glp1guide

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31.
by glp1guide 1y ago
We think obesity is basically going to be gone in <7 years. GLP1s don't work for everyone, and the side effects can be severe, but this these drugs are basically safe, and incredibly effective. This is going to accelerate when every
32.
by glp1guide 1y ago
Note that these results probably apply to Mounjaro/Zepbound as well, because they are the most effective GLP1s on the market right now: https://glp1.guide/content/semaglutide-vs-tirzepatide-clinic... My bet is on
33.
by glp1guide 1y ago
Yes, we should, and eventually those who need to will be. Pill forms of the drug are currently uninspiring (see: Rybelsus), but as different formulations (triple agonists, etc) that are more effective also get their own pill forms, it is
34.
by glp1guide 1y ago
Retatrutide looks to be very effective, but it's not possible to get legally/safely at this point. TONS of experience/knowledge in the r/retatrutide subreddit though, a lot of pretty conscientious consumers in there th
35.
by glp1guide 1y ago
Ah -- the linked research trial contains evidence that it is not the best, Tirzepatide is more effective. Unless you mean that Semaglutide worked best for you , right now the research points at Tirzepatide being most effective for weight
36.
by glp1guide 1y ago
Oh also, the side-effect category is a good place to watch: https://glp1.guide/tag/category-side-effects/ https://glp1.guide/tag/category-risks/ I try to tag all the new news of negative
37.
by glp1guide 1y ago
Let me try again: 1. People do not stay on GLP1s for long, despite how effective they are 2. People often rebound harder from other forms of weight loss (dieting, temporary lifestyle changes, etc) 3. GLP1 reduces a LOT of health risks linke
38.
by glp1guide 1y ago
It varies case by case, but just want to point out that the research agrees with you here, Tirzepatide is more effective than Sema!
39.
by glp1guide 1y ago
Liraglutide is now available as a generic, but it is the least effective of the big 3 (Semaglutide, Tirzepatide, Liraglutide): Basically, Tirz > Sema > Lira https://glp1.guide/content/semaglutide-vs-tirzepatide-cl
40.
by glp1guide 1y ago
> For semaglutide, the newest and most potent GLP1. Tirzepatide is the most potent GLP1 https://glp1.guide/content/semaglutide-vs-tirzepatide-clinic...
41.
by glp1guide 1y ago
That's an insane cost reduction -- $250/month is a common gray market price in the US.
42.
by glp1guide 1y ago
Tried to list them all here: https://glp1.guide/content/are-glp1-side-effects-all-the-sam... It was a while ago, but IMO the list still plays
43.
by glp1guide 1y ago
Note that right now there's a problem with people staying on GLP1s[0] so it's not quite clear how this could go any other way. Considering the rate of rebound from other lifestyle methods, GLP1 is among the most effective altern
44.
by glp1guide 1y ago
Also relevant, compounders are being sued by Eli Lilly right now. The compounding loophole is being welded shut: https://glp1.guide/content/eli-lilly-suing-glp1-compounders-... Only a partial patent expiry for Semaglu
45.
by glp1guide 1y ago
This is certainly a problem, but there just isn't much that many can do about the laws as they are written (and the whole incentives of the pharmaceutical industry as we know it). That said, there is some hope on the horizon, some pate
46.
by glp1guide 2y ago
Absolutely! Timing on that is not so great though: https://glp1.guide/content/patent-expirations-for-glp1-recep... Again this is not great news but if you zoom out it’s amazing that obesity might be a solved problem ba
47.
by glp1guide 2y ago
Woops, last link is wrong: https://glp1.guide/content/patent-expirations-for-glp1-recep...
48.
by glp1guide 2y ago
Sorry a bit late here, but both Tirzepatide and Semaglutide are off the shortage list, and the promise to not seek legal action that is currently allowing some compounders to operate freely will likely end sometime soon. Literally, the only
49.
by glp1guide 2y ago
> Admittedly if there were a GLP1 for procrastination, I'd be on that stuff like a shot... This might be my biggest unknown with GLP1s, how does it affect people with reward system issues — it could dramatically worsen a procrastina
50.
by glp1guide 2y ago
No it hasn’t— its well researched and the short to mid term (ish) side effects are well known: https://glp1.guide/tag/category-side-effects/
51.
by glp1guide 2y ago
I think this is the appropriate response — it’s clear that lack of appetite control is driving purchases a nontrivial amount of the time for junk foods — companies that depend on that revenue have never really had a challenge until now
52.
by glp1guide 2y ago
Yeah unfortunately that’s about to come to an abrupt end
53.
by glp1guide 2y ago
Incredibly excited about these drugs (like everyone else) and have been looking into them for a bit. A few notes: - Semaglutide just came off the shortage list [0], companies won’t be able to compound it for long - generic Liraglutide exist
54.
by glp1guide 2y ago
Been writing about this a ton as well -- these drugs are quite possibly the closest things to actual wonder drugs I've ever seen. One thing that was really interesting was looking at how the side effects differed[0]. It's rare t
55.
by glp1guide 2y ago
Well of course, the problem is in the mind. As most disorders are. That said, I wonder if people with those kinds of eating disorders also suffer from the "food noise" phenomenon.
56.
by glp1guide 2y ago
Super tired of seeing this argument. Most people who get on GLP1 Receptor Agonists keep their weight gains. If someone told you there was a consistent, well researched and studied way to lose 5% of your body weight, would you take it? Of
57.
by glp1guide 2y ago
Welp, water is wet. It won't be up to Novo Nordisk to reduce the cost of GLP1 RAs -- it will be up to other entrants into the market (that said, there are worryingly few), and huge companies taking up manufacturing of GLP1s and similar
58.
by glp1guide 2y ago
While metformin is cheaper, I find that only fairly wealthy "longevity" maximizers have heard of it. Also, it's far less effective than GLP1 RAs at weight loss, which is what most people want.
59.
by glp1guide 2y ago
A bit late here, but vivid dreaming... that's absolutely a new thing I haven't seen before. Interesting, this reminds me of the effects of coming off of THC, I wonder if there's some relation.
60.
by glp1guide 2y ago
Another bullet point in the list of benefits for GLP1 RAs -- it's amazing all the areas that it seems to touch. I've been on the lookout personally for more negative side effects (it's almost suspicious how little there are,

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