natechols

71 ms·

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by natechols 8y ago
I don't watch TV. This is from numerous print sources, but especially The Economist. And you yourself described the failed plan as "as unfavorable a set of exit conditions as possible", so I'm still waiting to hear wha
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by natechols 8y ago
What sort of "good deal" do you think May could realistically have extracted from the EU? Everything I've read has implied that the Brexit options ranged from "poor" to "apocalyptically bad".
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by natechols 8y ago
For a bit of historical perspective, this was the same criticism made of the civil rights movement in the 1960s. Good thing MLK didn't try to follow your advice.
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by natechols 8y ago
Yale University isn't responsible for these societies and has no control over them. They occupy private property and by their very nature lack any formal institutional affiliation with the school. They're simply private clubs wh
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by natechols 8y ago
Those are the authors of the book, and I think that's what became the first chapter.
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by natechols 8y ago
I'd argue that this wasn't "managing the market", it was dropping suicidal economic policies that kept the entire population in serfdom. The state actually gave up a huge amount of control in the process (relative to th
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by natechols 8y ago
The NIH's decision to require open access a year after publication was actually a huge step forward, and that must have been a decade ago now. Pretty much everyone who isn't a publisher would prefer it be immediate, but there&#x2
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by natechols 8y ago
I've thought about this for years, and the fundamental problem I keep running up against is that you'd need to reinvent academic culture and incentives to have any hope of replacing the publication system with something better.
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by natechols 8y ago
In molecular modeling, at some point you're limited either by quantity or quality of input data (for example known protein structures), by the accuracy of your energy function, or by the inability to simulate at long timescales. AI al
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by natechols 8y ago
Sorry, to be clear, there usually isn't any machine learning involved (at least not in the examples I'm familiar with), but the rest of the process is very similar. My point is just that it's not a new workflow and it's
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by natechols 8y ago
You're describing what protein design researchers have been doing already for years already. Except for predicting the desired function, which AlphaFold doesn't do either - as the structural genomics projects of the 2000s found o
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by natechols 8y ago
That makes more sense, but the energy function isn't really a feature of molecular dynamics, anything that does molecular optimization or modeling will have this information built in.
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by natechols 8y ago
The rulebook approach is basically what groups like David Baker's have been doing for years. However actually applying the rulebook is a difficult problem; I expect AI would actually prove much more efficient in the end, especially wi
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by natechols 8y ago
It's not minimizing the accomplishment - it's an impressive technical achievement, but every new advance in computational modeling for the last several decades has been touted as a revolutionary step forward for drug discovery, an
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by natechols 8y ago
Many researchers have already moved on to the next phases, because those are ultimately far more useful problems than the pure guesswork of CASP contests. Of course better prediction tools will mean better designs too, but the existing too
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by natechols 8y ago
gradient descent != molecular dynamics; the latter is simulating forces on atoms, not attempting to optimize a target function. You can use molecular dynamics for optimization too - it can be very powerful, just slow - but I don't t
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by natechols 8y ago
"Liberal" and "conservative" also have very different meanings depending on country and context, and I don't see how opposition to the Stasi or GDR government automatically makes someone a conservative. Gauck was s
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by natechols 8y ago
As far as international law is concerned, I doubt it. Sputnik was transmitting the entire time it overflew the US.
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by natechols 8y ago
One of the consequences of the Sputnik launch was that it basically enshrined the principle that overflying another country with an active satellite was not an illegal act. (That is, the US government decided not to protest, because it mea
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by natechols 8y ago
Full disclosure: I never bothered to read anything of his written after "The Moon is a Harsh Mistress", since the universal consensus seems to be that his later books are very, very strange.
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by natechols 8y ago
I never thought of Heinlein as especially patriotic or nationalistic; he was, on the other hand, a big fan of revolutions against oppressive regimes.
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by natechols 8y ago
The New Yorker article didn't reveal anything that wasn't well-known in the technical community for years, nor did it turn up any instances of misogyny or sexual harassment. They even mentioned that there's no evidence that
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by natechols 8y ago
Obviously my statement was extremely subjective - although I am far from the only person holding this opinion. However in my experience the reason all wind players play Reicha is that there's very little competition in the Romantic er
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by natechols 8y ago
My experience with Reicha is mostly through his wind quintets, which are all competent, but not especially memorable IMHO. Which is very close to how I feel about Haydn. Reicha is actually more famous among woodwind players for popularizi