flobosg

4 ms·

31.
by flobosg 4mo ago
> that structure is as/more important than sequence? Structure is determined by sequence, so they are equally important. Structure is more conserved than sequence, mainly due to the physicochemical constraints that govern protein
32.
by flobosg 4mo ago
My PhD thesis addressed a similar question. I did a survey of sub-domain sized fragments shared between different protein folds. It turns out that there are plenty, even among folds considered evolutionarily distant.
33.
by flobosg 4mo ago
This reminds me of structural studies in proteins encoded by de novo genes in eukaryotes. They are usually either intrinsically disordered or adopt a molten-globule-like state.
34.
by flobosg 4mo ago
> Natural selection has no analogy with any aspect of human behavior, However, if one wanted to play with a comparision, one would have to say natural selection does not work as an engineer works. It works like a tinkerer - a tinkerer wh
35.
by flobosg 4mo ago
Not sure if I understand your reply. Currently, the Sequoia beta channel is only getting security patches.
36.
by flobosg 4mo ago
> switch to the Sequoia public beta channel! https://news.ycombinator.com/item?id=47198977#47202707
37.
by flobosg 4mo ago
One of the things that helped me is Brick ( https://getbrick.com/ ), which blocks and unblocks apps using a small device with an NFC tag.
38.
by flobosg 4mo ago
I was going to say the same! You can also check the recipe card here: https://www.cookingforengineers.com/recipe/19/Erics-Chocolat...
39.
by flobosg 4mo ago
He’s talking about the past (“For a while, …”). Up to early 2010s, I would say.
40.
by flobosg 4mo ago
A quick search gave me for example this one: https://genome.cshlp.org/content/26/1/36
41.
by flobosg 4mo ago
> I'm not familiar with Margaret Oakley Dayhoff Then you’re one of today’s lucky 10,000. Any time!
42.
by flobosg 4mo ago
Or rather Margaret: https://en.wikipedia.org/wiki/Margaret_Oakley_Dayhoff
43.
by flobosg 4mo ago
The Red Bull Music Academy web series Diggin’ In The Carts has an episode featuring Koshiro: https://www.redbull.tv/en/page/page:rrn:content:episode-vide...
44.
by flobosg 5mo ago
My favorite antibiotic is fire.
45.
by flobosg 5mo ago
“No, John. You are the goblins.” ( https://doom.fandom.com/wiki/Repercussions_of_Evil#The_Story... )
46.
by flobosg 5mo ago
If you liked David Goodsell’s illustration you can find more of his work at https://ccsb.scripps.edu/goodsell/ . I’m a huge fan.
47.
by flobosg 5mo ago
How Perl Saved the Human Genome Project : https://bioperl.org/articles/How_Perl_saved_human_genome.htm...
48.
by flobosg 5mo ago
Yes, he is! (Which explains other of his mangas, Akagi ): > He has been playing mahjong since junior high school days, and admitted that though he has rarely lost a game when he was in school, his current level of ability is average. Ac
49.
by flobosg 5mo ago
In the Kaiji manga, the “Minefield Mahjong” arc uses a variation of Japanese Mahjong. It can be read without knowing the general rules (as I did), but I guess they make some of the scenes more understandable and/or impactful. Maybe I
50.
by flobosg 5mo ago
(2012)
51.
by flobosg 6mo ago
Teenage Engineering designed the Playdate, in case you didn’t know: https://teenage.engineering/designs/playdate
52.
by flobosg 6mo ago
Tereré is also a milder alternative: https://en.wikipedia.org/wiki/Terer%C3%A9
53.
by flobosg 6mo ago
> They have made a sugar free version now as well, but that not as cool as making your own That version (Club Mate Zero) is hard to get in supermarkets as well, at least where I’m living in Germany. I usually order it online.
54.
by flobosg 6mo ago
Club Mate has a different taste than traditionally brewed yerba mate. It’s carbonated as well.
55.
by flobosg 6mo ago
> mate tea as tea sachets Look for “mate cocido”. La Tranquera is the brand I use.
56.
by flobosg 6mo ago
See https://hn.algolia.com/?dateRange=all&page=0&prefix=false&qu... as well.
57.
by flobosg 6mo ago
Here are plenty of small apps developed with LÖVE: https://git.sr.ht/~akkartik , see also https://akkartik.name/
58.
by flobosg 7mo ago
Also King Gizzard & the Lizard Wizard – Flying Microtonal Banana .
59.
by flobosg 7mo ago
Same here. I think no site brings me less joy than LinkedIn. I find broetry particularly tiring to read.
60.
by flobosg 7mo ago
The header illustration brought to my mind, for some reason, the tomato bushy stunt virus depiction by the late Irving Geis: https://pdb101.rcsb.org/sci-art/geis-archive/gallery/geis-05...

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