iskander

31 ms·

301.
by iskander 8y ago
It's worth reading the article, it's about an interesting study in lab mice.
302.
by iskander 8y ago
No opinions on how anyone should update firmware but I just wanted to chime in that I bought a fairly expensive System76 laptop in 2011 and was very disappointed with how rough & clunky it was.
303.
by iskander 9y ago
I deleted Uber during that campaign and so did at least a dozen people that I know. I don't know the exact numbers, but I think Lyft's market share roughly doubled within several months. How did "the market" not notice?
304.
by iskander 9y ago
>And I'm pretty confident the majority of experiments are using sample sizes larger than 12. It definitely varies by field, testing 3 doses and a negative control with 3x replication would be a pretty good experiment for testing a d
305.
by iskander 9y ago
Science often works with data set sizes that make the standard ML approach unworkable (e.g. 12 measurements which took months and thousands of dollars to make)
306.
by iskander 9y ago
This article is more religious than technical. You're meant to be inspired by the elegance of it all, not necessarily to understand much about the use of monads in practice.
307.
by iskander 9y ago
>Mutants are actually quite common in the animal kingdom but usually die out Naw, every person is likely to carry at least one de novo mutation in their genome. Mutations happen constantly, they're just usually unremarkable.
308.
by iskander 9y ago
"Not as bad as WWII" isn't much of a standard for world peace. If you total up casualties from the ongoing conflicts in Syria, Yemen, Libya, Iraq, Afghanistan, and Somalia then you might be surprised at just how many violent
309.
by iskander 9y ago
I'm really glad the treatment has worked for you! Were you treated in the context of a trial or was pembro used as standard of care?
310.
by iskander 9y ago
I'm relatively new to cancer research (start 4 years ago), so I might be ignorant of significant advances. Did adjuvant chemo improve long term survival for any disseminated cancers?
311.
by iskander 9y ago
Were metastatic melanoma and NSCLC considered "easy" before immunotherapy? My understanding is that they were near certain death sentences. I think that the progress so far certainly looks revolutionary compared with the previous
312.
by iskander 9y ago
The premise of this blog post is flawed. Despite the madness of the pharmaceutical industry, we are currently experiencing a revolutionary improvement in treatment. Essentially nothing interesting, from the patient's perspective, happe
313.
by iskander 9y ago
>Targeted chemotherapy consists of drugs that are meant to specifically kill cancer cells and not healthy cells. Putting immunotherapies (like nivolumab) under this category I think will only confuse the reader about the state (and direc
314.
by iskander 9y ago
>Sure is a good No True Scotsman you've got there. And I'm not even sure you'd be right ignoring that; recall that sports like boxing and MMA separate people into weight classes that are ten pounds wide. In other words, th
315.
by iskander 9y ago
There are several such databases, the largest of which is TCGA ( https://cancergenome.nih.gov/ ). They have sequenced >32k patients across several dozen cancer types. Here's their getting started guide: https:/&
316.
by iskander 9y ago
"Hashem vayikach" is gibberish in modern Hebrew though. You'd have to change it to something like "lakach". In modern Hebrew it would be something like "Hashem lakach ha'adam v'sam oto b'gan Eden
317.
by iskander 9y ago
>A non-fluent Hebrew speaker would not even be able to tell the difference between the modern and biblical. As a non-fluent Hebrew speaker who took ~10 years of Hebrew classes as a kid, this seems totally untrue. Biblical Hebrew is inten
318.
by iskander 9y ago
Having experienced the weakness of the scientific institutions in several low tax states, I wouldn't expect this effect to be very strong.
319.
by iskander 9y ago
Are those experiences on recent chemistries/flow cells? My first library prep gave me ~4 gigabases on a R7.4 flow cell and that was pretty low compared with everyone else in the workshop. Also, which library prep are you using? I think
320.
by iskander 9y ago
Nanopore sequencing is definitely "already here" in the sense that they're selling a lot of flow cells and people are doing useful research with ONT instruments but it's also a niche technology compared with Illumina.
321.
by iskander 9y ago
I've only sequenced a few samples on a MinION. The dominant error seemed to be miscounting the length of a homopolymer stretch (e.g. CCC->CCCCC) but the substitution error rate was also clearly worse than Illumina. I've gotten
322.
by iskander 9y ago
They currently specialize in different things. The larger Illumina instruments have a huge up-front cost (~$1M), tremendous throughput, low cost per base, short reads, <1% base error, and significant latency between starting sample prep
323.
by iskander 9y ago
It's strange that this article ends as an advertisement for PacBio sequencing (which can ~50k-60k base reads) but makes no mention of Oxford Nanopore (which has gotten megabase reads and keeps improving). Single molecule nanopore seque
324.
by iskander 9y ago
In biomedicine, at least, I'd really need some examples. Every break-through I can think of came from publicly funded research, which then gets turned into a product.
325.
by iskander 9y ago
Have you ever worked in a research capacity at either an academic or for-profit institution? My experience has been that private for-profit entities are good at scale and terrible at discovering new ideas.
326.
by iskander 9y ago
Immunotherapy research uses cell lines as much as every other branch of microbiology. For example, the T2 cell line is lacking in a peptide transport protein called TAP, which makes it handy for studying the immune recognition of arbitrary
327.
by iskander 9y ago
The response times on approval can be pretty terrible and you get peppered with a lot of dumb requests by reviewers who don't actually understand the material. (I grew up around my parents' vocational school, board of education in
328.
by iskander 9y ago
Dog boarding, on the other hand, is pretty irregular. So rather than Uber I think the correct analogy should be AirBnB.
329.
by iskander 9y ago
I use Rover quite a bit. I have some "usual suspects" for dog walking / dog sitting but they're not always available.
330.
by iskander 9y ago
There's also a much more conservative and narrowly scoped effort to help late stager cancer patients make their own therapeutic peptide vaccines: http://alunglife.com/goal-cure-cancer-method/

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