flobosg

25 ms·

421.
by flobosg 3y ago
> is trying too hard Maybe, but still a valid pronominal verb.
422.
by flobosg 3y ago
“Despidióse excesivamente antes ”?
423.
by flobosg 3y ago
> other selector genes such as H63D and C282Y A nitpick: Those are not genes, but mutations, probably describing variants of the HFE gene (according to a quick search).
424.
by flobosg 3y ago
Related: I wrote Task Manager and I just remembered something – https://news.ycombinator.com/item?id=23304536
425.
by flobosg 3y ago
Roland the drummer really does a great job there.
426.
by flobosg 3y ago
I’m a big fan of his music and his writing. Check out his cooking blog (inactive since 2013): https://web.archive.org/web/20190227102420/http://mariobatal...
427.
by flobosg 3y ago
Additional links: * What to Do Before You Die: A Tech Checklist – https://archive.is/6vjqQ * Cheat Sheet For If I'm Gone – https://archive.is/lnWX6 – https://github.com/christophercalm&#
428.
by flobosg 3y ago
Chemicals like… neurotransmitters?
429.
by flobosg 3y ago
Virtual screening[1] is a computational technique where you take an experimentally resolved structure of a protein (PCNA in this case) and sequentially dock a large amount of different compounds to see which ones of them bind favorably to t
430.
by flobosg 3y ago
In 2018, at the Roadburn festival, I got the chance to see them play their single-song, 80+ minute album “Mirror Reaper”[1] live. It was quite an experience; at some points both the band and the audience were so quiet that you could have he
431.
by flobosg 3y ago
Martin Shkreli (yes, that Martin Shkreli) is currently running a virtual screen for additional PCNA inhibitors: https://twitter.com/wagieeacc/status/1687137621699436552
432.
by flobosg 3y ago
The compound might have additional mutagenic mechanisms apart from the described PCNA interaction: it could cause direct chemical modifications to DNA, act as an intercalating agent that disrupts DNA replication and/or transcription, e
433.
by flobosg 3y ago
Thanks for pointing it out. The Wikipedia article mentions that as well, along with some other examples: > Some authors have criticized the rule of five for the implicit assumption that passive diffusion is the only important mechanism f
434.
by flobosg 3y ago
You’re in for a treat! Check out his “Things I Won't Work With” series.
435.
by flobosg 3y ago
Right! I forgot about good ol’ Lipinski: https://en.wikipedia.org/wiki/Lipinski%27s_rule_of_five
436.
by flobosg 3y ago
Not a medical chemist, but I noticed that three AOH1996 molecules are binding to PCNA. Would it make sense to chain together three AOH1996 molecules with flexible linkers for, I don't know, increased specificity or something like that?
437.
by flobosg 3y ago
Somewhat related – This comment from a few months ago about stitching images of passing trains: https://news.ycombinator.com/item?id=35738987
438.
by flobosg 3y ago
No, I use mostly this function, based on bc: https://github.com/adamrights/settings/blob/f0337925391b5ea0... I am currently trying, however, to fix a broken TI-84 Plus I found on the street.
439.
by flobosg 3y ago
In Chile, El Niño is mostly associated to increased rainfall, though.
440.
by flobosg 3y ago
> 38.7C at Vicuña and Chiguinto hottest winter day for Chile;for Coquimbo even an all time high for any month. > Remember:It's winter... — https://twitter.com/extremetemps/status/1686535219350806528
441.
by flobosg 3y ago
I went to one of their concerts during the “Infest the Rats’ Nest” tour. It was… wilder than expected. (In a good way!)
442.
by flobosg 3y ago
The “desert island machine” concept brings to my mind this incredible talk from David Beazley: https://www.youtube.com/watch?v=RZ4Sn-Y7AP8
443.
by flobosg 3y ago
This reminded me of an old post by a bioinformatician: “Some reflections on programming in D, and why it kicks serious ass over C++, leaving it dead and broken on the sidewalk” – https://boscoh.com/programming/some-refl
444.
by flobosg 3y ago
I have been a huge fan of him since his “Not Exactly Rocket Science” days.
445.
Getting Proteins to Crystallize(science.org)
3 points by flobosg 3y ago|0 comments
446.
by flobosg 3y ago
Looks great! It’s giving me some Sun Gallant Demi vibes ( https://i.stack.imgur.com/g1qkf.png ), which is one of my favorite terminal fonts.
447.
Protein Design the AI Way(science.org)
1 points by flobosg 3y ago|0 comments
448.
Longer Life, at a Cost(science.org)
1 points by flobosg 3y ago|0 comments
449.
by flobosg 3y ago
Follow-up study tracking the evolution of this minimal cell: https://www.nature.com/articles/s41586-023-06288-x
450.
by flobosg 3y ago
A paper tracking the evolution of this minimal cell over two thousand generations has just been published: https://www.nature.com/articles/s41586-023-06288-x

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