koeng

32 ms·

391.
by koeng 6y ago
That would only be true if their tests work well. In my experience, IgG and IgM suck big time, and I wouldn’t trust results. Would love to see one of those randomized studies with qRT-PCR tests.
392.
by koeng 6y ago
The Spanish flu was a totally different disease though.
393.
by koeng 6y ago
Antibody production in vertebrates is an amazing example of an extremely efficient directed evolution system within our own tissues. There is some interesting work being done to mine antibodies from people who have recovered from diseases a
394.
by koeng 7y ago
Is there a way to be a host and then pin other people's content that I like? I'd love to be a host that pins public content without an explicit financial transaction.
395.
by koeng 7y ago
Is there anyway to pin skynet files using storage rather than Sia, or a way to download skynet files using the command line (independent of a curl request from a portal)?
396.
by koeng 7y ago
I’ve been thinking of deploying dat for Nanopore DNA sequencing, but recall something about dat not being great at handling that kind of data. Does the newest version of dat handle large files well (10gb)? Does it handle tons of files neste
397.
by koeng 7y ago
Possible? Yes. Practical? Not for 2-3 decades when DNA synthesis capacity gets good enough to synthesize full animal genomes. In terms of raw synthesis power, we do have the ability to synthesize billions of base pairs, but you're goin
398.
by koeng 7y ago
I'm fairly new to programming in Prolog - how does Scryer Prolog compare to more common implementations like Swi Prolog?
399.
by koeng 7y ago
Is there any reason why Maude is cooler than Prolog? Concurrency? Also - will email you!
400.
by koeng 7y ago
I've heard Datomic was made by Clojure people and is really good software too, though unfortunately proprietary.
401.
by koeng 7y ago
Thanks! Signed up.
402.
by koeng 7y ago
Will do Will! Small world.
403.
by koeng 7y ago
That's amazing! I've never found that site before but I'm going to read some of their papers. Thank you for linking
404.
by koeng 7y ago
I can't find that much information about it online, but it looks great from a outside perspective! Wish they had a paper or something.
405.
by koeng 7y ago
In synthetic biology, the application is super clear. Let's say we want to make cocaine (or related compounds) in yeast ( https://www.nature.com/articles/s41467-019-11588-w ). Well, we know the biosynthetic pathway
406.
by koeng 7y ago
Not yet, I was in the middle of building a script to convert metacyc ( https://metacyc.org/ ) to a Prolog database when COVID-19 hit - now I'm distracted figuring out the logistics of doing local production of diagnostic
407.
by koeng 7y ago
Prolog. I think that genetic logic can largely be expressed in Prolog to enable doing some crazy stuff that hasn’t been explored yet. It’s crazy to me that synthetic biology hasn’t really used logical programming yet for gene design.
408.
by koeng 7y ago
Basically, the variance in melanin is what causes different eye colors. So, if you have a gene that produces melanin, and then turn it's expression down, then you might get bluer eyes. The complicated part is that a lot of genes actual
409.
by koeng 7y ago
technically true, the best kind of true
410.
by koeng 7y ago
This activity can sometimes be annoying in biology experiments, especially when you get down to the bacterial size and do measurements on the population. Think the average expression of gene X is 100? Well, it is, with 90% of the population
411.
N95 masks are being exported from the US(forbes.com)
30 points by koeng 7y ago|5 comments
412.
by koeng 7y ago
Sorry for late response, but here is for the reverse transcriptase plasmid - https://en.wikipedia.org/wiki/VS_ribozyme Here's for phage CRISPR - https://www.nature.com/articles/s41586-020-2007
413.
by koeng 7y ago
Open source equipment has been tried a lot in the DIY bio space, but a lot of it falls short because the used market is too good in biotech IMO Lots of medical and academic labs liquidate, and you'd think that the market would compensa
414.
by koeng 7y ago
Sure, or you could just go swab sick people and keep it in storage for a while. More people want to build than destroy IMO. If we tested in the synbio dream, this outbreak would have never happened in the first place.
415.
by koeng 7y ago
Biotech companies are responding well because they have all the production lines built out to rapidly respond. Academics and other government funded researchers are responding (personal communication) but they can't do so at the speed
416.
by koeng 7y ago
I know a guy who is trying to arrange serological testing for Union employees in the LA port area with this exact idea. The problem is bulk ordering tests - you need a massive investment (about 750k for minimal order size of 100k tests), wh
417.
by koeng 7y ago
In the future, I'm hoping some of the dreams of synthetic biology come true (basically, decentralization of biotech). I work on that problem in close collaboration with a lot of community lab spaces, and it is surprising how many have
418.
by koeng 7y ago
I think usually the gene name isn't changed. For example, I've noticed that bacterial genomes tend to start with the dnaA gene (many different sequences). I like to think of genes as their amino acid or dna sequence only, and inte
419.
by koeng 7y ago
I'm pretty sure you could simply mine microbiome data. They have lots publicly available.
420.
by koeng 7y ago
Yep, that's correct. There are a lot of things that biologists tend to believe are out there, but are waiting for examples, which makes these kinds of discoveries very pleasant surprises. For example, it could kinda be assumed that we

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