notlob

11 ms·

61.
by notlob 9y ago
Much of large pharma R&D effectively happens through asset acquisition of smaller entities, and I don’t think that is reflected well by budget numbers. Tufts numbers are generally regarded as high. Booth at Atlas puts the cost ranging
62.
by notlob 9y ago
Parent is speaking of a different drug than the article, and it sounds like they are speaking of a new drug.
63.
by notlob 9y ago
How would you propose recouping the cost of developing a New Chemical Entity into an approved drug without the exclusivity provided by IP?
64.
by notlob 9y ago
For annotations and notes I love LiquidText (iOS only, http://liquidtext.net ). It’s great for ebooks and longer reviews, has a nice “accordion” feature for comparing between distant pages, and can help produce nice summaries to
65.
by notlob 9y ago
> I wonder if we can get some DNA from it. From the article: “McKellar said that soft tissue and decayed blood from the tail were found in the amber but no genetic material was preserved.”
66.
by notlob 9y ago
Electrical engineers do not wire houses. Electricians (a distinct profession, also licensed) wire houses. Similar to how chemical engineers are distinct from plumbers. I'm done here, this is not going anywhere productive or enlighten
67.
by notlob 9y ago
> In this scenario, the state has redefined the meaning of "engineer" in a way that is very detrimental. This is backwards from my perspective. Engineering has long been a licensed profession. It is only recently that a gro
68.
by notlob 9y ago
Electrical Engineer is also a licensed profession.
69.
by notlob 9y ago
This misses my point. My point is that while I am a "doctor" I am not a physician, and that even though I use the title in other places it's prudent to be very careful about it in a medical setting because it could be miscon
70.
by notlob 9y ago
Titles can be contextual. I do not refer to myself (a PhD) as a doctor in a hospital because others could incorrectly think I was a physician. This problem is especially vexing for nurses with PhDs.
71.
Oregon punished an engineer for criticizing red-light cameras. He fought and won(washingtonpost.com)
518 points by notlob 9y ago|311 comments
72.
by notlob 9y ago
Why would that be informative? It doesn’t tell you your protein expression levels nor effective enzymatic activity.
73.
by notlob 9y ago
That would actually be the monostable ZF shifter used in some FCA cars.
74.
by notlob 9y ago
> The Toyota "unintended acceleration" bug revealed some tremendously poor quality software. Did Toyota ever recall the affected ETCs?
75.
by notlob 9y ago
It isn’t a great idea. I used to do it (See ID), but it is actually not compliant with the credit card agreement. The post office by me refused to accept cards marked like that.
76.
by notlob 9y ago
N.B., the MISRA guidelines for C were revised in 2012. This critique is directed at an older publication.
77.
by notlob 9y ago
As a confound, your original comment (at present that is) defaults to a collapsed view.
78.
by notlob 9y ago
A bulb was also a neat hack used in the 200A, the first product made by a small and relatively obscure garage startup in Palo Alto: https://en.m.wikipedia.org/wiki/HP200A
79.
by notlob 9y ago
> not to mention that it only works on 'vetted' stretches of road. To be specific GM is following the NHTSA guidelines for autonomous vehicles, which consider Operational Design Domains in the design process.
80.
NTSB: Tesla’s Autopilot UX a “major role” in fatal Model S crash(arstechnica.com)
178 points by notlob 9y ago|215 comments
81.
by notlob 9y ago
> I haven't been government-cleared for anything (as a matter of principle I won't do work for the federal government), but I've been background-checked repeatedly, including by major exchanges, and never once had a proble
82.
by notlob 9y ago
> Every landlord I've rented from has pulled my credit. There is also a separate tenant screening for real estate that, at least for me, seems to be more reliable as an indicator for trust than the financial credit report. It is pos
83.
IBM pitched Watson as a revolution in cancer care, but it’s nowhere close(statnews.com)
128 points by notlob 9y ago|52 comments
84.
by notlob 9y ago
My 80s diesel Benz is barely broken in at 249k miles. It all depends on the car. Ironically, more modern cars will probably not last as long! I can rebuild just about anything on this car, electronics included (most complicated part is perh
85.
by notlob 9y ago
I’ve long wondered if people who extensively use advanced assist systems will see deterioration in manual driving aptitude, and if that deterioration will be restricted to the operating domain for the assist systems or be more general.
86.
by notlob 9y ago
> Many of the current cars are 100% drive by wire (ECU/power brakes/electric power steering), but that doesn't mean anything. Electric power assisted steering. Few cars on the road currently are correctly termed steer-b
87.
by notlob 9y ago
What does the typical circuit for a city street light pole look like, i.e., what voltage is it, what wire gauge, etc.?
88.
Why SAFE notes are not safe for entrepreneurs(techcrunch.com)
4 points by notlob 9y ago|0 comments
89.
by notlob 9y ago
Ondansetron is associated with long QT. The FDA does not like that side effect for OTC meds.
90.
by notlob 9y ago
> If I'm not mistaken, he is an engineer, and even a licensed one too, just not licensed in the Oregonian jurisdiction. You are mistaken: I told you in an earlier reply that the first linked document states he is not licensed to pra

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