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jryb
searching PlanetScale…
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11 ms
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91.
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by
jryb
3y ago
You've misunderstood the "right" way's purpose. It's right because it solves a problem in a particular context, not because it's the best way in all contexts. You're not coordinating with other humans, so
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jryb
3y ago
This is like asking if your band needs a horn section. Depends on the genre. Just make the songs you wish existed.
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jryb
3y ago
It's hit and miss but the responses i get are all super detailed and usually quite helpful. I've never had interactions like yours. I'm mostly coding in Python with some Rust fwiw
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jryb
3y ago
But where are you getting that pure seawater from? If it's anywhere near the outlet, there's a scale at which the concentrated brine will affect the salinity of your inlet.
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jryb
3y ago
When I was apartment hunting, I asked about this at a place that had smart locks, and they said I just had to fill out a "Reasonable Modification" form (or something to that effect) and they'd install a traditional lock.
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jryb
3y ago
It also works fine for me, I've been using it for a few months now without incident, on iOS 17 currently.
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jryb
3y ago
The same thing happened to me! Except they gaslit me for a while, telling me it was possible, then ignoring every communication. Never again.
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Noise Expressions 2.0
(factorio.com)
2 points
by
jryb
3y ago
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0 comments
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jryb
3y ago
There's a pretty consistent slope in the plot since 2012, and the steepest point was in 2012-2013, so it's probably negligible relative to other factors.
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jryb
3y ago
ZFNs are difficult and slow to engineer. There are certainly tradeoffs but the fact that almost the entire industry is using CRISPR-based approaches tells you where things lie on balance
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jryb
3y ago
It does seem unremarkable sometimes, but every now and again I'll accidentally search for something in a private browser session (which defaults to google) and I'll immediately think, "these results are terrible, what happene
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jryb
3y ago
scikit image replaced lenna with a picture of astronaut Eileen Collins: https://scikit-image.org/docs/stable/api/skimage.data.html#s...
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jryb
3y ago
I've been seeing these stories pop up lately but i haven't noticed any slowdown or unblockable ads. I'm just using ublock origin with firefox on linux, has anyone with the same combo gotten hit by these issues?
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jryb
3y ago
Are those people really double checking their previous sources of information though?
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jryb
3y ago
This particular treatment can't. They perform the gene editing on cells outside of the body before transplanting them back into the patient.
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jryb
3y ago
They augment those with their own index (named teclis).
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Semantic search using protein large language models
(biorxiv.org)
3 points
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jryb
3y ago
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0 comments
108.
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jryb
3y ago
Yes, though I haven't done any web development in a decade, so it's more of an enabling technology since I couldn't be bothered to relearn everything. I wrote most of an Anki replacement in a weekend recently and i don't
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jryb
3y ago
So many foundational bioinformatics tools are broken and I just want to rewrite them all.
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jryb
3y ago
They do have energy producing mechanisms: cells! The key to understanding this is, in my mind, to not put labels on things, and just consider how information encoded in genomes moves around. Also, all of the interactions that I've read
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jryb
3y ago
Virophages (up until now, as far as I know) have only been observed to interact with their host phage inside of a prokaryotic cell.
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Oxide Hiring Process
(rfd.shared.oxide.computer)
73 points
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jryb
3y ago
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125 comments
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The Eternal Value of Privacy (2006)
(wired.com)
1 points
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jryb
3y ago
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0 comments
114.
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jryb
3y ago
> Maybe today's RNAi solutions are provably safe, but what about some AI concocted future version I'm actually finding it hard to imagine a scenario where you would accept any invention of any kind. Try to think of an invention
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jryb
3y ago
Would you have rejected antibiotics if you were around when they were invented? There's a cost to always being skeptical. RNAi was discovered in 1998 and is very well-studied. There's really no room for surprise here. It's ha
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jryb
3y ago
I did the BLAST search, available here for the next two days: https://blast.ncbi.nlm.nih.gov/Blast.cgi?CMD=Get&RID=KE1GEND... No hits, meaning no part of the human genome is targeted by this. Not that it matters, see my
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jryb
3y ago
>really absurd that we continue creating things no one's body evolved to tolerate Your body literally produces enzymes to digest RNA. In the duodenum, specifically. We actually did evolve to do this.
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jryb
3y ago
The other response is pretty good. I would add that you won't be injecting this food into your bloodstream unless that's how you take all of your meals. Your body also produces enzymes that degrade RNA in the duodenum. And this pa
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jryb
3y ago
It's an RNA that has no homology to any part of the human genome. What is the danger here?
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jryb
3y ago
The headline is clearly meant to give laypeople the impression that it makes permanent changes to pest (and presumably human) consumers, so I think it does need to be pushed back against. You're also assuming humans have homology to th
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