j_bum

8 ms·

91.
by j_bum 1y ago
It is awesome. But what I’ll say is, ideally they would demonstrate whether this model can perform any better than simple linear models for predicting gene expression interactions. We’ve seen that some of the single cell “foundation” models
92.
by j_bum 1y ago
Just a heads up, your URL 404’s
93.
by j_bum 1y ago
I'm not sure I understand what's going on here. Maybe a broken link? When I click to play, there is no Wordle-like game. It's a shape tracing game. Am I missing something?
94.
by j_bum 1y ago
> “We have a cat and a dog and a child and an adult in the same room,” he said. “Why not an A.I.? Because pets are living creatures with agency that form emotional bonds to their owners. Pets also can’t sycophantically talk back to us. I
95.
by j_bum 1y ago
No problem! I’d love to hear any approach you’ve taken as well.
96.
by j_bum 1y ago
Sure thing. Here is an example set of the agent/spec/to-do files for a hobby project I'm actively working on. https://gist.github.com/JacobBumgarner/d29b660cb81a227885acc...
97.
by j_bum 1y ago
This was a fun read. I’ve similarly been using spec.md and running to-do.md files that capture detailed descriptions of the problems and their scoped history. I mark each of my to-do’s with informational tags: [BUG], [FEAT], etc. I point th
98.
by j_bum 1y ago
I’m almost 30 and made this change about a year ago. I now rotate between high rep (sets of 20 rep max ) and medium weight weeks (sets of 8-12 reps). My joints haven’t ached in a while and I’ve become much less prone to random muscle tweak
99.
by j_bum 1y ago
Best of luck for your continued recovery. Keep at it. I can’t tell you to do this because I don’t know your medical history, but slowly working your way up to medium weight training can also be a game changer. Re: squats, Romanian deadlif
100.
by j_bum 1y ago
Would you be willing to point me to a primer of how I can get started with building agents? This week I experimented with building a simple planner/reviewer “agentic” iterative pipeline to automate an analysis workflow. It was effectiv
101.
by j_bum 1y ago
I’d love to hear how to start today efficiently. Please do share! Sincerely, A true night owl.
102.
by j_bum 1y ago
The search is very impressive. It uses CLIP. So you can search “black cat on blue carpet in the morning” and expect to see a result (if it exists)
103.
by j_bum 1y ago
I haven’t listened to this podcast, but I listened to an excellent RadioLab podcast a while ago on the topic. They ended the podcast by discussing some of the ethics of “fixing” aphantasia, many of which I had never considered. I recall the
104.
by j_bum 1y ago
I’d love to hear the work you’re involved in!
105.
by j_bum 1y ago
This makes me think that for simple things, we need to anti-prompt — tell the model to not overthink things.
106.
by j_bum 1y ago
He would pay to have his videos as ads on other people’s videos. E.g., I’d go to watch a video of SmarterEveryDay, and Tai Lopez would show up as an ad, telling me all about his Lamborghinis and bookshelves of books he’d never read. And peo
107.
by j_bum 1y ago
The sea urchin (#5) is my favorite, I think. The tardigrade is incredible too. Both made me awe at the marvel of biological machinery. Such complicated and sophisticated behavior is occurring all around us, even in the tiniest of organisms.
108.
by j_bum 1y ago
Agreed. This is how the R language allows you to explicitly scope functions from packages. I honestly love that syntax. E.g., `dplyr::filter`, `limma::voom`
109.
by j_bum 1y ago
For what it’s worth, in the iOS App Store, you can scroll down to look at the “In-App Purchases” drop down menu, and all of the prices are shown there. This is true for every app with IAP. It’s how I typically decide if I’ll download an app
110.
by j_bum 1y ago
Incredible list. Thanks for sharing.
111.
by j_bum 1y ago
VSCode is my go to for large text file interaction on macOS. TextEdit may be worth looking into as well? Haven’t tested it for large files before.
112.
by j_bum 1y ago
Did you mean the Search Engine podcast..?
113.
by j_bum 1y ago
I don’t imagine you meant to, but this triggers my LLM sense because of the way Claude Sonnet 4 responds to any critique.
114.
by j_bum 1y ago
Do you have any go-to examples of “facts” that were disproven in this field?
115.
by j_bum 1y ago
The recent betas have been extremely performant for me, especially today’s. Might be worth checking out again.
116.
by j_bum 1y ago
Good to know, I’ll try to just use this a bit more then. I always opt for one of the above modes, with varying degrees of success. Not sure if you tend to edit your posts, but it could be worth clarifying. Btw — my colleagues and I all love
117.
by j_bum 1y ago
Is this the “Web Search”, “Deep Research”, or “Agent Mode” feature of ChatGPT? Navigating their feature set is… fun.
118.
by j_bum 1y ago
I have cut out the vast majority of news and social media since the beginning of 2025. My mental health is noticeably better, and I would readily attribute this to not being tuned in to the ongoings of the globe that I have zero control ove
119.
by j_bum 1y ago
When I was getting my Ph.D., my advisor jokingly told me that his lab has three 8 hour shifts per day, and I could pick two to work. This was never literally practiced. But excessive hours were the norm. And I loved it. It helped me launc
120.
by j_bum 1y ago
I wonder if there is an XKCD number: how many ref outs until you can find an XKCD comic?

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