koeng

28 ms·

301.
by koeng 6y ago
If you want to have your mind blown even more, remember that all of these molecules are compressed in a super tight space (not a lot of space around them). Here is what a small bacteria would actually look like (artist rendition of course)
302.
by koeng 6y ago
Posted elsewhere, but https://applesearch.org/ is a super cool site of a mans journey to discover lost apple varieties.
303.
by koeng 6y ago
I didn't know the 'cue get go', that could be very useful for a Go project I'm working on. Thanks!
304.
by koeng 6y ago
Your github link for cuelang gives a 404. I've been interested in cuelang for a while but just haven't found a real use case for it. For validating incoming data, JSON Schemas tend to do the trick and are widely distributed, and f
305.
by koeng 6y ago
Some answers here - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011006/ TL;DR prokaryotes can grow faster due to the structure of their genome. Also, biology doesn’t care what works best, it only cares abou
306.
by koeng 6y ago
There are tons of insects with novel endosymbionts. For example, Camponotus ants have some novel endosymbionts - https://pubmed.ncbi.nlm.nih.gov/8866472/ . There are even synthetic endosymbionts nowadays (e coli in yea
307.
by koeng 6y ago
Why would you think that the prokaryotic-to-eukaryotic jump is higher? If it is engulfment of organelles like mitochondria, that happens all the time. There are fairly good models of the evolutionary tree and how it could happen over time[1
308.
by koeng 6y ago
I'd like to point out that Tom Knight, one of the scientists mentioned, now is considered one of the Godfathers of synthetic biology. He made a pivot in the late 1990s/early 2000s. If you'd like to read one of the papers that
309.
by koeng 6y ago
Do you have links to any of the tools you made?
310.
by koeng 6y ago
Any recommendations on good open source CI / CDs? Right now I just use github actions, but am interested in other self hosted options.
311.
by koeng 6y ago
Should check out Opentrons! I run a couple out of my home lab and they're great for automating biotech procedures. You can get 90% the way to full automation with like 10% the cost.
312.
by koeng 6y ago
That's unfortunately much more into the medical field, so I'm not really sure where to start. I only really work with single celled organisms.
313.
by koeng 6y ago
It only fits the startup model if you know what you’re doing, which is in pretty short supply. You can definitely create a shockingly good lab for ~3000 though.
314.
by koeng 6y ago
Synthetic biology is pretty good for creating things. Agree with other points tho
315.
by koeng 6y ago
A book I loved when I was first learning is called “Unraveling DNA” from 1988. I remember it reading like a detective novel, as back then the folks writing were mentored by the OG molecular biology folks. It can be yours for only $4 https:
316.
by koeng 6y ago
What are you interested in? Synthetic biology? Bioinformatics? Something else? Biology is really broad - As an analogy, not sure if you’re interested in how to build a gaming computer or want to learn how make web apps.
317.
by koeng 6y ago
It is awesome that you're getting started in this community! Here are just a few very biased recommendations of interesting folks for your podcast: There are a bunch of different cliches (community bio vs biohacking vs citizen bio vs g
318.
by koeng 6y ago
I started out in computers, spent most my career in biotechnology, and right now spend about half and half in each (for the most part, I run a DNA cloning foundry where I clone new sequences. Need lots of software for that). If there is one
319.
by koeng 6y ago
Formate can also be used directly for biomass generation, meaning you can feed it to a vat of cells instead of glucose or sunlight. If you’re willing to eat cells, kinda solves a lot of food generation issues.
320.
by koeng 6y ago
^ Listed the 2 that I think really need help above Biology isn't nearly as organized as software, so the bio communities are a bit disparate. It also doesn't help that biology has such a large scope. From my experience, conference
321.
by koeng 6y ago
Sure! One thing I have to note though - the field is fundamentally different than software engineering. In software, it isn't unusual for someone to maintain a software package for a long time, and for other people to contribute. In bi
322.
by koeng 6y ago
They aren't many (most of it is closed source). The one package that is used a stupid amount is the Biopython package. Most synthetic biologists I know are pretty much only trained in python (because bioinformatics), so use that packag
323.
by koeng 6y ago
It's pretty hard to compare biology to programming, mainly because analogies start to break down and it becomes fundamentally different. The genome is just a collection of atoms that has figured out how to trick other atoms do work (in
324.
by koeng 6y ago
I've been in synthetic biology / DIYbio for the last ~8 years, and recently worked 3 years in Drew Endy's lab and got a decent perspective on how things went down throughout the years. If there is something the computer hacke
325.
by koeng 6y ago
Synthetic biologist here - I don't think mitochondrial base editing should be included. The basic technology that enabled it, TALENs, were actually mentioned. Mitochondria is just a specific use case of that very powerful technology.
326.
by koeng 6y ago
Yep, it’s a small self hosted cluster on my own server hardware (VMs on Proxmox) I’m sure k8s would work, but k3s made it really easy for me to get going so now just has inertia.
327.
by koeng 6y ago
I think minikube is for local usage. I use K3S for deploying an actual production cluster, so I’m more curious about how micro-k8s acts on that scale
328.
by koeng 6y ago
Anyone know how this compares to k3s? I’ve been using k3s for a while, and there have been a few bugs that made me a bit annoyed
329.
by koeng 6y ago
If you want beautiful representations of what cells look like, highly recommend David Goodsell’s pictures. They’re highly regarded in the field of biotech
330.
by koeng 6y ago
AFAIK there aren’t methods to do that in vivo, unfortunately.

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