flobosg

68 ms·

961.
by flobosg 6y ago
Yeah, the Grammar of Graphics syntax can feel a bit awkward at first, but once it clicks it makes a lot of sense.
962.
by flobosg 6y ago
It’s also a term used in biology: https://en.wikipedia.org/wiki/Polymorphism#Biology
963.
by flobosg 6y ago
I’m sorry to read of Bertrand’s passing. I’ve been following your writing for a while, including your son’s story, and I find nothing short of admirable the lengths that you and your family have gone to ensure that he was loved and cared fo
964.
by flobosg 6y ago
Pandemrix, an influenza vaccine, was associated to an increased risk of narcolepsy for up to two years after administration.
965.
by flobosg 6y ago
> Moderna's vaccine, conversely, was grown in HEK 293 Do you have a link to confirm that? I thought that Pfizer/BioNTech as well as Moderna used HEK cells solely for testing.
966.
by flobosg 6y ago
The dagger (the typographic name of that symbol) is usually employed as a footnote indicator if an asterisk is already present.
967.
by flobosg 6y ago
Related: The Cutting Room Floor ( https://tcrf.net/ ) documents unused content from released and unreleased video games.
968.
by flobosg 6y ago
I’ve been following Hundred Rabbits’ Rekka[1] and Devine[2] for a while. Their sites are full of interesting tidbits on different topics and projects. If you liked the article I recommend having a look at them. [1]: https://kokor
969.
by flobosg 6y ago
To put it into context: https://en.wikipedia.org/wiki/Endogenous_viral_element
970.
by flobosg 6y ago
> Unsubstantiated Not really: https://www.liebertpub.com/doi/10.1089/088922299309810
971.
by flobosg 6y ago
I didn’t know of DNA Chisel ( https://edinburgh-genome-foundry.github.io/DnaChisel/ ) until now. Thanks for the heads-up!
972.
by flobosg 6y ago
More or less so. Roughly speaking, the effectiveness of the vaccine should be the same as long as the shape of the spike protein doesn’t change. The most important mutation in the new VOC 202012/01 variant (N501T) translates to tighter
973.
by flobosg 6y ago
Spike proteins in coronaviruses are present in two structurally distinct conformations: pre- and postfusion. The conformational switch between them promotes the viral fusion to the host cell. To maximize the effectiveness of the vaccine, it
974.
by flobosg 6y ago
> You heard it here first. https://news.ycombinator.com/item?id=25596401 ;-)
975.
by flobosg 6y ago
Related paper: https://www.pnas.org/content/114/35/E7348
976.
by flobosg 6y ago
> You can submit RNA sequences to this server of the Institute for Theoretical Chemistry at the University of Vienna and it will fold RNA for you. This is a very advanced server that does meticulous calculations. ViennaRNA is also availa
977.
by flobosg 6y ago
There seems to be an early-onset but also long-standing effect, maybe due to circulating antibodies inducing the autoimmune response over time.
978.
by flobosg 6y ago
Thank you for the links! Here’s a review about autoimmunity in COVID-19: https://www.sciencedirect.com/science/article/pii/S089684112... > There is a study[0] showing cross-reactivity between SARS-CoV-2 an
979.
by flobosg 6y ago
> (...) but in my mind the spike proteins that are generated by an actual infection don't typically leave the cytoplasm detached from the rest of the virus. If the virus is destroyed and released into the extracellular environment,
980.
by flobosg 6y ago
There will be a post-approval Phase IV surveillance stage to check for rare or long-term adverse effects. > I recall a famous drug that was given in the 70s and it produced birth malformations. You’re probably referring to thalidomide. &
981.
by flobosg 6y ago
> Tissue cross-reactivity assay is a standard method based on immunohistochemistry, required prior to phase I human studies for therapeutic antibodies. ― https://en.wikipedia.org/wiki/Cross-reactivity#Applications_...
982.
by flobosg 6y ago
Glad to see Torres del Paine there. I did the W Trek a year ago and can’t recommend it enough. Absolutely breathtaking. Also recommended: Craig Mod’s Ridgeline newsletter about walking in Japan[1]. He recently completed the Tōkaidō road. [1
983.
by flobosg 6y ago
I should have cleared that up. Normally Ψ would stand for pseudouridine, but the vaccine has a further modified base, 1-methylpseudouridine.
984.
by flobosg 6y ago
Yes. Codon optimization is a routine procedure when designing genes and is mentioned in the article. Methionine and tryptophan, however, cannot be optimized since they only have one codon each.
985.
by flobosg 6y ago
Related post, from a few weeks ago: https://news.ycombinator.com/item?id=25270762
986.
by flobosg 6y ago
> cells can't make Ψ Pseudouridine is the most common RNA modification in cells, actually. They produce it all the time. > and probaby Ψ is not super durable as a chemical. Quite the opposite. Pseudouridine usually increases the
987.
by flobosg 6y ago
Such a great talk. The storytelling here is top-notch. I’m glad you reminded me of it.
988.
by flobosg 6y ago
That “I solved the mystery here” part made me laugh so hard. Thank you for sharing!
989.
by flobosg 6y ago
No. Quod Libet is GTK-based.
990.
by flobosg 6y ago
This is a nice and comprehensive article about the typography of NGE: https://fontsinuse.com/uses/28760/neon-genesis-evangelion

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