mandevil

17 ms·

211.
by mandevil 1y ago
The last time that a major corporation was found guilty for criminal behavior (Arthur Andersen in 2002 for Enron related stuff) the company closed immediately. This has led to problems in the audit industry, where was once the Big 8 audit f
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by mandevil 1y ago
IPO valuation is pretty much always set to undervalue so it gets a good pop(1). The market cap after 90 days of trading (generally speaking when insiders lock-up provisions expire and there is no longer a limit on the number of shares that
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by mandevil 1y ago
I believe GP was quite firmly tongue in cheek.
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by mandevil 1y ago
Wealth inequality is intensely fractal, at every level it is enormous: someone at the 90th %ile household (there are 15 million of these), making 178k (1), can mostly imagine what someone at the 97th %ile, making 350k, would live like (ther
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by mandevil 1y ago
I'm not totally sure what the GP meant, but I think it has to do with the owning/operating organization of the plane not being a qualified (Part 121/135) company for commercial operations. A grandfather-in-law owned his own s
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by mandevil 1y ago
Interesting to see two independent researchers on this. Makes me curious as to what the back-story is? Side project?
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by mandevil 1y ago
If data was reliable, instant, and comprehensive, this might work. Of course, under those circumstances socialism or communism would probably work out even better. It is precisely because data comes out murkily, with a lag - and the effects
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by mandevil 1y ago
I feel like one of the under-appreciated problems with modern society (1) is the sheer quantity of lies we are surrounded with. RTO is just the current most blatant example (2) in the American economy of people saying lies knowing that they
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by mandevil 1y ago
In ~2005 I worked with a world-renowned expert on industrial automation and computer control of machines. He drove a 1989 Mercedes 300 sedan with a manual transmission, which he claimed was the last car made with no software in it at all. T
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by mandevil 1y ago
The thing I keep worrying about is the fate of the store clerk. Retail store clerk was a medium skill/medium prestige job up through the 1970's and 1980's. You needed someone who knew all of the prices for their part of the s
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by mandevil 1y ago
A friend got hired by a defense contractor to be the first developer on a new project! Greenfield developing! It turned out the project was here are 30,000 lines of Fortran77 written by two scientists who got Ph.Ds in Geology in ~1985, plea
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by mandevil 1y ago
This is the same guy, right? Who burned out so totally he ended up working in an Amazon fulfillment center for six weeks? https://www.jasonshen.com/169/
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by mandevil 1y ago
The answer is, the therapy does not improve much. It was controversial when it was approved, because the Phase III clinical trial failed to show statistically significant improvement- lots of people in the FDA advocated against approving th
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by mandevil 1y ago
That second point is what the LUMEOS trial demonstrates is not true: LUMEOS tested a AAV2 vector delivered inside the retina by a surgeon (just like Luxterna) yet instead of 80% of patients showing improvements only 40% did(1). What went wr
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by mandevil 1y ago
This is such a deep hole of complexity. (My wife is a pharmacist, I make computers do what I tell them to, and she has convinced me that her field is far more complex than us software people can imagine.) To pick one story my wife has told
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by mandevil 1y ago
The experience of patients who received Luxterna was that the single most important difference in how large the improvement was and how many complications they had was the quality of the surgeon who delivered the actual therapy. The best su
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by mandevil 1y ago
> Presumably, curing a genetic disorder for a very small number of people using existing technology is low risk and low reward. At the present state of medical understanding, in vivo gene therapy is not low risk, just from a financial pe
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by mandevil 1y ago
We are not close to that. Gene therapies are still very much hit or miss in RCT's, if some biohacker offers you something for 5k you are definitely getting scammed. The first gene therapy approved for in vivo treatment by the FDA, Luxt
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by mandevil 1y ago
This is actually a lot harder than you think because we still don't understand gene therapy well enough to be able to be sure that any given treatment works without the really expensive part, the Randomized Control Trial. In 2017 a gen
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by mandevil 1y ago
At least in the past, Intel owned a dozen 35-50 pax regional jets ( https://www.planespotters.net/airline/Intel-Air-Shuttle-Airc... ) and had regular scheduled flights back and forth between their Santa Clara, Phoenix, a
231.
by mandevil 1y ago
The district court ruled for Google over patents and copyright- that it was not a copyright at all, the Court of Appeals then reversed and demanded a second court trial on whether Google was doing fair use of Oracle's legitimate copyri
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by mandevil 1y ago
Oracle sued Google, and Google won, 6-2 (RBG was dead, Barrett had not yet been confirmed when the case was heard). Supreme Court ruled that by applying the Four Factors of Fair Use, Google stayed within Fair Use. An API specification ends
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by mandevil 1y ago
401(k)'s almost always have terrible choices for funds, because of the principal-agent problem. The agent of the company makes the choices on what funds are available but it is the principals as employees who pay the fees. In half-a-do
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by mandevil 1y ago
Vanguard Target Date 2045 (suitable for someone born in 1980, looking to retire in about 20 years) is, as of September 2024, at 50.3% Total US Market Institutional Shares, 33.2% Total International Investor Shares, 10.9% Total US Bond Inves
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by mandevil 1y ago
https://en.wikipedia.org/wiki/Streisand_effect
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by mandevil 1y ago
On the other hand, I find that "someone who has read all the blogs and papers and so can suggest something you might have missed" is my favorite use case for LLM, so seeing that it can miss a useful (and novel to me) idea is annoy
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by mandevil 1y ago
Only because traditionally the airplane industry measures specific impulse on just fuel flow, completely ignoring the oxidizer and atmospheric nitrogen. If you calculate like for like, including the air, jet airplanes have significantly wor
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by mandevil 1y ago
That is not how international law works, you don't get to say "we are a new country and therefore not bound by treaties that earlier forms did." This principle was established when Nazis were convicted for war crimes at Nurem
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by mandevil 1y ago
International space law (starting with the Outer Space Treaty of 1967) says that nations are responsible for all spacecraft they launch, no matter whether the government or a non-governmental group launches them. So a server farm launched b
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by mandevil 1y ago
It sounds good at the one sentence level. When you need to write more about the topic, the problem is that oxygen makes up only about 20% of the air. So you have need to accelerate all of this N2 that gives you nothing in energy and the res

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