jleyank

5 ms·

61.
by jleyank 3mo ago
Novo Nordisk was first to market with a pill-form for GLP-1 as I recall.
62.
by jleyank 3mo ago
You could compare ibuprofen and naproxen. One lasts 4-ish hours while the other, having different functionality, lasts 12-ish hours.
63.
by jleyank 3mo ago
How about this one, although it covers the context of the times…. https://www.amazon.ca/Colossus-Bletchley-Parks-Greatest-Secr...
64.
by jleyank 3mo ago
I assume this is a PhD in CS or some computer related field. In the case of Chemistry, the PhD is the required degree to get above the technician grades (BS, MS). People with a BS and a good pair of hands in the lab can eventually reach t
65.
by jleyank 3mo ago
Puerto Rico makes pharmaceuticals, so if it can be built there it can be built in Canada or wherever. No high-tech workforce in PR, and tax games can be played anywhere. And Trudeau, to many people's annoyance, bought Alberta a pipel
66.
by jleyank 3mo ago
Some things that are shipped from the us to foreign lands could be shipped from Canada for similar costs. Food, for example, or minerals or oil. These are things shipped in bulk “elsewhere”. Canada, as far as I can tell, has lots of such
67.
by jleyank 3mo ago
AI regurgitates what it's been trained on. Life science research has a change of actually learning something that has been previously unknown. Not statistically, but through increased understanding of natural processes. If you're
68.
by jleyank 3mo ago
Doctor Who discussed this in detail.
69.
by jleyank 3mo ago
If that Congress thingie I read about years ago was active, they could straighten these things out. But it seems that was a mirage.
70.
by jleyank 3mo ago
There's a whole lot of middle-level countries that can/should act like the Internet and route around damage. With motivations on both sides, trade agreements can be reached more quickly. And there's trade to/from the U
71.
by jleyank 3mo ago
They just declared CUSMA dead, so the negotiators should pack up and go home. Tit for tat actions can be reconsidered, digital taxes, etc. There's no point in talking to "Trump's people" and given that Trump doesn&#x27
72.
by jleyank 3mo ago
You can quibble over the specific number, but retiring without a paid for domicile is a tough road. Those with retirement on the horizon should think about where they wish to settle in and start planning for a place to live. Use those work
73.
by jleyank 3mo ago
Possibly, but unless things changed recently a masters in chemistry from a us “research oriented” school is a consolation prize. I can see such departments having candidates fulfill their prep work elsewhere, getting a masters in the proce
74.
by jleyank 3mo ago
Going to make grad school in research-oriented fields rather difficult, as they tend to go longer than 4 years unless everything works the first time or the department isn’t full of 5 semesters of candidate work (courses, cumes, prelim). B
75.
by jleyank 3mo ago
Listening to those pushing AI, why should we fund open source developers when we can reproduce their work with a few judiciously chosen LLM prompts? Perhaps the AI companies should fund FOSS so as to get more solutions to memorize but norm
76.
by jleyank 3mo ago
This was going to be my answer - I would bet that Trump, oil companies and (soon) defence contractors would have been the profiteers. But the OP said it better.
77.
by jleyank 3mo ago
Left-leaning and major? No. Considering the countries that the US is compared to, there's not really a centre-leading major news source, either.
78.
by jleyank 3mo ago
This will go down GREAT... Gulf oil will have to handle a 20% tariff vs. the rest of the world to get to market. Fertilizer, etc, anything made in the Gulf will be hit with this tariff independent of any trade agreement that might be in p
79.
by jleyank 3mo ago
You'd have to come up with the criteria for "best" but as an old hacker, "from MIT or Bell Labs" comes to mind as where to look. Maybe some of their spinoffs, but those sites did amazing things with basically nothi
80.
by jleyank 3mo ago
Nate's sheet is showing...
81.
by jleyank 3mo ago
1972... One of the things we hackers did, when not doing Life or Star Trek was implement non-paper versions of CARDiac, the paper computer. The kind of task that made it easier to understand all that was interacting when a program ran (bo
82.
by jleyank 3mo ago
There was no guarantee it was the last significant mutation. Long Covid is a thing which many are still fighting, so delaying eliminating restrictions was a safe decision. Vaccine uptake was not uniform.
83.
by jleyank 3mo ago
I didn't see a mention of paying off a place to live. Going into any form of retirement with a mortgage is a real problem. It's possible to avoid ownership if the rental market is reasonable, but ya gotta live somewhere. Dealing
84.
by jleyank 3mo ago
This is (or is becoming) a problem particularly with index funds/ETF's that use market-value to weight ownership. You can certainly find out the top 10 stocks in an index, and can probably get detained information on funds you ar
85.
by jleyank 3mo ago
Are they forgoing living together, forming a financial partnership or just forgoing the ceremony? There's a huge difference between living solo and just not bothering getting a license (see Quebec). Although those lacking the paper m
86.
by jleyank 3mo ago
The world was lucky the omicron mutation chose virulence over lethality - it could outcompete the older, more “effective” strains. This coupled with vaccines, isolation and antivirals (and treatment changes) kept the count down. A differen
87.
by jleyank 3mo ago
They had done safety and effectiveness testing before deployment back then. These are retrospective studies using a real large dosing and placebo population. The closest to “untested drug matter” that existed was the antibody cocktail that
88.
by jleyank 3mo ago
Cars and airplanes were probably the tech stocks before the transistor. But don’t sell pharmaceutical stocks short as the correct stock at the start of a hot drug prints money. Look at Ozempic and montjaro, look at statins, look at painki
89.
by jleyank 3mo ago
Remember that tariffs are paid by the importer. So, unless Canada or Mexico mirror the US tariffs, USians are going to be the people facing higher prices. And if the tariffs succeed with US companies taking over import business the prices
90.
by jleyank 3mo ago
Ctran and Fortran look similar if you ignore much of the flexibility of C and help the optimizer out re memory overlap. Wave the checkbook and you’ll have programmers. Way easier than COBOL.

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