greygoo222

8 ms·

61.
by greygoo222 8mo ago
You're incredibly wrong. You also cited my own comment at me. The problem of high interstitial pressure (not blood pressure) interfering with drug delivery in tumors is basic cancer biology. If you don't believe me, here's: A
62.
by greygoo222 8mo ago
They're not pointing out something the researchers missed, they're pointing out something the people in this thread confidently hyping the results are missing. I'm certain the researchers are familiar with the limitations of
63.
by greygoo222 8mo ago
This is kind of true but misses the bigger picture. We have developed many drug options more targeted than traditional chemotherapy, famously Gleevec for example. The question isn't whether we've found one that could work at all,
64.
by greygoo222 8mo ago
Both patient participation in clinical trials and compassionate use of experimental treatments are fairly common for cancer patients, with various accessibility barriers. (One issue with the latter, for example, is that the incentives aren&
65.
by greygoo222 8mo ago
These are all correct observations about the limitations of xenografted mouse models.
66.
by greygoo222 8mo ago
Xenografted human tumors in mice != human cancer. The support structure of the tumor (tumor microenvironment) differs between model mice and humans, cells derived from human cancer that can be cultivated in a lab and xenografted differ from
67.
by greygoo222 8mo ago
Your testicles, empirically, shrink when it gets cold. Do you think measuring their shadow is an acceptable substitute for a thermometer?
68.
by greygoo222 8mo ago
Sigh. Sure, if you had a gun to your head and you knew nothing else, it would be better to guess that a given population (hunter-gatherers) with low rates of some illnesses (T2D, HBP) also had low rates of another illness (CRC) than the rev
69.
by greygoo222 8mo ago
C'mon, I already said that, that was half of my comment!
70.
by greygoo222 8mo ago
I won't bother checking or disputing the accuracy of your factual claims, because it does not matter. Colorectal cancer is not the same thing as high blood pressure, or type 2 diabetes, or any other cancer that isn't colorectal ca
71.
by greygoo222 8mo ago
You shouldn't so offhandedly assume a hunter-gatherer lifestyle couldn't lead to issues like increased risk of CRC, or that activities which lead to increased risk of CRC couldn't be what hunter-gatherers did. Evolution is ne
72.
by greygoo222 8mo ago
This mostly can't explain the fact that mortality is also rising in under 50s. It is true mortality is rising less than incident, and that a small proportion instances of mortality could be deaths related to reasonable risks taken on f
73.
by greygoo222 8mo ago
Let me try this again. High fertility is the rule, not the exception, of human behavior. Human population has, give or take, consistently increased since the invention of agriculture. Modern trends of society-wide low fertility are an unusu
74.
by greygoo222 8mo ago
I guarantee you I've spent more time thinking about this than you have. Massive decreases in population change culture. The Western cultural context we have today won't just magically persist, converting new people, until we run o
75.
by greygoo222 8mo ago
I was wondering which pet issue you were a doomer about. Fertility is the most ridiculous of them all. There is no plausible mechanism by which low fertility rates could lead to extinction, and if you think there is you don't understan
76.
by greygoo222 8mo ago
I am very aware of the history of amphetamine use in the US. I think widespread access to amphetamines was mostly good (and widespread access to benzos was mostly bad).
77.
by greygoo222 8mo ago
It's crazy that you accuse the person you're replying to of being lucky, when your comment is the epitome of privilege. Since the year 2000, child mortality rates declined over 2x in Africa and Asia. That is millions of children w
78.
by greygoo222 8mo ago
This can't explain the data in the article, such as the fact that people underestimate the rate at which other survey responders will report being happy.
79.
by greygoo222 8mo ago
There are many more undeniable mathematically-confirmable trends that bode well: life expectancy, poverty, homicide rates, etc. Most important things are getting better.
80.
by greygoo222 8mo ago
I find it more likely that we'll recognize the social benefits of widespread stimulant prescriptions, and make them easier to get.
81.
by greygoo222 8mo ago
You can most likely afford to buy a viable homestead in a rural area if you wanted to. Your problem isn't that you can't afford a house, it's that you can't afford a house in San Francisco. I sincerely doubt that you can
82.
by greygoo222 8mo ago
The trouble with the dementia prevention claim is that while the retrospective studies are promising, none of the RCTs really show results. You can argue this is because the RCTs don't dose enough nicotine early enough to matter, and t
83.
by greygoo222 8mo ago
GLP-1s are the greatest medical innovation of the past decade. Top three, at least, mRNA might give them a run for their money. There are known side effects, mostly gastrointestinal issues, and they don't work for everyone. That being
84.
by greygoo222 8mo ago
No it isn't. Every neurotransmitter is involved with every complex phenomenon.
85.
by greygoo222 8mo ago
Nicotine pouches (or even vaping) are astronomically less harmful than cigarettes and still work as appetite suppressors. As a bonus they are more convenient to use in public. Smokers should consider considering switching instead of quittin
86.
by greygoo222 8mo ago
I guarantee you approximately nothing on LiveLeak was consensual. Consensual cartel executions? Men are more likely to be victims of violent crime than women. Adjust according to what?
87.
by greygoo222 8mo ago
Lots of people just aren't that bothered by gore videos and they are well-adjusted members of society, I dunno what to tell you.
88.
by greygoo222 8mo ago
Livestock, staple crops, and pollinating insects cope pretty well over a wide variety of temperatures. Some specific crops don't, but that's not a problem as long as changes are predicted.
89.
by greygoo222 9mo ago
I feel like I'm taking crazy pills here. Am I just too old? What do you mean, people on this forum have no intuition about what watching gore videos online is like? About watching hours of ordinary porn (as the article also mentioned)?
90.
by greygoo222 9mo ago
This is utterly ridiculous. The majority of teens I knew watched a few hours of LiveLeak at some point and turned out fine.

More ›