iskander

38 ms·

361.
by iskander 11y ago
I actually agree with you up until the last sentence. Many researchers and doctors care quite a bit and are excited to finally be moving toward curative treatments (rather than chemo treadmills).
362.
by iskander 11y ago
I wouldn't voluntarily touch K/Q ever again, but if someone else is interested in doing a blog post: try implementing any iterative machine learning algorithms. The separate compilation of primitive operators requires creating man
363.
by iskander 11y ago
1) Aside from significant increase in cost and experiment turn-around time, there's a more basic question: if you don't use a replicable and scalable model of the disease, how do you induce the cancer you're interested in st
364.
by iskander 11y ago
>If you made me cancer dictator with an NIH budget and an ability to set the rules I could provide very rapid progress. What would you change?
365.
by iskander 11y ago
This works particularly well for cancers with recurring mutational patterns (like KRAS mutations in pancreatic cancer), since that lets you affordably do ultra-deep sequencing of small regions of the genome. If you had to deep (>5000x co
366.
by iskander 11y ago
One idea: if you have a biomarker you can track via CTCs or ctDNA, then you could watch the rate at which that marker's availability increases. The PSA doubling time for indolent prostate cancers can often be measured in years, whereas
367.
by iskander 11y ago
That's been true as long as treatments for cancer have ever been researched (reaching back to the 1800s). Only recently have immunotherapies started yielding significant clinical results for common cancer types. I think the change in e
368.
by iskander 11y ago
The biggest difference, as of 2015, is that we now have an extremely promising and more coherent research direction in the form of immunotherapy: (1) activating and disinhibiting adaptive immune cells (2) engineering highly active immune ce
369.
by iskander 11y ago
Thanks!
370.
by iskander 11y ago
It's amazing to read an article about cancer drug development which doesn't talk about the successful immunotherapies. I know that checkpoint blockade and cellular therapies weren't as widely known in 2010, but it shows how
371.
by iskander 11y ago
I briefly worked with K and Q while doing research on high-level numerical computing. I found their claimed efficiency to be severely exaggerated. K is a very naively implemented array-oriented language and I found it to be slower than Matl
372.
by iskander 11y ago
The article is paywalled for me, is there an alternative link?
373.
by iskander 11y ago
How does Chariot compared with [Via]( http://ridewithvia.com/ ) in NYC?
374.
by iskander 11y ago
>cripple may be insensitive, use person with a limp instead Hard to tell if this project is parody or authentic.
375.
by iskander 11y ago
Probably the most important result: >There is one S-PRNG construction where we have not been able to find any fault, namely the hash based generator of Claessen and Pałka (2013a). In particular, the generator was subject to the test meth
376.
by iskander 11y ago
My small sample size of experience with the FDA: they seem to be very receptive to novel therapies for terminal illness and it's surprisingly straight-forward to get a Phase I trial approved. There's no static rule uniformly enfor
377.
by iskander 11y ago
>Occupy had to protest confusing stuff. I agree that a lot of the details of the financial system fly over society's collective heads, but I think the impunity of white-collar bad actors was a very concrete non-confusing source of o
378.
by iskander 11y ago
Missed a few of the ones I tried: "zina" "eir" "khuee" "popa"
379.
by iskander 11y ago
It's great, I'm really happy to be learning so much new and different material and equally happy I didn't go to Silicon Valley. I think I had previously carved a little niche for myself where I felt like an expert and didn&#x
380.
by iskander 11y ago
I haven't left software behind but did pivot toward working in a biomedical lab and investing a lot of my time and effort in learning biology and prioritizing science over engineering. The reason for moving away from software was that
381.
by iskander 11y ago
The highest rate of Neanderthal admixture is in East Asians, but there is also a non-trivial rate (2-6%) in most Europeans. The admixture in sub-Saharan Africans is much lower, which creates a risk of any discussion of positive Neanderthal
382.
by iskander 11y ago
>Actually the house was rented for the purpose of hosting the program, not the other way around. From the CFP I got the impression that the residency is hosted in the same place you all are currently living: >live for four months in a
383.
by iskander 11y ago
It seems a little unusual to see a "residency" which makes you pay for housing ($2400 / month). Is it unfair to assume they're having trouble paying rent at the Topos house?
384.
by iskander 11y ago
One of the many sad things in this story is that Stephanie Lee was given false hope by overly enthusiastic technologists. Since YC is now funding biomedical startups, this will hopefully serve as a warning to others who find it easier to so
385.
The Death of Patient Zero(esquire.com)
73 points by iskander 11y ago|12 comments
386.
by iskander 11y ago
>Folks who can’t afford to live in those places don’t get to take advantage of those labor markets. The demand to live in these places is soaring, but the desire among incumbents to accommodate newcomers is low. Hence NIMBYism, high hous
387.
by iskander 11y ago
Is Watson a single fixed codebase or just a branding of multiple loosely related IBM research projects?
388.
by iskander 11y ago
>Spark takes a Scala AST tree and computes a plan on it in order to distribute it to a cluster of possibly thousands of nodes Unless Spark has changed dramatically in the year since I used it, that's not really how it works. You laz
389.
by iskander 11y ago
If you combine this with [modular implicits]( http://www.meetup.com/NYC-OCaml/events/222026251/ ), which are hopefully going to be added to OCaml soon, then you'll get something which is nearly as syntacti
390.
by iskander 11y ago
What else do you use to train the network?

More ›