jostmey

33 ms·

331.
by jostmey 7y ago
The method of optimization probably has little to do with the interpretability of the model. Gradient optimization (i.e. backpropagation) can be used to fit logistic regression models, which are interpretable. Evolutionary algorithms can be
332.
by jostmey 7y ago
The article seems to blame the Bayh–Dole Act and similar events that allowed Universities to sell government funded research results to the pharmaceutical industry. I don't believe this is the problem--the Bayh–Dole Act incentives new
333.
by jostmey 7y ago
I was riding on an airplane back to Chicago after visiting Dallas. As the plane took off, the woman next to me started crying uncontrollably. Sometime before takeoff, she had just learned that her husband was murdered. I got the f_ck out of
334.
by jostmey 7y ago
I lived in Chicago for 8 years. Here is my take on how it got so bad: 1) Decades ago, instead of raising taxes, the city started borrowing money and issuing deferred payments, such as excessively generous retirement packages (instead of rai
335.
by jostmey 7y ago
Does the Microsoft Office executable file even come in a 64bit package? It's not Ubuntu's or Wine's fault
336.
by jostmey 7y ago
I would be worried that the deep neural networks would fill in the blanks with prior information from other patients, which might be incorrect. In other words, the neural network imagines what should be there, and does not faithfully repres
337.
by jostmey 7y ago
In 1913, HG Well's wrote about a major war ending in the use of atomic weapons. It would seem that some individuals truly are prophetic. https://en.wikipedia.org/wiki/The_World_Set_Free
338.
by jostmey 7y ago
Corporations are people too! So yes, I guess they can be consrcipted
339.
by jostmey 7y ago
Cough, cough. And what makes you think the speed wasn't inflated.
340.
by jostmey 7y ago
Except that people will stop using google if it can’t help them find useful information. Google’s leadership seems to not understand or not care about how the internet works
341.
by jostmey 7y ago
Ha! I remember buying a mac with a disk drive right after the Apple started offering macs with solid state drives. After upgrading the OS, it mac became super sluggish--Apple didn't support the computer for more than a few years.
342.
by jostmey 7y ago
And predicting protein function is not that hard either. The ground truth labels are often determined by sequence alignment similarity, not by experiment. So the results are far from profound
343.
by jostmey 8y ago
And diseases spread exponentially. Anything that exhibits exponential growth, whether it be disease or Moore's law, requires a different mindset
344.
by jostmey 8y ago
These students could probably make a lot more on the open market. The Universities advertise it as a good deal, when in truth it is not
345.
by jostmey 8y ago
I've seen a falcon launch (not the falcon heavy). It is indeed amazing
346.
by jostmey 8y ago
And allow for students to file for bankruptcy on their student loans. That will force colleges to slash their insane budgets and stop building luxury dorms, new stadiums, and lay off the countless and unnecessary admins. Salaries for adjunc
347.
by jostmey 8y ago
People don't understand how hard it is to get tenure. You have to win grants from the NIH to get tenure. Why? Because for every grant the NIH gives to scientist, the Universities tack on indirect costs (whatever that means) allowing th
348.
by jostmey 8y ago
I don’t even want to visit San Francisco anymore. Why would the writers want to? I’m making a point about how bad it’s become in San Francisco relative to the rest of the US
349.
by jostmey 8y ago
I haven’t read the article, but I have been following the story on the news. I think ultimately the Chinese government will fail. Religion is stronger than government. Virtually every human society has had religion, And religion has existed
350.
by jostmey 8y ago
It's a testament to two things: 1. Biology is hard, unimaginably harder than writing a piece of software, for example. 2. The way research is funded is horribly inefficient and in serious need of an overhaul. I'm all for pouring m
351.
by jostmey 8y ago
The screwed up taxes is a symptom of a dysfunctional government. The fix is to address the root cause--reducing excessive lobbying that seems to control the government and implementing a direct democracy that puts the government better unde
352.
by jostmey 8y ago
There are already a small number of research groups trying to identify tumor specific immune receptors and then use those immune receptors as a treatment for the patient cancer. The process is lengthy and expensive but promising as a treatm
353.
by jostmey 8y ago
You did an amazing job coming up the adaptive immune system and the research we’ve done. I am surprised that our approach worked. There must be some common signature shared among a subset of immune receptors between patients with the same c
354.
by jostmey 8y ago
We are currently in the process of checking if we can find disease signatures in easier to access tissue like blood
355.
by jostmey 8y ago
Right now we are focused on diagnosing cancer earlier and identifying the most effective treatment options. Generally speaking, the earlier a cancer is detected, the better the chances of survival. This study demonstrates that we can distin
356.
by jostmey 8y ago
Author here. The immune system is known to participate in a cancer response. With DNA sequencing, we can sequence the immune receptors in a tumor. From each tissue sample, we get a set of immune receptor sequences. In this study, we compa
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Tumor Specific Immune Receptors Computationally Identifiable(cancerres.aacrjournals.org)
44 points by jostmey 8y ago|12 comments
358.
by jostmey 8y ago
That doesn't make any sense. Who sets the price?
359.
by jostmey 8y ago
Here's what will probably happen. A handful of websites and news outlets will create blanket legal agreements allowing anyone to freely link to their content. There may be some online paperwork that flies back and forth between the con
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by jostmey 8y ago
Not really. Lysenko's ideas sort of imply that you can "will" biological changes. A giraffe can "will" a longer neck in its offspring by stretching its neck to reach the top of the branch. Nothing could be farther f

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