mattkrause

62 ms·

691.
by mattkrause 5y ago
"Work" has two overloaded meanings here. It might `work` in the sense that it causes the practitioners feel better, without the biochemistry `working` as hypothesized. Indeed, the author points out that many of the practices are p
692.
by mattkrause 5y ago
E. coli is a very common model organism for molecular biology and a really popular tool for generating synthetic proteins. (Yeast too). Bacteria have a neat feature where, in addition to their "main" chromosomal DNA, they also h
693.
by mattkrause 5y ago
FYI: Ohio's interest stemmed from the fact that William McKinley, for whom the mountain was renamed, was born in Ohio and served as its governor before becoming presidents.
694.
by mattkrause 5y ago
The trick is that you should learn either enough ML or enough Python first, so you can identify where the problem lies.
695.
by mattkrause 5y ago
Are there a lot of religions with bans on flash photography? This, to my mind, is a perfect example of people getting carried away. It is definitely the case that dopamine signalling occurs in the retina, but the connection between that and
696.
by mattkrause 5y ago
Sure, but do you find video games more interesting when thirsty? Does chocolate tastes better when eaten without good company? The argument is that lumping everything together is unnecessary: you can disconnect from different things at di
697.
by mattkrause 5y ago
A doctor at Mass General , which is one of Harvard's teaching hospitals. He's also an instructor at Harvard Med, so his claim to a Harvard affiliation seems about as solid as can be.
698.
by mattkrause 5y ago
You might have the wrong date. I have an edition of Dynamical Systems in Neuroscience from 2007 and, having met the author, I'd imagine he might have just been born in 1967.
699.
by mattkrause 5y ago
Eh, I'm not sure I agree with that[0], but even if I did, the government skirting (what you think is) the law once certainly should not be a reason for it to do so again in the future. As it stands, they are legally required to reda
700.
by mattkrause 5y ago
Exactly. Here's literally the law on what goes into a New Drug Application: https://www.law.cornell.edu/cfr/text/21/314.50 The idea is that it serves as the "whole story" of a drug, and includ
701.
by mattkrause 5y ago
I'd bet that no one person has read all 329,000 pages, but I would bet that somebody looked at almost any given page. I'm hedging a bit on "any" because a New Drug Application is supposed to contain "the whole s
702.
by mattkrause 5y ago
The issue is that's not just Pfizer's trade secrets; the documents may also contain PII (e.g., medical history) of those 65,000 people.
703.
by mattkrause 5y ago
They’re presumably hiring for multiple jobs though, which knocks that number right back down. I’ve heard of individual tenure-track jobs attracting 750 full applications. Low hundreds is probably more typical, depending on the school, year,
704.
by mattkrause 5y ago
Has this actually happened? My experience has been that if you walk around a campus, you can find people studying all sorts of ideas. Some of that might even involve intellectual exercises where one tries to make a strong case for a “revo
705.
by mattkrause 5y ago
It’s not obvious to me that this reflects anything special about this particular model for a university. Instead, I think it reflects the utter horrow-show that is the academic job market and, to some extent, the terrible matching in the re
706.
by mattkrause 5y ago
For small amounts, the "lore" is that people response especially well to food. That is, more people will fill out a survey for a Snicker's Bar than if offered the equivalent amount of cash (e.g., $2).
707.
by mattkrause 5y ago
A couple of reasons. Eye trackers are an incredibly common tool for research. They're obviously useful for studying eye movements themselves. This may sound niche, but eye movements are tightly integrated with perception and attention.
708.
by mattkrause 5y ago
Other fields seem to do just fine with this approach. If you interview for an R&D position at (e.g.,) a biotech company, in academia, or one of the National Labs, you're usually asked to prepare a 30-45 minute presentation about yo
709.
by mattkrause 5y ago
I wouldn't put it quite like that, but.... It would be hard to overstate how complicated the nervous and immune systems are. On top of the biology, the provision of medical care is also absurdly complex: there are all sorts of biases
710.
by mattkrause 5y ago
Two things I would want to dig into: - How are the patients selected for transplants? Scarce organs are probably not given to patients who have other serious impairments as well. - How were the (non)-dementia patients assessed? No formal
711.
by mattkrause 5y ago
Fruit and vegetables are pretty popular test objects: they sit nice and still, they have interesting structures (i.e., look cool), and they avoid ethics/safety issues involved in scanning humans or animals. "Phantoms", test d
712.
by mattkrause 5y ago
Dodge v. Ford was basically a perfect storm of saying just the wrong amount. To summarize the case, Ford was sitting on a huge amount of cash. Some shareholders, in particular the Dodge brothers, wanted it paid out as dividends. Ford said
713.
by mattkrause 5y ago
Indeed! It's not even really true: I did some digging in this thread. https://news.ycombinator.com/item?id=23393674 The relevant legal standard is "Don't abuse the company for your own ends", not "y
714.
by mattkrause 5y ago
That seems....very plausible. For other drugs, an amazing amount of effort is devoted to finding something that a) sounds "promising" but b) without making legally-untenable promises. The name `Viagra`, famously, is supposed to e
715.
by mattkrause 5y ago
Specifically, ChAdOx1 is the vector , a platform for making vaccines: there are vaccine candidates using it for TB, MERS, Zika, flu, and a bunch of other things (see here: https://clinicaltrials.gov/ct2/results?cond=&a
716.
by mattkrause 5y ago
I don't think it's either of those: the article mentions Mark Wagner and Liqun Luo, who aren't authors. I think I found it above, via the 2nd link in the article; it goes to a PR piece which ultimately links to the paper.
717.
by mattkrause 5y ago
Actual paper: Wagner, M. J., Kim, T. H., Savall, J., Schnitzer, M. J., & Luo, L. (2017). Cerebellar granule cells encode the expectation of reward. Nature, 544(7648), 96-100. Full text via PMC: https://pubmed.ncbi.nlm.nih.gov
718.
by mattkrause 5y ago
I'm a little disappointed at the framing. This is certainly not the first article to claim that the cerebellum is involved in reward: there was a series of PET studies c. 2000 that reported that the cerebellum encoded reward prediction
719.
by mattkrause 5y ago
No, it wasn't. The Court originally declined to vacate the stay in a 5-4 decision. The fifth vote was from Kavanaugh, who wrote that he thought the stay should be vacated, but wasn't voting to do so because the moratorium was ab
720.
by mattkrause 5y ago
Is doing something that the Supreme Court may later overturn--and bear in mind it was a close decision--actually "illegal"? I could certainly see the argument that it's ill-advised, and indeed, it was struck down a few week

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