entee

52 ms·

421.
by entee 10y ago
very cool, didn't know about this, thanks!
422.
by entee 10y ago
Very much agreed, but then you're stuck with ensuring all the pieces of DNA are faithfully transmitted through the next replication. Essentially you're proposing having tons of 1kbp chromosomes, so you're shifting the problem
423.
by entee 10y ago
You could certainly do it in an E. coli bacteria tomorrow. You'd need on the low end 128 or 256 bits of coding capacity, which you should be able to get out of a few thousand base pairs according to their scheme. Not super easy, but I&
424.
by entee 10y ago
Lots of thoughts on this. It's a really interesting area, and the paper doesn't gloss over the challenges. Important caveat right at the top though: "Progress in DNA storage has been rapid: in 1999, the state- of-the-art in D
425.
by entee 10y ago
That assumes the interview accurately measures something useful. The more I read about this area the more I think a 1-2h pre-interview practical coding assignment, then a 1 on 1 discussion during the interview is better. You then get to und
426.
by entee 10y ago
I think the point is if someone is under-represented and they merely do "OK" on the whiteboard, other latent biases might downgrade the candidate in the final analysis. I do think it's relevant to ask people to code in some f
427.
by entee 10y ago
Respectfully, I think you're missing the complications outlined in the rest of the thread. The difficulty in the biosciences and even in chemistry and some physics is that they can't really be formalized in the way that is necessa
428.
by entee 10y ago
Didn't know anything about this, really interesting! One question: when you need to know exact angle of something, say a steering wheel, if you used a grey code you'd need a really fine grained code with a huge set of numbers if y
429.
by entee 10y ago
Sounds like they would need to know how to grow massive amounts of these cells in culture for this to be viable. As others have noted here, only about 20% of the cells get the desired fix and many cells die in the process of getting the fix
430.
by entee 10y ago
Ha! I'm not sure who you're trying to convince, I keep saying I agree with you! I'm merely phrasing things a little differently. A fully free market with no regulation or intervention, as you point out, is frequently impossib
431.
by entee 10y ago
I'm with you, I think it's not going to work, but these are the kinds of arguments people make. In some ways it's a question of whose freedom are you defending? The person who put the cable in ground or the person that cable
432.
by entee 10y ago
I'm quite opposed to the guy's ideas from what I've read so far, but here's one perspective: http://www.nytimes.com/2010/03/21/opinion/21Benkler.html Some of the ways to look at it is
433.
by entee 10y ago
I'll agree with that, EU approval should prompt accelerated review. That said, thalidomide was far less bad in the US because the FDA was a little more conservative. Still, I'd be willing to say EU approval should drop the cost in
434.
by entee 10y ago
Looking at this point and one of the ones below, I think there's a bit of a misunderstanding as to why drugs are expensive and why they take so long to get to market. The hypothesis Balaji and others here suggest is that the FDA requir
435.
by entee 10y ago
Those who want the healthcare system to "work more like a market" would do well to understand this article. Healthcare is different, you don't get to price shop when you're passed out due to a car accident. Even when you
436.
by entee 10y ago
I had the same question. Toward the end, the article mentions that the military was starved for recruits and the standards relaxed a little. Maybe eventually she passed at a minimal bar and they needed bodies so she made it through. I think
437.
by entee 10y ago
Maybe so, but how many of them stay that way? How many of them are startups? How many become less successful because of it? My guess is that this is especially dangerous for startups. Think about it, you're a founder and you've be
438.
by entee 10y ago
I think the major thing this post fails to emphasize is how the CEO and other executives/managers interact. I would specifically ask: 1.) Tell me about a situation where you disagreed with your team, but trusted them and was convinced.
439.
by entee 10y ago
Is that true? It's certainly true that under many of these alternative tax structures, we can't fund what we do right now. If instead there was a list that said, "Here is the amount of money that went to each of the major fed
440.
by entee 10y ago
CAR-T-cell therapy is very promising but the salient quote here is this: "You need a good target, and that's probably the biggest obstacle to this kind of therapy," Cohen said. "We found a good target in leukemias and l
441.
by entee 10y ago
Agreed. I do jealously look at my Apple watch friends for things like locking/unlocking the laptop by proximity, no chance Garmin or FitBit gets that kind of functionality. And re. fitness, if you don't go out and use GPS for more
442.
by entee 10y ago
The elephant in the article is that he mentions Garmin, as a major player, then nearly completely ignores it. The industry isn't an Apple Watch industry, it's Apple/Samsung accessory on one side, and true fitness watch on the
443.
by entee 10y ago
I signed, I'm a fan. If in spite of all this, it or something like it does get created, I think a complimentary strategy would be to overwhelm the database and make it useless. For example, if there was a public registry, everyone shou
444.
by entee 10y ago
Logic is the wrong way to look at it, cells have no logic. They have an impossible array of equilibria, random interactions, chaotic mixing, and things we don't understand at all, along with others we may not even know exist. People li
445.
by entee 10y ago
Also that process has been around for at least 10 years: https://www.ncbi.nlm.nih.gov/pubmed/14580573 I met the guy (Charlie Nakamura) who developed the process. It took a hell of a long time to get everything working
446.
by entee 10y ago
@doctorpangloss's comment is 100% right. I'd add the small problem that behavior in small reactor != behavior in large reactor. Reactor scale-up is somewhat unpredictable and often ends in tears.
447.
by entee 10y ago
Small edit: I should have made clearer what I meant by metabolic rate. Metabolic rate in terms of heat produced per day increases as a function of mass, so humans have a higher metabolic rate by a good bit than mice. See Kleiber's law:
448.
by entee 10y ago
A few problems with the rather sensationalist headline: 1.) As others have said, mice are not people. Mouse metabolism is quite a bit faster than humans, so let's not get too hasty about conclusions. It might be real, but this is sugge
449.
by entee 10y ago
Was that the case in previous elections? I.e. in 2012?
450.
by entee 10y ago
Gerrymandering is probably the single most important issue in our democracy. It makes the House unrepresentative: democrats routinely win a higher percentage of the total vote cast for the House than their representation by number of seats

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