inasio

29 ms·

391.
by inasio 7y ago
All viral diseases will have simple and effective therapies (one pill a day kind of thing). Eradication of most viral epidemics will be well on its way
392.
by inasio 7y ago
From a purely epidemic control point of view the most rational path is to test this population as often as possible (every 6 months or less) and treat them immediately if testing positive. If you find people that reinfect rather than a bad
393.
by inasio 7y ago
The two key groups in western countries are baby-boomers (likely acquired the infection from dentists/doctors reusing needles), and intravenous drug users. The best bang for your buck is in testing and treating this last population, bu
394.
by inasio 7y ago
I worked for 5 years doing epidemic modeling for HCV, from right around when the first generation of the modern treatments became available (Sofosbuvir, etc). When I started working it was immediately clear that Sofosbuvir et al were a tota
395.
by inasio 7y ago
It cost exactly 11 billion for Gilead to "develop" Sofosbuvir (they bought Pharmasset who discovered the drug [1]) [1] https://en.wikipedia.org/wiki/Sofosbuvir#History
396.
by inasio 7y ago
No, Gilead didn't develop Harvoni/Sovaldi/Sofosbuvir, it was originally discovered by Pharmasset, and then Gilead bought them for 11 billion [1] [1] https://en.wikipedia.org/wiki/Sofosbuvir#History
397.
by inasio 7y ago
At least a couple of years ago there were so many treatments on the pipeline that it was probably doable to find a phase 3 trial that would take you in.
398.
by inasio 7y ago
I used to do research on HCV. HCV was curable for at least 10 years prior to Sovaldi, the issue was that the Ribavarin and peg-interferon treatment typically took 48 weeks, had a cure rate around 50% at best if you had the right HCV genotyp
399.
by inasio 7y ago
I used to do HCV research in British Columbia. Something that might be useful for you if you haven't yet started treatment is to see if you qualify for a settlement. In BC in particular there was a class action lawsuit the compensated
400.
by inasio 9y ago
Per dollar of CPU, CPU + power, CPU + motherboard, TCO?
401.
by inasio 9y ago
In the US efficacy is typically measured through estimates of DALYs (disability-adjusted life years). Following WHO guidelines, cost of an intervention (or drug) up to three times the national per-capita GPD (~3x50K in the US) is considered