jhbadger

28 ms·

601.
by jhbadger 2y ago
Define "hot war". There have been plenty of fighting in border regions of India and Pakistan in recent years, and both have nukes. India since 1974 and Pakistan since 1998.
602.
by jhbadger 2y ago
Yes, the chemical structures can look very different when drawn in the 2D manner, but that's why 2D structures aren't very useful for understanding binding, much as primary sequences of proteins aren't that useful. Morphine a
603.
by jhbadger 2y ago
Not necessarily "of course", although this seems to be the case. Outside of Greece people are more interested in the Homeric, Attic, and Koine forms for cultural and religious reasons.
604.
by jhbadger 2y ago
Reminds me of the "Pipedream" package on the old Cambridge Z88 laptop https://en.wikipedia.org/wiki/Cambridge_Z88 It had a combined spreadsheet/word processor. No, not as separate modules like Microsoft
605.
by jhbadger 2y ago
Perhaps we are using "structure" in different senses. Yes, it is possible to generate a molecule with a chemical structure unlike any biological molecule and have it bind to a protein, but it can only do so if its 3D structure is
606.
by jhbadger 2y ago
But even drugs made by combinatorial chemistry still generally end up being analogues of natural products even if they aren't derived from them. As Leslie Orgel said "Evolution is cleverer than you are"; chemists are unlikely
607.
by jhbadger 2y ago
And a fair chunk of pre-WWII Germany ended up in Poland. Poland basically moved westward, losing parts in the east and gaining territory in the west.
608.
by jhbadger 2y ago
Protein structures are similar to each other because of evolution (protein families exist because of shared ancestry of protein coding genes). It's not a weird coincidence that helps ML; it's inherent in the problem. Same with dru
609.
by jhbadger 2y ago
VisiCalc, surely. Lotus 123, much like Excel, was just following in the footsteps of the original spreadsheet. https://en.wikipedia.org/wiki/VisiCalc
610.
by jhbadger 2y ago
Well in 1912, the physics prize went to a guy who designed a better light for light houses and buoys to prevent shipwrecks! Actually, most early Nobels went to practical things. https://en.wikipedia.org/wiki/Gustaf_Dal%
611.
by jhbadger 2y ago
Of course there's another reason why physics PhDs are working on ML these days -- it's also the same reason so many of them are Wall Street quants.
612.
by jhbadger 2y ago
It's almost impossible now. NotebookLM really impressed me. I knew voice synthesis has gotten better than Stephen Hawking's "voice" but I really wasn't expecting having two realistic voices with emotions that even b
613.
by jhbadger 2y ago
Although if you read the Frank Herbert's Dune books you see that Card was kind of doing the same thing with Ender as Herbert did with Paul. The first books of both series set up the protagonist as a hero, and the later books deal wit
614.
by jhbadger 2y ago
It was sad that Sagan died before the New Atheism movement started -- in many ways the "The Demon-Haunted World" is sort of the same book as Dawkins' "The God Delusion" but Sagan made his arguments in a more level-h
615.
by jhbadger 2y ago
I get the argument against AI tools when it's about them not working as well as the hype says they do, but not when they are the "how dare you use a tool that makes it easier for you! That's cheating!" argument. When I w
616.
by jhbadger 2y ago
And from the 1920s to the 1960s, jazz was pop music. It isn't seen quite as highbrow or obscure as opera, but at least in the US, you are far more likely to hear jazz (and opera) on public radio and not commercial stations. It's t
617.
by jhbadger 2y ago
And even when it is technically right it often goes off on tangents not in the paper -- for instance I fed it one of my papers on a pipeline to analyze microbiome data and it spent half of the "podcast" on talking about how import
618.
by jhbadger 2y ago
But still, the bank that created the prize went to an awful lot of effort to make it seem like it was a Nobel. There are awards in every field. Advertising executives even have an award of their own called the Clio. Imagine if they had be
619.
by jhbadger 2y ago
Yeah people used to say in the late 1990s "Linux enthusiasts want it to kill Microsoft, but what it really is doing is killing Sun".
620.
by jhbadger 2y ago
Same for casinos. That's why they kick you out if you win too much or too often. They don't need to prove you did anything wrong like cheating. If you aren't making them money you're out.
621.
by jhbadger 2y ago
It's a completely unrelated story. The idea is it is like "American Horror Story" or "True Detective" where each season is a self-contained story.
622.
by jhbadger 2y ago
Not really. Replication is where you do exactly the same experiment as someone else and see if you get the same result or not. Nobody has tried this with Calhoun's universe experiments (they would probably cost too much, be hard to g
623.
by jhbadger 2y ago
He did a sketch on SNL back in the day making fun of his scholarly background, suggesting that he originally was going to title his famous song "Bobby McGee and I" before taking a course in "how to speak country".
624.
by jhbadger 2y ago
Not everywhere. All the grocery stores near me are either Albertsons/Kroger owned, or from smaller chains (Fresh Market, Trader Joe's). And Whole Foods, but that's Amazon now.
625.
by jhbadger 2y ago
Well, I wrote games as a child in BASIC in the 1980s which weren't on the same level as the commercial assembly-language games. but I still enjoyed doing so.
626.
by jhbadger 2y ago
I'm (or was) a hobbyist programmer on Android. I have a handful of free apps but Google has made it so onerous to actually get things in the store these days. I've given up; it may be worth the time of a big software studio to han
627.
by jhbadger 2y ago
>Look at all the games that flop on Steam each year. These are made by professionals. It's disheartening for kids when the thing they've worked hard on simply isn't fun — particularly when they share it with friends and ar
628.
by jhbadger 2y ago
Absolutely. It is probably the best existing example of the classic department store (not discount store like WalMart or the current version of Macy's) that is basically already gone in the US.
629.
by jhbadger 2y ago
Even Macy's (which is what took over Marshall Field's) is a far, far inferior experience to classy classic stores like Marshall Field's.
630.
by jhbadger 2y ago
UV is definitely higher -- there are about 300K new skin cancer cases per year world wide and about 60K deaths per year from it. Most (although not all) of these are due to UV exposure. That being said, before you blame the sun itself, a lo

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