyloid (e.g. Lecanemab and Donanemab) improves the symptoms of Alzheimer's disease is very weak. See the latest systematic review [0]. This does not mean however that amyloid plays no role i
82.
by pcrh 6mo ago
Unable to read the full article, however the amyloid hypothesis is not without solid scientific foundations. Alzheimer's disease may occur either due to inherited mutations in the genes for APP or presenilin, in which case it can occur
83.
by pcrh 6mo ago
All Souls College doesn't have any students, graduate or otherwise. It's primarily a place where people can conduct research into any topic, most often in the humanities. It frequently hosts journalists, politicians, lawyers, etc,
84.
by pcrh 6mo ago
It's still a problem in 2206?
85.
by pcrh 6mo ago
It's missing the characteristic element of a periodic table, which is both a visual and explanatory representation of the relationship between the composition of the different substances and their properties. The concept is there, but
86.
by pcrh 6mo ago
Alternate source for the comic: https://www.behance.net/gallery/102075221/The-Last-Question
87.
by pcrh 6mo ago
I was replying to the statement that "alcohol is always poisonous". It isn't.
88.
by pcrh 6mo ago
Ethanol is a naturally occurring substance, humans and many animals have specifically evolved ways of processing it. In moderate doses it does no harm. It's almost impossible to avoid ingesting some alcohol during the course of a nat
89.
by pcrh 6mo ago
Thanks! An interesting article. It mentions that "breeding dogs are no longer allowed on the island". I presume this is to avoid a feral population of dogs becoming established. However, I'm unaware that dogs pose particular
90.
by pcrh 7mo ago
Exactly. EU legislation is currently far more respecting of privacy than is legislation in the UK or the US. For various, and unclear, reasons, there is substantial backing to change this.

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