mylons

22 ms·

211.
by mylons 5y ago
how much do you want to spend? you could do it in a couple days if you use a few sequencers. how long would it take to assemble? how much do you want to spend, etc. how useful is it? not very at the moment. most analysis is still around spe
212.
by mylons 5y ago
of course — so you have to make it accessible to the candidate. using the internal code base is probably not the best choice. we had them write up a small API with specific requirements in the tech of their choice, and tried to have someone
213.
by mylons 5y ago
making the interview process similar to the job is a good first step. when I worked at Invitae this was my proudest achievement from my time there. I suggested that we change the interview process to a paired programming session that were s
214.
by mylons 5y ago
the hallways aren’t empty due to the total compensation and perceived prestige working at a FAANG or similar company offers.
215.
by mylons 5y ago
how is it better than alternatives? this seems like a huge straw-man given almost every company that hires developers thinks they’re a large tech company and mimics their hiring process. it doesn’t seem like serious alternatives have been e
216.
by mylons 5y ago
People get PIP’ed and fired routinely that make it through this process. I think there’s a lot of bias in your response. The process worked for you, you work at a large tech company and it gives you validation. It also makes you feel good t
217.
by mylons 5y ago
tangential question: I'm 37 and think I have ADHD. My partner thinks I do, and when I read posts like this I deeply identify with them. What should I do? Get a diagnosis? My ignorance thinks the only course after that is drugs which do
218.
by mylons 5y ago
unfortunately it's proof that people do not want it.
219.
by mylons 5y ago
this is correct. I interviewed with the company that raised in the fall. They are working purely on products and services for venture capital and those participating in it. Some VCs have been raving about how great these products are on twi
220.
by mylons 5y ago
not in the united states. the early 2021 was the peak, and was never surpassed in the recent uptick.
221.
by mylons 5y ago
the 30 under 30, tho
222.
by mylons 5y ago
maybe related to escalating Russia and China tensions? Letting them know something specific?
223.
by mylons 5y ago
you’re the kind of nerd sniper that gets off on this kind of interview style. it’s a well established phenomenon that LC style interviews do little than to fan the flames of the ego for the interviewer.
224.
by mylons 5y ago
someone took an avi1 recently
225.
by mylons 5y ago
Everyone is flawed. Everyone.
226.
by mylons 5y ago
bwa specifically performs a burrows wheeler transform of a 3GB string. other mapping algorithms usually rely on some sort of indexing of the genome. the program then loads this into memory and queries that index for each “read” (a dna fragm
227.
by mylons 5y ago
yup. that’s the business model for Illumina. it’s very much akin to video game consoles. Illumina might take a hit on selling the machine but makes it up in selling you proprietary reagents.
228.
by mylons 5y ago
you’d likely to have to get the nanopore sequencer in the article or find a lab using Next Generation Sequencing to sequence your DNA and give you “raw data” which are usually fastq files
229.
by mylons 5y ago
ya my first thought was how hard are reagents to get, but probably not that hard. i wasn’t in the lab, i was in bioinformatics so i’m generally clueless on reagent acquisition.
230.
by mylons 5y ago
wow i didn’t know they were that “cheap” now. i used to work for a major competitor to the sequencer you linked, the SOLiD. and i feel like nanopore is the VR of dna sequencing. it’s always just another few years off.
231.
by mylons 5y ago
good luck! it’s not that tough, just a lot of new vocabulary.
232.
by mylons 5y ago
yes. if you wanted to annotate your genome you could “easily” do it on your brand new macbook (this is ram intensive, you probably need 32G). you’d need a reference genome, like https://www.nist.gov/programs-projects/ge
233.
by mylons 5y ago
haha! I felt the same way about Seveneves, although I guess that doesn’t have as much hype. The premise for the opening chapter was so cool, and then the exhaustive descriptions of spaceships and orbital mechanics and what not was just too
234.
by mylons 5y ago
the first chapter of snowcrash is one of my favorite chapters in any book i’ve ever read. the rest of the book is great and goes into some really bizarre territory on how to manipulate humans, as well as looking at the effects of a truly de
235.
by mylons 5y ago
I’m 15% into Cryptonomicon by Neal Staephenson, and it’s living up to the hype. I’ve only read a few of his books: Snowcrash, Anathem, and Fall; or, Dodge in Hell. He’s such a good thought experimentalist and decent novelist. Reading one of
236.
by mylons 5y ago
Maynard Keenan from Tool had a good line about this he’d use in interviews. Something like, “you get a shortcut to transcendence that you spend the rest of your life developing the ability to get their naturally“
237.
by mylons 5y ago
i totally agree with you. i think if you were a small product focused company, you could conceivably have engineers with a PM, and cut it off at that. why a PM? because talking to the customer and getting that feedback is a must, and potent
238.
by mylons 5y ago
"hiding all the behind-the-scenes issues" that COME from the management/ops/marketing/sales layer. it's kinda like a snake eating it's tail.
239.
by mylons 5y ago
the startup i just left did this. they have about 300 employees, and are pre revenue. the process to add a field to an api response was incredibly tedious and sapped my motivation completely.
240.
by mylons 5y ago
you don't deploy it, you go to openai.com and use their API.

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