et2o

42 ms·

451.
by et2o 8y ago
The incidence of reflexively negative takes has increased the last few months on HN.
452.
by et2o 8y ago
Why so negative?
453.
by et2o 8y ago
You basically can’t use HGNC names in bioinformatics. It’s much better to use identifiers like ESENBML IDs or whatnot.
454.
by et2o 8y ago
Best appreciated with vintage website aesthetic.
455.
Ars Technica Interview with an Ultima Online Addict (1999)(web.archive.org)
2 points by et2o 8y ago|2 comments
456.
by et2o 8y ago
And two more for plural "you" since (ihr and overloaded Sie). I like having a second person plural. I sometimes say "you guys" (although this is becoming less acceptable) or "you all" since we don't have o
457.
by et2o 8y ago
The last time I was in Germany I noticed explicitly anti-English-language grassroot campaign signs on bus stops. They are definitely worried about losing their language and perhaps the cultural identity it confers. I alternately love and ha
458.
by et2o 8y ago
I have not seen much evidence for this idea.
459.
by et2o 8y ago
While I understand running VMs are important for you and many developers, people like us who want to do this have to be a miniscule share of Apple's market. I wouldn't bet on them spending much time on it.
460.
by et2o 8y ago
What is exactly is being measured in, for example, the R script? The same code running in the same modern version of R on Ubuntu 12 and 18? Or is the R version dating to Ubuntu 12? Or is it contemporaneous for both releases? I really wish t
461.
by et2o 8y ago
To turn it around, would you even invest in some fund that offered this vehicle? They would probably lose money and you would not get the promised money back. It would be a risky investment, especially since the upside is small. Chicken and
462.
by et2o 8y ago
We don't see enough of stuff like this in Linux.
463.
by et2o 8y ago
How much does a building like this cost to purchase in Tokyo?
464.
by et2o 8y ago
16 million terabytes will be a lot of RAM for at least a couple of decades.
465.
by et2o 8y ago
https://en.wikipedia.org/wiki/Comparison_of_file_systems#Lim... For other's reference
466.
by et2o 8y ago
I had to look for a bit before I found an apple URL that wasn't behind Akamai (Linux), but: https://toolbar.netcraft.com/site_report?url=gs.apple.com#la... Just says OS is 'unknown', Apache server. So they ma
467.
by et2o 8y ago
I suppose every possible system will be imprecise to some extent. This system thus loses precision too. If you just found lat/long to x decimal places it seems like the same thing. However, I’m guessing plus codes allow you to express
468.
by et2o 8y ago
No, I don't think you have a clue. You wrote a completely wrong thing, edited it when I pointed out it was incorrect, and then 4 hours later you read up about MR on wikipedia or something and came back here and posted a partially corr
469.
by et2o 8y ago
It seems like your argument strategy is to throw out 10 different ideas. I refute them, then you throw out 10 more. Meanwhile you ignore any evidence I provide. This is not an honest conversation and no evidence is going to change your mind
470.
by et2o 8y ago
You misunderstand what mendelian randomization and instrumental variable estimation are. I'm not even sure what the methods you propose are, they're definitely not popular ways to do causal inference in medicine or epidemiology.
471.
by et2o 8y ago
LDL particle size is less studied but probably an even better indicator for CVD than LDL-C serum concentration.
472.
by et2o 8y ago
Again, this paper does not support what you're saying it does at all. You are either misreading or intentionally distorting what it says. 1) Patients had a baseline cholesterol of 106 mg/dL. So already pretty good control of lipid
473.
by et2o 8y ago
We feed the animals regular chow mixed with a percentage of pure cholesterol (0.5% by mass, if I recall, but I might be wrong). I do not mean a high saturated fat diet. This is not the introduction of complex "diet" variables as i
474.
by et2o 8y ago
To give an analogy, I feel a bit like a global warming scientist (I don't actually know anything about global warming-I just understand it's a scientific consensus with a really vocal but marginal minority). It's not just me,
475.
by et2o 8y ago
This is a really good question. I'll list a few in no particular order: From my perspective, cardiology for a while was misunderstanding the contribution made to CVD from exogenous cholesterol (what you eat) vs. endogenous cholesterol
476.
by et2o 8y ago
See above :-) I hope he/she replies to me!
477.
by et2o 8y ago
There are literally hundreds to thousands of papers where they have done exactly this: Feed animals a high-cholesterol diet and compare the results to control animals fed a normal diet. Usually they will also compare different drugs in sepa
478.
by et2o 8y ago
Could be a number of reasons: 1) Bad stuff sneaks in everywhere if you get lucky with two reviewers and an editor asleep at the wheel. Even good journals. Not usually this bad, though. 2) This isn't a particularly good journal and isn&
479.
by et2o 8y ago
Cardiovascular geneticist/statistician and physician-in-training here: This is a completely bogus and scientifically illiterate review. This small group of people in Sweden keep publishing crap like this and it's frankly kind of a
480.
by et2o 8y ago
Every positive number is a sum of infinite palindromes since they include 0 as a palindrome. Try entering 101.

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